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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFIC
Full Name:
Nuclear factor 1 C-type
Alias:
CCAAT-binding transcription factor; CCAAT-box binding transcription factor; CCAAT-box-binding transcription factor; CTF; CTF5; NF1-C; NFI; NF-I; NF-I/C; NFI-C; Nuclear factor 1/C; Nuclear factor I/C; TGGCA-binding protein
Type:
Mass (Da):
55675
Number AA:
508
UniProt ID:
P08651
International Prot ID:
IPI00029795
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0000122
GO:0045944
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
Y
S
S
P
L
C
L
T
Q
Site 2
S4
_
_
_
_
M
Y
S
S
P
L
C
L
T
Q
D
Site 3
T9
Y
S
S
P
L
C
L
T
Q
D
E
F
H
P
F
Site 4
Y41
L
Q
A
R
K
R
K
Y
F
K
K
H
E
K
R
Site 5
S50
K
K
H
E
K
R
M
S
K
D
E
E
R
A
V
Site 6
S95
C
R
E
D
F
V
L
S
I
T
G
K
K
A
P
Site 7
S107
K
A
P
G
C
V
L
S
N
P
D
Q
K
G
K
Site 8
S145
F
K
G
I
P
L
E
S
T
D
G
E
R
L
V
Site 9
Y182
E
L
D
L
Y
L
A
Y
F
V
R
E
R
D
A
Site 10
S192
R
E
R
D
A
E
Q
S
G
S
P
R
T
G
M
Site 11
S194
R
D
A
E
Q
S
G
S
P
R
T
G
M
G
S
Site 12
T197
E
Q
S
G
S
P
R
T
G
M
G
S
D
Q
E
Site 13
S201
S
P
R
T
G
M
G
S
D
Q
E
D
S
K
P
Site 14
S206
M
G
S
D
Q
E
D
S
K
P
I
T
L
D
T
Site 15
T210
Q
E
D
S
K
P
I
T
L
D
T
T
D
F
Q
Site 16
T213
S
K
P
I
T
L
D
T
T
D
F
Q
E
S
F
Site 17
T214
K
P
I
T
L
D
T
T
D
F
Q
E
S
F
V
Site 18
S219
D
T
T
D
F
Q
E
S
F
V
T
S
G
V
F
Site 19
T237
E
L
I
Q
V
S
R
T
P
V
V
T
G
T
G
Site 20
T241
V
S
R
T
P
V
V
T
G
T
G
P
N
F
S
Site 21
T243
R
T
P
V
V
T
G
T
G
P
N
F
S
L
G
Site 22
S248
T
G
T
G
P
N
F
S
L
G
E
L
Q
G
H
Site 23
S264
A
Y
D
L
N
P
A
S
T
G
L
R
R
T
L
Site 24
T270
A
S
T
G
L
R
R
T
L
P
S
T
S
S
S
Site 25
S273
G
L
R
R
T
L
P
S
T
S
S
S
G
S
K
Site 26
T274
L
R
R
T
L
P
S
T
S
S
S
G
S
K
R
Site 27
S275
R
R
T
L
P
S
T
S
S
S
G
S
K
R
H
Site 28
S276
R
T
L
P
S
T
S
S
S
G
S
K
R
H
K
Site 29
S277
T
L
P
S
T
S
S
S
G
S
K
R
H
K
S
Site 30
S279
P
S
T
S
S
S
G
S
K
R
H
K
S
G
S
Site 31
S284
S
G
S
K
R
H
K
S
G
S
M
E
E
D
V
Site 32
S286
S
K
R
H
K
S
G
S
M
E
E
D
V
D
T
Site 33
T293
S
M
E
E
D
V
D
T
S
P
G
G
D
Y
Y
Site 34
S294
M
E
E
D
V
D
T
S
P
G
G
D
Y
Y
T
Site 35
Y299
D
T
S
P
G
G
D
Y
Y
T
S
P
S
S
P
Site 36
Y300
T
S
P
G
G
D
Y
Y
T
S
P
S
S
P
T
Site 37
T301
S
P
G
G
D
Y
Y
T
S
P
S
S
P
T
S
Site 38
S302
P
G
G
D
Y
Y
T
S
P
S
S
P
T
S
S
Site 39
S304
G
D
Y
Y
T
S
P
S
S
P
T
S
S
S
R
Site 40
S305
D
Y
Y
T
S
P
S
S
P
T
S
S
S
R
N
Site 41
S308
T
S
P
S
S
P
T
S
S
S
R
N
W
T
E
Site 42
S309
S
P
S
S
P
T
S
S
S
R
N
W
T
E
D
Site 43
S310
P
S
S
P
T
S
S
S
R
N
W
T
E
D
M
Site 44
T314
T
S
S
S
R
N
W
T
E
D
M
E
G
G
I
Site 45
S322
E
D
M
E
G
G
I
S
S
P
V
K
K
T
E
Site 46
S323
D
M
E
G
G
I
S
S
P
V
K
K
T
E
M
Site 47
T328
I
S
S
P
V
K
K
T
E
M
D
K
S
P
F
Site 48
S333
K
K
T
E
M
D
K
S
P
F
N
S
P
S
P
Site 49
S337
M
D
K
S
P
F
N
S
P
S
P
Q
D
S
P
Site 50
S339
K
S
P
F
N
S
P
S
P
Q
D
S
P
R
L
Site 51
S343
N
S
P
S
P
Q
D
S
P
R
L
S
S
F
T
Site 52
S347
P
Q
D
S
P
R
L
S
S
F
T
Q
H
H
R
Site 53
S348
Q
D
S
P
R
L
S
S
F
T
Q
H
H
R
P
Site 54
T350
S
P
R
L
S
S
F
T
Q
H
H
R
P
V
I
Site 55
S366
V
H
S
G
I
A
R
S
P
H
P
S
S
A
L
Site 56
S370
I
A
R
S
P
H
P
S
S
A
L
H
F
P
T
Site 57
S371
A
R
S
P
H
P
S
S
A
L
H
F
P
T
T
Site 58
T377
S
S
A
L
H
F
P
T
T
S
I
L
P
Q
T
Site 59
T384
T
T
S
I
L
P
Q
T
A
S
T
Y
F
P
H
Site 60
S386
S
I
L
P
Q
T
A
S
T
Y
F
P
H
T
A
Site 61
Y388
L
P
Q
T
A
S
T
Y
F
P
H
T
A
I
R
Site 62
T392
A
S
T
Y
F
P
H
T
A
I
R
Y
P
P
H
Site 63
Y396
F
P
H
T
A
I
R
Y
P
P
H
L
N
P
Q
Site 64
S418
S
L
A
C
D
P
A
S
Q
Q
P
G
P
L
N
Site 65
S427
Q
P
G
P
L
N
G
S
G
Q
L
K
M
P
S
Site 66
S434
S
G
Q
L
K
M
P
S
H
C
L
S
A
Q
M
Site 67
S438
K
M
P
S
H
C
L
S
A
Q
M
L
A
P
P
Site 68
T462
P
P
A
T
K
P
A
T
T
S
E
G
G
A
T
Site 69
T469
T
T
S
E
G
G
A
T
S
P
T
S
P
S
Y
Site 70
S470
T
S
E
G
G
A
T
S
P
T
S
P
S
Y
S
Site 71
T472
E
G
G
A
T
S
P
T
S
P
S
Y
S
P
P
Site 72
S473
G
G
A
T
S
P
T
S
P
S
Y
S
P
P
D
Site 73
S475
A
T
S
P
T
S
P
S
Y
S
P
P
D
T
S
Site 74
Y476
T
S
P
T
S
P
S
Y
S
P
P
D
T
S
P
Site 75
S477
S
P
T
S
P
S
Y
S
P
P
D
T
S
P
A
Site 76
T481
P
S
Y
S
P
P
D
T
S
P
A
N
R
S
F
Site 77
S482
S
Y
S
P
P
D
T
S
P
A
N
R
S
F
V
Site 78
S487
D
T
S
P
A
N
R
S
F
V
G
L
G
P
R
Site 79
Y500
P
R
D
P
A
G
I
Y
Q
A
Q
S
W
Y
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation