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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
5-LO (arachidonate 5-lipoxygenase)
Full Name:
Arachidonate 5-lipoxygenase
Alias:
Type:
Enzyme
Mass (Da):
77983
Number AA:
673
UniProt ID:
P09917
International Prot ID:
IPI00218916
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005641
Uniprot
OncoNet
Molecular Function:
GO:0004051
GO:0005509
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0019370
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
P
S
Y
T
V
T
V
A
T
G
S
Q
W
Site 2
S33
L
V
G
S
A
G
C
S
E
K
H
L
L
D
K
Site 3
Y43
H
L
L
D
K
P
F
Y
N
D
F
E
R
G
A
Site 4
S53
F
E
R
G
A
V
D
S
Y
D
V
T
V
D
E
Site 5
Y54
E
R
G
A
V
D
S
Y
D
V
T
V
D
E
E
Site 6
T57
A
V
D
S
Y
D
V
T
V
D
E
E
L
G
E
Site 7
Y75
V
R
I
E
K
R
K
Y
W
L
N
D
D
W
Y
Site 8
Y82
Y
W
L
N
D
D
W
Y
L
K
Y
I
T
L
K
Site 9
Y85
N
D
D
W
Y
L
K
Y
I
T
L
K
T
P
H
Site 10
T87
D
W
Y
L
K
Y
I
T
L
K
T
P
H
G
D
Site 11
T90
L
K
Y
I
T
L
K
T
P
H
G
D
Y
I
E
Site 12
Y95
L
K
T
P
H
G
D
Y
I
E
F
P
C
Y
R
Site 13
T105
F
P
C
Y
R
W
I
T
G
D
V
E
V
V
L
Site 14
T138
H
R
R
K
E
L
E
T
R
Q
K
Q
Y
R
W
Site 15
S172
P
R
D
I
Q
F
D
S
E
K
G
V
D
F
V
Site 16
Y182
G
V
D
F
V
L
N
Y
S
K
A
M
E
N
L
Site 17
S183
V
D
F
V
L
N
Y
S
K
A
M
E
N
L
F
Site 18
S216
E
K
I
F
V
K
I
S
N
T
I
S
E
R
V
Site 19
Y235
Q
E
D
L
M
F
G
Y
Q
F
L
N
G
C
N
Site 20
T250
P
V
L
I
R
R
C
T
E
L
P
E
K
L
P
Site 21
T259
L
P
E
K
L
P
V
T
T
E
M
V
E
C
S
Site 22
S266
T
T
E
M
V
E
C
S
L
E
R
Q
L
S
L
Site 23
S272
C
S
L
E
R
Q
L
S
L
E
Q
E
V
Q
Q
Site 24
T298
D
G
I
D
A
N
K
T
D
P
C
T
L
Q
F
Site 25
T302
A
N
K
T
D
P
C
T
L
Q
F
L
A
A
P
Site 26
S342
E
N
P
I
F
L
P
S
D
A
K
Y
D
W
L
Site 27
T445
Q
R
A
M
K
D
L
T
Y
A
S
L
C
F
P
Site 28
Y446
R
A
M
K
D
L
T
Y
A
S
L
C
F
P
E
Site 29
S462
I
K
A
R
G
M
E
S
K
E
D
I
P
Y
Y
Site 30
Y468
E
S
K
E
D
I
P
Y
Y
F
Y
R
D
D
G
Site 31
Y469
S
K
E
D
I
P
Y
Y
F
Y
R
D
D
G
L
Site 32
Y471
E
D
I
P
Y
Y
F
Y
R
D
D
G
L
L
V
Site 33
Y494
A
E
V
V
D
I
Y
Y
E
G
D
Q
V
V
E
Site 34
Y514
Q
D
F
V
N
D
V
Y
V
Y
G
M
R
G
R
Site 35
S523
Y
G
M
R
G
R
K
S
S
G
F
P
K
S
V
Site 36
S524
G
M
R
G
R
K
S
S
G
F
P
K
S
V
K
Site 37
S529
K
S
S
G
F
P
K
S
V
K
S
R
E
Q
L
Site 38
S532
G
F
P
K
S
V
K
S
R
E
Q
L
S
E
Y
Site 39
T571
W
I
P
N
A
P
P
T
M
R
A
P
P
P
T
Site 40
T591
T
I
E
Q
I
V
D
T
L
P
D
R
G
R
S
Site 41
S598
T
L
P
D
R
G
R
S
C
W
H
L
G
A
V
Site 42
Y621
N
E
L
F
L
G
M
Y
P
E
E
H
F
I
E
Site 43
S647
K
N
L
E
A
I
V
S
V
I
A
E
R
N
K
Site 44
Y660
N
K
K
K
Q
L
P
Y
Y
Y
L
S
P
D
R
Site 45
Y661
K
K
K
Q
L
P
Y
Y
Y
L
S
P
D
R
I
Site 46
Y662
K
K
Q
L
P
Y
Y
Y
L
S
P
D
R
I
P
Site 47
S664
Q
L
P
Y
Y
Y
L
S
P
D
R
I
P
N
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation