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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C1s
Full Name:
Complement C1s subcomponent
Alias:
C1 esterase; Complement C1s subcomponent; Complement component 1, s subcomponent; CS1B
Type:
Protease; EC 3.4.21.42
Mass (Da):
76666
Number AA:
688
UniProt ID:
P09871
International Prot ID:
IPI00017696
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006958
GO:0045087
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
V
Y
A
E
P
T
M
Y
G
E
I
L
S
P
N
Site 2
S25
T
M
Y
G
E
I
L
S
P
N
Y
P
Q
A
Y
Site 3
Y28
G
E
I
L
S
P
N
Y
P
Q
A
Y
P
S
E
Site 4
Y32
S
P
N
Y
P
Q
A
Y
P
S
E
V
E
K
S
Site 5
S34
N
Y
P
Q
A
Y
P
S
E
V
E
K
S
W
D
Site 6
S39
Y
P
S
E
V
E
K
S
W
D
I
E
V
P
E
Site 7
Y53
E
G
Y
G
I
H
L
Y
F
T
H
L
D
I
E
Site 8
S62
T
H
L
D
I
E
L
S
E
N
C
A
Y
D
S
Site 9
Y67
E
L
S
E
N
C
A
Y
D
S
V
Q
I
I
S
Site 10
S69
S
E
N
C
A
Y
D
S
V
Q
I
I
S
G
D
Site 11
T77
V
Q
I
I
S
G
D
T
E
E
G
R
L
C
G
Site 12
S87
G
R
L
C
G
Q
R
S
S
N
N
P
H
S
P
Site 13
S88
R
L
C
G
Q
R
S
S
N
N
P
H
S
P
I
Site 14
S93
R
S
S
N
N
P
H
S
P
I
V
E
E
F
Q
Site 15
S112
K
L
Q
V
I
F
K
S
D
F
S
N
E
E
R
Site 16
S115
V
I
F
K
S
D
F
S
N
E
E
R
F
T
G
Site 17
T121
F
S
N
E
E
R
F
T
G
F
A
A
Y
Y
V
Site 18
S189
A
L
I
G
E
I
A
S
P
N
Y
P
K
P
Y
Site 19
Y192
G
E
I
A
S
P
N
Y
P
K
P
Y
P
E
N
Site 20
Y196
S
P
N
Y
P
K
P
Y
P
E
N
S
R
C
E
Site 21
Y204
P
E
N
S
R
C
E
Y
Q
I
R
L
E
K
G
Site 22
T217
K
G
F
Q
V
V
V
T
L
R
R
E
D
F
D
Site 23
S230
F
D
V
E
A
A
D
S
A
G
N
C
L
D
S
Site 24
Y250
G
D
R
Q
F
G
P
Y
C
G
H
G
F
P
G
Site 25
T277
I
I
F
Q
T
D
L
T
G
Q
K
K
G
W
K
Site 26
Y287
K
K
G
W
K
L
R
Y
H
G
D
P
M
P
C
Site 27
T299
M
P
C
P
K
E
D
T
P
N
S
V
W
E
P
Site 28
S302
P
K
E
D
T
P
N
S
V
W
E
P
A
K
A
Site 29
Y311
W
E
P
A
K
A
K
Y
V
F
R
D
V
V
Q
Site 30
S336
E
G
R
V
G
A
T
S
F
Y
S
T
C
Q
S
Site 31
Y338
R
V
G
A
T
S
F
Y
S
T
C
Q
S
N
G
Site 32
S339
V
G
A
T
S
F
Y
S
T
C
Q
S
N
G
K
Site 33
T340
G
A
T
S
F
Y
S
T
C
Q
S
N
G
K
W
Site 34
S350
S
N
G
K
W
S
N
S
K
L
K
C
Q
P
V
Site 35
S364
V
D
C
G
I
P
E
S
I
E
N
G
K
V
E
Site 36
S375
G
K
V
E
D
P
E
S
T
L
F
G
S
V
I
Site 37
T376
K
V
E
D
P
E
S
T
L
F
G
S
V
I
R
Site 38
S380
P
E
S
T
L
F
G
S
V
I
R
Y
T
C
E
Site 39
Y384
L
F
G
S
V
I
R
Y
T
C
E
E
P
Y
Y
Site 40
T385
F
G
S
V
I
R
Y
T
C
E
E
P
Y
Y
Y
Site 41
Y390
R
Y
T
C
E
E
P
Y
Y
Y
M
E
N
G
G
Site 42
Y391
Y
T
C
E
E
P
Y
Y
Y
M
E
N
G
G
G
Site 43
Y392
T
C
E
E
P
Y
Y
Y
M
E
N
G
G
G
G
Site 44
Y401
E
N
G
G
G
G
E
Y
H
C
A
G
N
G
S
Site 45
S442
K
Q
R
I
I
G
G
S
D
A
D
I
K
N
F
Site 46
T484
V
E
G
N
R
E
P
T
M
Y
V
G
S
T
S
Site 47
Y486
G
N
R
E
P
T
M
Y
V
G
S
T
S
V
Q
Site 48
S491
T
M
Y
V
G
S
T
S
V
Q
T
S
R
L
A
Site 49
S495
G
S
T
S
V
Q
T
S
R
L
A
K
S
K
M
Site 50
S500
Q
T
S
R
L
A
K
S
K
M
L
T
P
E
H
Site 51
T553
S
P
I
C
L
P
G
T
S
S
D
Y
N
L
M
Site 52
S554
P
I
C
L
P
G
T
S
S
D
Y
N
L
M
D
Site 53
S555
I
C
L
P
G
T
S
S
D
Y
N
L
M
D
G
Site 54
Y557
L
P
G
T
S
S
D
Y
N
L
M
D
G
D
L
Site 55
S568
D
G
D
L
G
L
I
S
G
W
G
R
T
E
K
Site 56
S627
G
G
E
K
G
M
D
S
C
K
G
D
S
G
G
Site 57
T645
V
Q
D
P
N
D
K
T
K
F
Y
A
A
G
L
Site 58
Y648
P
N
D
K
T
K
F
Y
A
A
G
L
V
S
W
Site 59
Y662
W
G
P
Q
C
G
T
Y
G
L
Y
T
R
V
K
Site 60
Y665
Q
C
G
T
Y
G
L
Y
T
R
V
K
N
Y
V
Site 61
Y671
L
Y
T
R
V
K
N
Y
V
D
W
I
M
K
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation