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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
villin
Full Name:
Villin-1
Alias:
D2S1471; VIL; VIL1; VILI; Villin 1
Type:
Actin binding protein
Mass (Da):
92695
Number AA:
827
UniProt ID:
P09327
International Prot ID:
IPI00218852
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0051693
GO:0051014
GO:0007010
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
S
A
Q
V
K
G
S
L
N
I
T
T
P
G
Site 2
T15
V
K
G
S
L
N
I
T
T
P
G
L
Q
I
W
Site 3
T16
K
G
S
L
N
I
T
T
P
G
L
Q
I
W
R
Site 4
S39
V
P
S
S
T
F
G
S
F
F
D
G
D
C
Y
Site 5
Y46
S
F
F
D
G
D
C
Y
I
I
L
A
I
H
K
Site 6
S57
A
I
H
K
T
A
S
S
L
S
Y
D
I
H
Y
Site 7
Y60
K
T
A
S
S
L
S
Y
D
I
H
Y
W
I
G
Site 8
Y64
S
L
S
Y
D
I
H
Y
W
I
G
Q
D
S
S
Site 9
S71
Y
W
I
G
Q
D
S
S
L
D
E
Q
G
A
A
Site 10
Y81
E
Q
G
A
A
A
I
Y
T
T
Q
M
D
D
F
Site 11
S104
R
E
V
Q
G
N
E
S
E
A
F
R
G
Y
F
Site 12
Y110
E
S
E
A
F
R
G
Y
F
K
Q
G
L
V
I
Site 13
Y134
K
H
V
E
T
N
S
Y
D
V
Q
R
L
L
H
Site 14
S156
V
A
G
E
V
E
M
S
W
K
S
F
N
R
G
Site 15
S182
I
Q
W
N
G
P
E
S
T
R
M
E
R
L
R
Site 16
T192
M
E
R
L
R
G
M
T
L
A
K
E
I
R
D
Site 17
T206
D
Q
E
R
G
G
R
T
Y
V
G
V
V
D
G
Site 18
Y207
Q
E
R
G
G
R
T
Y
V
G
V
V
D
G
E
Site 19
S219
D
G
E
N
E
L
A
S
P
K
L
M
E
V
M
Site 20
Y256
L
K
A
A
L
K
L
Y
H
V
S
D
S
E
G
Site 21
S259
A
L
K
L
Y
H
V
S
D
S
E
G
N
L
V
Site 22
S261
K
L
Y
H
V
S
D
S
E
G
N
L
V
V
R
Site 23
T276
E
V
A
T
R
P
L
T
Q
D
L
L
S
H
E
Site 24
S281
P
L
T
Q
D
L
L
S
H
E
D
C
Y
I
L
Site 25
Y286
L
L
S
H
E
D
C
Y
I
L
D
Q
G
G
L
Site 26
Y296
D
Q
G
G
L
K
I
Y
V
W
K
G
K
K
A
Site 27
Y324
N
F
I
K
A
K
Q
Y
P
P
S
T
Q
V
E
Site 28
S327
K
A
K
Q
Y
P
P
S
T
Q
V
E
V
Q
N
Site 29
T328
A
K
Q
Y
P
P
S
T
Q
V
E
V
Q
N
D
Site 30
T350
Q
Q
L
F
Q
K
W
T
A
S
N
R
T
S
G
Site 31
S352
L
F
Q
K
W
T
A
S
N
R
T
S
G
L
G
Site 32
S356
W
T
A
S
N
R
T
S
G
L
G
K
T
H
T
Site 33
T361
R
T
S
G
L
G
K
T
H
T
V
G
S
V
A
Site 34
S366
G
K
T
H
T
V
G
S
V
A
K
V
E
Q
V
Site 35
S379
Q
V
K
F
D
A
T
S
M
H
V
K
P
Q
V
Site 36
S397
Q
K
M
V
D
D
G
S
G
E
V
Q
V
W
R
Site 37
Y422
S
K
W
L
G
H
F
Y
G
G
D
C
Y
L
L
Site 38
Y441
L
I
G
E
K
Q
H
Y
L
L
Y
V
W
Q
G
Site 39
Y444
E
K
Q
H
Y
L
L
Y
V
W
Q
G
S
Q
A
Site 40
S449
L
L
Y
V
W
Q
G
S
Q
A
S
Q
D
E
I
Site 41
Y461
D
E
I
T
A
S
A
Y
Q
A
V
I
L
D
Q
Site 42
Y470
A
V
I
L
D
Q
K
Y
N
G
E
P
V
Q
I
Site 43
Y499
F
K
G
R
M
V
V
Y
Q
G
G
T
S
R
T
Site 44
S514
N
N
L
E
T
G
P
S
T
R
L
F
Q
V
Q
Site 45
Y555
L
K
T
Q
S
C
C
Y
L
W
C
G
K
G
C
Site 46
T576
M
A
K
M
V
A
D
T
I
S
R
T
E
K
Q
Site 47
S578
K
M
V
A
D
T
I
S
R
T
E
K
Q
V
V
Site 48
Y604
A
L
G
G
K
A
P
Y
A
N
T
K
R
L
Q
Site 49
T618
Q
E
E
N
L
V
I
T
P
R
L
F
E
C
S
Site 50
S625
T
P
R
L
F
E
C
S
N
K
T
G
R
F
L
Site 51
T634
K
T
G
R
F
L
A
T
E
I
P
D
F
N
Q
Site 52
Y681
A
A
T
T
A
Q
E
Y
L
K
T
H
P
S
G
Site 53
T684
T
A
Q
E
Y
L
K
T
H
P
S
G
R
D
P
Site 54
S687
E
Y
L
K
T
H
P
S
G
R
D
P
E
T
P
Site 55
T693
P
S
G
R
D
P
E
T
P
I
I
V
V
K
Q
Site 56
T706
K
Q
G
H
E
P
P
T
F
T
G
W
F
L
A
Site 57
S724
F
K
W
S
N
T
K
S
Y
E
D
L
K
A
E
Site 58
Y725
K
W
S
N
T
K
S
Y
E
D
L
K
A
E
S
Site 59
S735
L
K
A
E
L
G
N
S
R
D
W
S
Q
I
T
Site 60
S739
L
G
N
S
R
D
W
S
Q
I
T
A
E
V
T
Site 61
S747
Q
I
T
A
E
V
T
S
P
K
V
D
V
F
N
Site 62
S757
V
D
V
F
N
A
N
S
N
L
S
S
G
P
L
Site 63
S761
N
A
N
S
N
L
S
S
G
P
L
P
I
F
P
Site 64
S787
L
P
E
G
V
D
P
S
R
K
E
E
H
L
S
Site 65
S794
S
R
K
E
E
H
L
S
I
E
D
F
T
Q
A
Site 66
T799
H
L
S
I
E
D
F
T
Q
A
F
G
M
T
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation