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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HMGB1
Full Name:
High mobility group protein B1
Alias:
Amphoterin; DKFZp686A04236; High mobility group box 1; High mobility group protein 1; High-mobility group box 1; HMG1; HMG-1; HMG3; SBP-1; Sulfoglucuronyl carbohydrate binding protein; Sulfoglucuronyl carbohydrate binding protein high-mobility group (nonhistone chromosomal) protein 1
Type:
DNA repair; Nuclear receptor co-regulator
Mass (Da):
24894
Number AA:
215
UniProt ID:
P09429
International Prot ID:
IPI00419258
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000793
GO:0005730
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008301
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006268
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
K
P
R
G
K
M
S
S
Y
A
F
F
V
Q
T
Site 2
Y16
P
R
G
K
M
S
S
Y
A
F
F
V
Q
T
C
Site 3
T22
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
Site 4
S35
K
K
K
H
P
D
A
S
V
N
F
S
E
F
S
Site 5
S39
P
D
A
S
V
N
F
S
E
F
S
K
K
C
S
Site 6
S42
S
V
N
F
S
E
F
S
K
K
C
S
E
R
W
Site 7
S46
S
E
F
S
K
K
C
S
E
R
W
K
T
M
S
Site 8
T51
K
C
S
E
R
W
K
T
M
S
A
K
E
K
G
Site 9
S53
S
E
R
W
K
T
M
S
A
K
E
K
G
K
F
Site 10
Y71
A
K
A
D
K
A
R
Y
E
R
E
M
K
T
Y
Site 11
T77
R
Y
E
R
E
M
K
T
Y
I
P
P
K
G
E
Site 12
Y78
Y
E
R
E
M
K
T
Y
I
P
P
K
G
E
T
Site 13
S100
N
A
P
K
R
P
P
S
A
F
F
L
F
C
S
Site 14
S107
S
A
F
F
L
F
C
S
E
Y
R
P
K
I
K
Site 15
Y109
F
F
L
F
C
S
E
Y
R
P
K
I
K
G
E
Site 16
S121
K
G
E
H
P
G
L
S
I
G
D
V
A
K
K
Site 17
Y144
A
A
D
D
K
Q
P
Y
E
K
K
A
A
K
L
Site 18
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Site 19
Y162
Y
E
K
D
I
A
A
Y
R
A
K
G
K
P
D
Site 20
S181
G
V
V
K
A
E
K
S
K
K
K
K
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation