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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MMP3
Full Name:
Stromelysin-1
Alias:
EC 3.4.24.17; Matrix metalloproteinase-3; MMP-3; SL-1; STMY; STMY1; STR1; Transin-1
Type:
Protease
Mass (Da):
53977
Number AA:
477
UniProt ID:
P08254
International Prot ID:
IPI00027782
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0043231
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030574
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
A
A
R
G
E
D
T
S
M
N
L
V
Q
K
Y
Site 2
Y37
S
M
N
L
V
Q
K
Y
L
E
N
Y
Y
D
L
Site 3
Y41
V
Q
K
Y
L
E
N
Y
Y
D
L
K
K
D
V
Site 4
Y42
Q
K
Y
L
E
N
Y
Y
D
L
K
K
D
V
K
Site 5
S57
Q
F
V
R
R
K
D
S
G
P
V
V
K
K
I
Site 6
S81
E
V
T
G
K
L
D
S
D
T
L
E
V
M
R
Site 7
T83
T
G
K
L
D
S
D
T
L
E
V
M
R
K
P
Site 8
T102
P
D
V
G
H
F
R
T
F
P
G
I
P
K
W
Site 9
T112
G
I
P
K
W
R
K
T
H
L
T
Y
R
I
V
Site 10
Y116
W
R
K
T
H
L
T
Y
R
I
V
N
Y
T
P
Site 11
Y121
L
T
Y
R
I
V
N
Y
T
P
D
L
P
K
D
Site 12
T122
T
Y
R
I
V
N
Y
T
P
D
L
P
K
D
A
Site 13
S132
L
P
K
D
A
V
D
S
A
V
E
K
A
L
K
Site 14
T148
W
E
E
V
T
P
L
T
F
S
R
L
Y
E
G
Site 15
Y153
P
L
T
F
S
R
L
Y
E
G
E
A
D
I
M
Site 16
Y172
V
R
E
H
G
D
F
Y
P
F
D
G
P
G
N
Site 17
Y237
A
N
T
E
A
L
M
Y
P
L
Y
H
S
L
T
Site 18
T244
Y
P
L
Y
H
S
L
T
D
L
T
R
F
R
L
Site 19
T247
Y
H
S
L
T
D
L
T
R
F
R
L
S
Q
D
Site 20
S252
D
L
T
R
F
R
L
S
Q
D
D
I
N
G
I
Site 21
S261
D
D
I
N
G
I
Q
S
L
Y
G
P
P
P
D
Site 22
Y263
I
N
G
I
Q
S
L
Y
G
P
P
P
D
S
P
Site 23
S269
L
Y
G
P
P
P
D
S
P
E
T
P
L
V
P
Site 24
T272
P
P
P
D
S
P
E
T
P
L
V
P
T
E
P
Site 25
T286
P
V
P
P
E
P
G
T
P
A
N
C
D
P
A
Site 26
S318
D
R
H
F
W
R
K
S
L
R
K
L
E
P
E
Site 27
S331
P
E
L
H
L
I
S
S
F
W
P
S
L
P
S
Site 28
S338
S
F
W
P
S
L
P
S
G
V
D
A
A
Y
E
Site 29
Y344
P
S
G
V
D
A
A
Y
E
V
T
S
K
D
L
Site 30
Y372
G
N
E
V
R
A
G
Y
P
R
G
I
H
T
L
Site 31
T378
G
Y
P
R
G
I
H
T
L
G
F
P
P
T
V
Site 32
T384
H
T
L
G
F
P
P
T
V
R
K
I
D
A
A
Site 33
S393
R
K
I
D
A
A
I
S
D
K
E
K
N
K
T
Site 34
T400
S
D
K
E
K
N
K
T
Y
F
F
V
E
D
K
Site 35
Y401
D
K
E
K
N
K
T
Y
F
F
V
E
D
K
Y
Site 36
Y408
Y
F
F
V
E
D
K
Y
W
R
F
D
E
K
R
Site 37
S417
R
F
D
E
K
R
N
S
M
E
P
G
F
P
K
Site 38
S435
E
D
F
P
G
I
D
S
K
I
D
A
V
F
E
Site 39
Y448
F
E
E
F
G
F
F
Y
F
F
T
G
S
S
Q
Site 40
S454
F
Y
F
F
T
G
S
S
Q
L
E
F
D
P
N
Site 41
T468
N
A
K
K
V
T
H
T
L
K
S
N
S
W
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation