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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LTA4H
Full Name:
Leukotriene A-4 hydrolase
Alias:
Leukotriene A(4) hydrolase
Type:
Enzyme, hydrolase, esterase
Mass (Da):
69285
Number AA:
611
UniProt ID:
P09960
International Prot ID:
IPI00219077
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004301
GO:0004463
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006508
GO:0006629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
S
P
A
S
V
C
R
T
K
H
L
H
L
R
C
Site 2
S27
K
H
L
H
L
R
C
S
V
D
F
T
R
R
T
Site 3
T31
L
R
C
S
V
D
F
T
R
R
T
L
T
G
T
Site 4
T38
T
R
R
T
L
T
G
T
A
A
L
T
V
Q
S
Site 5
T42
L
T
G
T
A
A
L
T
V
Q
S
Q
E
D
N
Site 6
S45
T
A
A
L
T
V
Q
S
Q
E
D
N
L
R
S
Site 7
S81
Y
A
L
G
E
R
Q
S
Y
K
G
S
P
M
E
Site 8
Y82
A
L
G
E
R
Q
S
Y
K
G
S
P
M
E
I
Site 9
S85
E
R
Q
S
Y
K
G
S
P
M
E
I
S
L
P
Site 10
S90
K
G
S
P
M
E
I
S
L
P
I
A
L
S
K
Site 11
S106
Q
E
I
V
I
E
I
S
F
E
T
S
P
K
S
Site 12
S110
I
E
I
S
F
E
T
S
P
K
S
S
A
L
Q
Site 13
S113
S
F
E
T
S
P
K
S
S
A
L
Q
W
L
T
Site 14
S114
F
E
T
S
P
K
S
S
A
L
Q
W
L
T
P
Site 15
T120
S
S
A
L
Q
W
L
T
P
E
Q
T
S
G
K
Site 16
Y131
T
S
G
K
E
H
P
Y
L
F
S
Q
C
Q
A
Site 17
S152
L
P
C
Q
D
T
P
S
V
K
L
T
Y
T
A
Site 18
T156
D
T
P
S
V
K
L
T
Y
T
A
E
V
S
V
Site 19
T158
P
S
V
K
L
T
Y
T
A
E
V
S
V
P
K
Site 20
S172
K
E
L
V
A
L
M
S
A
I
R
D
G
E
T
Site 21
T179
S
A
I
R
D
G
E
T
P
D
P
E
D
P
S
Site 22
Y190
E
D
P
S
R
K
I
Y
K
F
I
Q
K
V
P
Site 23
T219
S
R
Q
I
G
P
R
T
L
V
W
S
E
K
E
Site 24
S223
G
P
R
T
L
V
W
S
E
K
E
Q
V
E
K
Site 25
S231
E
K
E
Q
V
E
K
S
A
Y
E
F
S
E
T
Site 26
Y233
E
Q
V
E
K
S
A
Y
E
F
S
E
T
E
S
Site 27
S236
E
K
S
A
Y
E
F
S
E
T
E
S
M
L
K
Site 28
T238
S
A
Y
E
F
S
E
T
E
S
M
L
K
I
A
Site 29
S240
Y
E
F
S
E
T
E
S
M
L
K
I
A
E
D
Site 30
Y252
A
E
D
L
G
G
P
Y
V
W
G
Q
Y
D
L
Site 31
S301
I
A
H
E
I
S
H
S
W
T
G
N
L
V
T
Site 32
T303
H
E
I
S
H
S
W
T
G
N
L
V
T
N
K
Site 33
Y324
L
N
E
G
H
T
V
Y
L
E
R
H
I
C
G
Site 34
S353
G
W
G
E
L
Q
N
S
V
K
T
F
G
E
T
Site 35
T356
E
L
Q
N
S
V
K
T
F
G
E
T
H
P
F
Site 36
Y379
D
I
D
P
D
V
A
Y
S
S
V
P
Y
E
K
Site 37
S381
D
P
D
V
A
Y
S
S
V
P
Y
E
K
G
F
Site 38
S416
K
A
Y
V
E
K
F
S
Y
K
S
I
T
T
D
Site 39
Y417
A
Y
V
E
K
F
S
Y
K
S
I
T
T
D
D
Site 40
S419
V
E
K
F
S
Y
K
S
I
T
T
D
D
W
K
Site 41
Y430
D
D
W
K
D
F
L
Y
S
Y
F
K
D
K
V
Site 42
Y432
W
K
D
F
L
Y
S
Y
F
K
D
K
V
D
V
Site 43
S451
D
W
N
A
W
L
Y
S
P
G
L
P
P
I
K
Site 44
Y461
L
P
P
I
K
P
N
Y
D
M
T
L
T
N
A
Site 45
T478
A
L
S
Q
R
W
I
T
A
K
E
D
D
L
N
Site 46
S486
A
K
E
D
D
L
N
S
F
N
A
T
D
L
K
Site 47
T490
D
L
N
S
F
N
A
T
D
L
K
D
L
S
S
Site 48
S497
T
D
L
K
D
L
S
S
H
Q
L
N
E
F
L
Site 49
T507
L
N
E
F
L
A
Q
T
L
Q
R
A
P
L
P
Site 50
Y525
I
K
R
M
Q
E
V
Y
N
F
N
A
I
N
N
Site 51
S581
D
L
A
A
F
D
K
S
H
D
Q
A
V
R
T
Site 52
Y589
H
D
Q
A
V
R
T
Y
Q
E
H
K
A
S
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation