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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DBH
Full Name:
Dopamine beta-hydroxylase
Alias:
Dopamine beta-monooxygenase
Type:
Mass (Da):
69065
Number AA:
617
UniProt ID:
P09172
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
A
L
S
R
W
A
S
L
P
G
P
S
M
R
Site 2
S45
Q
G
S
A
P
R
E
S
P
L
P
Y
H
I
P
Site 3
Y49
P
R
E
S
P
L
P
Y
H
I
P
L
D
P
E
Site 4
S58
I
P
L
D
P
E
G
S
L
E
L
S
W
N
V
Site 5
S62
P
E
G
S
L
E
L
S
W
N
V
S
Y
T
Q
Site 6
S66
L
E
L
S
W
N
V
S
Y
T
Q
E
A
I
H
Site 7
S90
A
G
V
L
F
G
M
S
D
R
G
E
L
E
N
Site 8
Y111
W
T
D
G
D
T
A
Y
F
A
D
A
W
S
D
Site 9
Y131
H
L
D
P
Q
Q
D
Y
Q
L
L
Q
V
Q
R
Site 10
Y159
G
T
C
D
P
K
D
Y
L
I
E
D
G
T
V
Site 11
S179
I
L
E
E
P
F
R
S
L
E
A
I
N
G
S
Site 12
S209
I
P
E
P
E
L
P
S
D
A
C
T
M
E
V
Site 13
T213
E
L
P
S
D
A
C
T
M
E
V
Q
A
P
N
Site 14
Y230
I
P
S
Q
E
T
T
Y
W
C
Y
I
K
E
L
Site 15
Y249
S
R
H
H
I
I
K
Y
E
P
I
V
T
K
G
Site 16
S275
Q
C
A
P
E
M
D
S
V
P
H
F
S
G
P
Site 17
S285
H
F
S
G
P
C
D
S
K
M
K
P
D
R
L
Site 18
Y294
M
K
P
D
R
L
N
Y
C
R
H
V
L
A
A
Site 19
Y310
A
L
G
A
K
A
F
Y
Y
P
E
E
A
G
L
Site 20
S324
L
A
F
G
G
P
G
S
S
R
Y
L
R
L
E
Site 21
S325
A
F
G
G
P
G
S
S
R
Y
L
R
L
E
V
Site 22
Y327
G
G
P
G
S
S
R
Y
L
R
L
E
V
H
Y
Site 23
Y334
Y
L
R
L
E
V
H
Y
H
N
P
L
V
I
E
Site 24
S346
V
I
E
G
R
N
D
S
S
G
I
R
L
Y
Y
Site 25
S347
I
E
G
R
N
D
S
S
G
I
R
L
Y
Y
T
Site 26
Y352
D
S
S
G
I
R
L
Y
Y
T
A
K
L
R
R
Site 27
Y353
S
S
G
I
R
L
Y
Y
T
A
K
L
R
R
F
Site 28
T354
S
G
I
R
L
Y
Y
T
A
K
L
R
R
F
N
Site 29
T395
G
Y
C
T
D
K
C
T
Q
L
A
L
P
P
S
Site 30
T413
I
F
A
S
Q
L
H
T
H
L
T
G
R
K
V
Site 31
T416
S
Q
L
H
T
H
L
T
G
R
K
V
V
T
V
Site 32
T422
L
T
G
R
K
V
V
T
V
L
V
R
D
G
R
Site 33
Y440
I
V
N
Q
D
N
H
Y
S
P
H
F
Q
E
I
Site 34
S465
P
G
D
V
L
I
T
S
C
T
Y
N
T
E
D
Site 35
Y491
L
E
E
M
C
V
N
Y
V
H
Y
Y
P
Q
T
Site 36
Y495
C
V
N
Y
V
H
Y
Y
P
Q
T
Q
L
E
L
Site 37
Y515
D
A
G
F
L
Q
K
Y
F
H
L
I
N
R
F
Site 38
T529
F
N
N
E
D
V
C
T
C
P
Q
A
S
V
S
Site 39
S534
V
C
T
C
P
Q
A
S
V
S
Q
Q
F
T
S
Site 40
S536
T
C
P
Q
A
S
V
S
Q
Q
F
T
S
V
P
Site 41
T540
A
S
V
S
Q
Q
F
T
S
V
P
W
N
S
F
Site 42
S541
S
V
S
Q
Q
F
T
S
V
P
W
N
S
F
N
Site 43
S546
F
T
S
V
P
W
N
S
F
N
R
D
V
L
K
Site 44
S569
S
M
H
C
N
K
S
S
A
V
R
F
Q
G
E
Site 45
S587
Q
P
L
P
K
V
I
S
T
L
E
E
P
T
P
Site 46
T588
P
L
P
K
V
I
S
T
L
E
E
P
T
P
Q
Site 47
T593
I
S
T
L
E
E
P
T
P
Q
C
P
T
S
Q
Site 48
S599
P
T
P
Q
C
P
T
S
Q
G
R
S
P
A
G
Site 49
S603
C
P
T
S
Q
G
R
S
P
A
G
P
T
V
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation