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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP21A2
Full Name:
Steroid 21-hydroxylase
Alias:
21-OHase;Cytochrome P-450c21;Cytochrome P450 21;Cytochrome P450 XXI;Cytochrome P450-C21;Cytochrome P450-C21B
Type:
Mass (Da):
55887
Number AA:
494
UniProt ID:
P08686
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y59
T
Q
K
F
G
P
I
Y
R
L
H
L
G
L
Q
Site 2
S73
Q
D
V
V
V
L
N
S
K
R
T
I
E
E
A
Site 3
T76
V
V
L
N
S
K
R
T
I
E
E
A
M
V
K
Site 4
T96
A
G
R
P
E
P
L
T
Y
K
L
V
S
K
N
Site 5
Y97
G
R
P
E
P
L
T
Y
K
L
V
S
K
N
Y
Site 6
S101
P
L
T
Y
K
L
V
S
K
N
Y
P
D
L
S
Site 7
Y104
Y
K
L
V
S
K
N
Y
P
D
L
S
L
G
D
Site 8
S108
S
K
N
Y
P
D
L
S
L
G
D
Y
S
L
L
Site 9
Y112
P
D
L
S
L
G
D
Y
S
L
L
W
K
A
H
Site 10
S113
D
L
S
L
G
D
Y
S
L
L
W
K
A
H
K
Site 11
T123
W
K
A
H
K
K
L
T
R
S
A
L
L
L
G
Site 12
S125
A
H
K
K
L
T
R
S
A
L
L
L
G
I
R
Site 13
T156
R
M
R
A
Q
P
G
T
P
V
A
I
E
E
E
Site 14
Y190
D
D
N
L
M
P
A
Y
Y
K
C
I
Q
E
V
Site 15
Y191
D
N
L
M
P
A
Y
Y
K
C
I
Q
E
V
L
Site 16
S247
Q
L
R
Q
H
K
E
S
L
V
A
G
Q
W
R
Site 17
S268
L
Q
G
V
A
Q
P
S
M
E
E
G
S
G
Q
Site 18
S330
H
E
L
G
P
G
A
S
S
S
R
V
P
Y
K
Site 19
S331
E
L
G
P
G
A
S
S
S
R
V
P
Y
K
D
Site 20
S332
L
G
P
G
A
S
S
S
R
V
P
Y
K
D
R
Site 21
Y336
A
S
S
S
R
V
P
Y
K
D
R
A
R
L
P
Site 22
T367
P
L
A
L
P
H
R
T
T
R
P
S
S
I
S
Site 23
T368
L
A
L
P
H
R
T
T
R
P
S
S
I
S
G
Site 24
S371
P
H
R
T
T
R
P
S
S
I
S
G
Y
D
I
Site 25
S372
H
R
T
T
R
P
S
S
I
S
G
Y
D
I
P
Site 26
S374
T
T
R
P
S
S
I
S
G
Y
D
I
P
E
G
Site 27
Y376
R
P
S
S
I
S
G
Y
D
I
P
E
G
T
V
Site 28
T396
Q
G
A
H
L
D
E
T
V
W
E
R
P
H
E
Site 29
S460
P
S
G
D
A
L
P
S
L
Q
P
L
P
H
C
Site 30
S489
P
R
G
M
G
A
H
S
P
G
Q
N
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation