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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT19
Full Name:
Keratin, type I cytoskeletal 19
Alias:
40-kDa keratin intermediate filament; CK 19; CK19; Cytokeratin 19; Cytokeratin-19; K1C19; K1CS; Keratin; Keratin 19; Keratin, type I, 40-kd; Keratin-19; KRT1-19; MGC15366; Type I cytoskeletal 19
Type:
Cytoskeletal protein
Mass (Da):
44092
Number AA:
400
UniProt ID:
P08727
International Prot ID:
IPI00479145
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043034
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005200
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0043627
GO:0045214
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
T
S
Y
S
Y
R
Q
S
S
A
T
S
S
F
G
Site 2
S10
S
Y
S
Y
R
Q
S
S
A
T
S
S
F
G
G
Site 3
T12
S
Y
R
Q
S
S
A
T
S
S
F
G
G
L
G
Site 4
S13
Y
R
Q
S
S
A
T
S
S
F
G
G
L
G
G
Site 5
S14
R
Q
S
S
A
T
S
S
F
G
G
L
G
G
G
Site 6
S35
G
V
A
F
R
A
P
S
I
H
G
G
S
G
G
Site 7
S40
A
P
S
I
H
G
G
S
G
G
R
G
V
S
V
Site 8
S46
G
S
G
G
R
G
V
S
V
S
S
A
R
F
V
Site 9
S48
G
G
R
G
V
S
V
S
S
A
R
F
V
S
S
Site 10
S49
G
R
G
V
S
V
S
S
A
R
F
V
S
S
S
Site 11
S54
V
S
S
A
R
F
V
S
S
S
S
S
G
G
Y
Site 12
S55
S
S
A
R
F
V
S
S
S
S
S
G
G
Y
G
Site 13
S56
S
A
R
F
V
S
S
S
S
S
G
G
Y
G
G
Site 14
S57
A
R
F
V
S
S
S
S
S
G
G
Y
G
G
G
Site 15
S58
R
F
V
S
S
S
S
S
G
G
Y
G
G
G
Y
Site 16
Y61
S
S
S
S
S
G
G
Y
G
G
G
Y
G
G
V
Site 17
Y65
S
G
G
Y
G
G
G
Y
G
G
V
L
T
A
S
Site 18
S72
Y
G
G
V
L
T
A
S
D
G
L
L
A
G
N
Site 19
S93
N
L
N
D
R
L
A
S
Y
L
D
K
V
R
A
Site 20
Y94
L
N
D
R
L
A
S
Y
L
D
K
V
R
A
L
Site 21
Y116
E
V
K
I
R
D
W
Y
Q
K
Q
G
P
G
P
Site 22
S124
Q
K
Q
G
P
G
P
S
R
D
Y
S
H
Y
Y
Site 23
Y127
G
P
G
P
S
R
D
Y
S
H
Y
Y
T
T
I
Site 24
S128
P
G
P
S
R
D
Y
S
H
Y
Y
T
T
I
Q
Site 25
Y130
P
S
R
D
Y
S
H
Y
Y
T
T
I
Q
D
L
Site 26
Y131
S
R
D
Y
S
H
Y
Y
T
T
I
Q
D
L
R
Site 27
T132
R
D
Y
S
H
Y
Y
T
T
I
Q
D
L
R
D
Site 28
T145
R
D
K
I
L
G
A
T
I
E
N
S
R
I
V
Site 29
T171
D
F
R
T
K
F
E
T
E
Q
A
L
R
M
S
Site 30
S178
T
E
Q
A
L
R
M
S
V
E
A
D
I
N
G
Site 31
T194
R
R
V
L
D
E
L
T
L
A
R
T
D
L
E
Site 32
Y213
G
L
K
E
E
L
A
Y
L
K
K
N
H
E
E
Site 33
S223
K
N
H
E
E
E
I
S
T
L
R
G
Q
V
G
Site 34
T224
N
H
E
E
E
I
S
T
L
R
G
Q
V
G
G
Site 35
S234
G
Q
V
G
G
Q
V
S
V
E
V
D
S
A
P
Site 36
T243
E
V
D
S
A
P
G
T
D
L
A
K
I
L
S
Site 37
S250
T
D
L
A
K
I
L
S
D
M
R
S
Q
Y
E
Site 38
S254
K
I
L
S
D
M
R
S
Q
Y
E
V
M
A
E
Site 39
Y256
L
S
D
M
R
S
Q
Y
E
V
M
A
E
Q
N
Site 40
T272
K
D
A
E
A
W
F
T
S
R
T
E
E
L
N
Site 41
S273
D
A
E
A
W
F
T
S
R
T
E
E
L
N
R
Site 42
T275
E
A
W
F
T
S
R
T
E
E
L
N
R
E
V
Site 43
S294
E
Q
L
Q
M
S
R
S
E
V
T
D
L
R
R
Site 44
T302
E
V
T
D
L
R
R
T
L
Q
G
L
E
I
E
Site 45
S312
G
L
E
I
E
L
Q
S
Q
L
S
M
K
A
A
Site 46
S315
I
E
L
Q
S
Q
L
S
M
K
A
A
L
E
D
Site 47
T323
M
K
A
A
L
E
D
T
L
A
E
T
E
A
R
Site 48
T327
L
E
D
T
L
A
E
T
E
A
R
F
G
A
Q
Site 49
S356
L
G
D
V
R
A
D
S
E
R
Q
N
Q
E
Y
Site 50
Y363
S
E
R
Q
N
Q
E
Y
Q
R
L
M
D
I
K
Site 51
S371
Q
R
L
M
D
I
K
S
R
L
E
Q
E
I
A
Site 52
Y380
L
E
Q
E
I
A
T
Y
R
S
L
L
E
G
Q
Site 53
Y391
L
E
G
Q
E
D
H
Y
N
N
L
S
A
S
K
Site 54
S395
E
D
H
Y
N
N
L
S
A
S
K
V
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation