KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
QDPR
Full Name:
Dihydropteridine reductase
Alias:
6,7-dihydropteridine reductase; DHPR; Dihydropteridine reductase; EC 1.5.1.34; HDHPR; PKU2; SDR33C1; Short chain dehydrogenase/reductase family 33C, member 1
Type:
Cofactor and Vitamin Metabolism - folate biosynthesis; EC 1.5.1.34; Oxidoreductase
Mass (Da):
25790
Number AA:
244
UniProt ID:
P09417
International Prot ID:
IPI00014439
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004155
GO:0005488
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0006520
GO:0051066
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
E
A
R
R
V
L
V
Y
G
G
R
G
A
L
G
Site 2
S24
G
G
R
G
A
L
G
S
R
C
V
Q
A
F
R
Site 3
S51
E
N
E
E
A
S
A
S
I
I
V
K
M
T
D
Site 4
S59
I
I
V
K
M
T
D
S
F
T
E
Q
A
D
Q
Site 5
S99
G
G
N
A
K
S
K
S
L
F
K
N
C
D
L
Site 6
T114
M
W
K
Q
S
I
W
T
S
T
I
S
S
H
L
Site 7
S115
W
K
Q
S
I
W
T
S
T
I
S
S
H
L
A
Site 8
T116
K
Q
S
I
W
T
S
T
I
S
S
H
L
A
T
Site 9
S119
I
W
T
S
T
I
S
S
H
L
A
T
K
H
L
Site 10
T123
T
I
S
S
H
L
A
T
K
H
L
K
E
G
G
Site 11
T133
L
K
E
G
G
L
L
T
L
A
G
A
K
A
A
Site 12
S163
A
V
H
Q
L
C
Q
S
L
A
G
K
N
S
G
Site 13
S169
Q
S
L
A
G
K
N
S
G
M
P
P
G
A
A
Site 14
T184
A
I
A
V
L
P
V
T
L
D
T
P
M
N
R
Site 15
T187
V
L
P
V
T
L
D
T
P
M
N
R
K
S
M
Site 16
S193
D
T
P
M
N
R
K
S
M
P
E
A
D
F
S
Site 17
S200
S
M
P
E
A
D
F
S
S
W
T
P
L
E
F
Site 18
S201
M
P
E
A
D
F
S
S
W
T
P
L
E
F
L
Site 19
T203
E
A
D
F
S
S
W
T
P
L
E
F
L
V
E
Site 20
T217
E
T
F
H
D
W
I
T
G
K
N
R
P
S
S
Site 21
S223
I
T
G
K
N
R
P
S
S
G
S
L
I
Q
V
Site 22
S224
T
G
K
N
R
P
S
S
G
S
L
I
Q
V
V
Site 23
S226
K
N
R
P
S
S
G
S
L
I
Q
V
V
T
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation