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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHRM5
Full Name:
Muscarinic acetylcholine receptor M5
Alias:
Type:
Mass (Da):
60074
Number AA:
532
UniProt ID:
P08912
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
D
S
Y
H
N
A
T
T
V
N
G
T
P
V
N
Site 2
T15
N
A
T
T
V
N
G
T
P
V
N
H
Q
P
L
Site 3
S59
M
I
S
F
K
V
N
S
Q
L
K
T
V
N
N
Site 4
T63
K
V
N
S
Q
L
K
T
V
N
N
Y
Y
L
L
Site 5
S131
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
Site 6
T133
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
Site 7
T137
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
P
Site 8
T143
L
T
Y
R
A
K
R
T
P
K
R
A
G
I
M
Site 9
Y217
T
I
L
Y
C
R
I
Y
R
E
T
E
K
R
T
Site 10
T220
Y
C
R
I
Y
R
E
T
E
K
R
T
K
D
L
Site 11
S235
A
D
L
Q
G
S
D
S
V
T
K
A
E
K
R
Site 12
T237
L
Q
G
S
D
S
V
T
K
A
E
K
R
K
P
Site 13
S252
A
H
R
A
L
F
R
S
C
L
R
C
P
R
P
Site 14
T260
C
L
R
C
P
R
P
T
L
A
Q
R
E
R
N
Site 15
S270
Q
R
E
R
N
Q
A
S
W
S
S
S
R
R
S
Site 16
S272
E
R
N
Q
A
S
W
S
S
S
R
R
S
T
S
Site 17
S273
R
N
Q
A
S
W
S
S
S
R
R
S
T
S
T
Site 18
S274
N
Q
A
S
W
S
S
S
R
R
S
T
S
T
T
Site 19
S277
S
W
S
S
S
R
R
S
T
S
T
T
G
K
P
Site 20
T278
W
S
S
S
R
R
S
T
S
T
T
G
K
P
S
Site 21
S279
S
S
S
R
R
S
T
S
T
T
G
K
P
S
Q
Site 22
T280
S
S
R
R
S
T
S
T
T
G
K
P
S
Q
A
Site 23
T281
S
R
R
S
T
S
T
T
G
K
P
S
Q
A
T
Site 24
S285
T
S
T
T
G
K
P
S
Q
A
T
G
P
S
A
Site 25
T301
W
A
K
A
E
Q
L
T
T
C
S
S
Y
P
S
Site 26
T302
A
K
A
E
Q
L
T
T
C
S
S
Y
P
S
S
Site 27
S304
A
E
Q
L
T
T
C
S
S
Y
P
S
S
E
D
Site 28
S305
E
Q
L
T
T
C
S
S
Y
P
S
S
E
D
E
Site 29
Y306
Q
L
T
T
C
S
S
Y
P
S
S
E
D
E
D
Site 30
S308
T
T
C
S
S
Y
P
S
S
E
D
E
D
K
P
Site 31
S309
T
C
S
S
Y
P
S
S
E
D
E
D
K
P
A
Site 32
S327
V
L
Q
V
V
Y
K
S
Q
G
K
E
S
P
G
Site 33
S332
Y
K
S
Q
G
K
E
S
P
G
E
E
F
S
A
Site 34
T342
E
E
F
S
A
E
E
T
E
E
T
F
V
K
A
Site 35
T345
S
A
E
E
T
E
E
T
F
V
K
A
E
T
E
Site 36
S354
V
K
A
E
T
E
K
S
D
Y
D
T
P
N
Y
Site 37
Y356
A
E
T
E
K
S
D
Y
D
T
P
N
Y
L
L
Site 38
T358
T
E
K
S
D
Y
D
T
P
N
Y
L
L
S
P
Site 39
Y361
S
D
Y
D
T
P
N
Y
L
L
S
P
A
A
A
Site 40
S364
D
T
P
N
Y
L
L
S
P
A
A
A
H
R
P
Site 41
S373
A
A
A
H
R
P
K
S
Q
K
C
V
A
Y
K
Site 42
S414
F
P
V
A
K
E
P
S
T
K
G
L
N
P
N
Site 43
S423
K
G
L
N
P
N
P
S
H
Q
M
T
K
R
K
Site 44
T427
P
N
P
S
H
Q
M
T
K
R
K
R
V
V
L
Site 45
Y485
H
L
G
Y
W
L
C
Y
V
N
S
T
V
N
P
Site 46
Y524
K
K
V
E
E
K
L
Y
W
Q
G
N
S
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation