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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP3A4
Full Name:
Cytochrome P450 3A4
Alias:
CP33; CP34; CP3A4; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450, 3, A, 4; Cytochrome P450, family 3, subfamily A, polypeptide 4; HLP; MGC126680; NF-25; Nifedipine oxidase; P450C3; P450PCN1; P450-PCN1; Quinine 3-monooxygenase; Taurochenodeoxycholate 6-alpha-hydroxylase
Type:
EC 1.14.13.97; Xenobiotic Metabolism - drug metabolism - other enzymes; Cell surface; Lipid Metabolism - linoleic acid; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol; EC 1.14.13.67; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Mass (Da):
57343
Number AA:
503
UniProt ID:
P08684
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0047638
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0009822
GO:0042737
GO:0016098
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
L
Y
L
Y
G
T
H
S
H
G
L
F
K
K
L
Site 2
Y75
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
Site 3
T92
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
Site 4
Y99
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
Site 5
S100
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
Site 6
T103
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
Site 7
S119
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
Site 8
S131
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
Site 9
S134
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
Site 10
T136
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
Site 11
T138
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
Site 12
S139
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
Site 13
T166
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
Site 14
S195
S
F
G
V
N
I
D
S
L
N
N
P
Q
D
P
Site 15
S252
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
Site 16
S259
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
K
Site 17
T264
K
E
S
R
L
E
D
T
Q
K
H
R
V
D
F
Site 18
S278
F
L
Q
L
M
I
D
S
Q
N
S
K
E
T
E
Site 19
S281
L
M
I
D
S
Q
N
S
K
E
T
E
S
H
K
Site 20
T284
D
S
Q
N
S
K
E
T
E
S
H
K
A
L
S
Site 21
S286
Q
N
S
K
E
T
E
S
H
K
A
L
S
D
L
Site 22
S291
T
E
S
H
K
A
L
S
D
L
E
L
V
A
Q
Site 23
T346
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
Site 24
Y347
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Site 25
T349
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
Site 26
S398
G
V
V
V
M
I
P
S
Y
A
L
H
R
D
P
Site 27
Y407
A
L
H
R
D
P
K
Y
W
T
E
P
E
K
F
Site 28
S420
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
Site 29
Y430
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
Site 30
Y432
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
Site 31
T433
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
Site 32
S464
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Site 33
T471
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
Site 34
S478
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
Site 35
S495
P
V
V
L
K
V
E
S
R
D
G
T
V
S
G
Site 36
T499
K
V
E
S
R
D
G
T
V
S
G
A
_
_
_
Site 37
S501
E
S
R
D
G
T
V
S
G
A
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation