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Updated November 2019
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Protein Info
Short Name:
FREM3
Full Name:
FRAS1-related extracellular matrix protein 3
Alias:
Type:
Mass (Da):
237764
Number AA:
2135
UniProt ID:
P0C091
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
G
A
S
R
H
P
T
G
T
P
R
Q
L
L
Site 2
T11
A
S
R
H
P
T
G
T
P
R
Q
L
L
V
A
Site 3
S34
P
A
L
Q
G
R
A
S
S
L
G
T
E
P
D
Site 4
S35
A
L
Q
G
R
A
S
S
L
G
T
E
P
D
P
Site 5
T38
G
R
A
S
S
L
G
T
E
P
D
P
A
L
Y
Site 6
Y45
T
E
P
D
P
A
L
Y
L
P
A
R
G
A
L
Site 7
T55
A
R
G
A
L
D
G
T
R
P
D
G
P
S
V
Site 8
S61
G
T
R
P
D
G
P
S
V
L
I
A
N
P
G
Site 9
S76
L
R
V
P
L
G
R
S
L
W
L
D
P
L
R
Site 10
T98
P
G
D
R
C
E
V
T
V
L
D
A
L
P
R
Site 11
S111
P
R
L
K
G
A
L
S
P
R
R
F
P
C
T
Site 12
T118
S
P
R
R
F
P
C
T
F
G
P
R
Q
V
Q
Site 13
Y126
F
G
P
R
Q
V
Q
Y
T
H
F
G
S
H
S
Site 14
T127
G
P
R
Q
V
Q
Y
T
H
F
G
S
H
S
P
Site 15
S131
V
Q
Y
T
H
F
G
S
H
S
P
G
R
A
R
Site 16
S133
Y
T
H
F
G
S
H
S
P
G
R
A
R
V
L
Site 17
Y145
R
V
L
L
Q
L
R
Y
D
A
P
T
H
T
L
Site 18
T149
Q
L
R
Y
D
A
P
T
H
T
L
V
L
P
F
Site 19
S183
L
V
V
E
K
L
R
S
W
S
R
A
I
D
R
Site 20
S185
V
E
K
L
R
S
W
S
R
A
I
D
R
R
V
Site 21
S197
R
R
V
L
D
F
A
S
L
K
S
G
A
T
A
Site 22
S200
L
D
F
A
S
L
K
S
G
A
T
A
T
R
R
Site 23
T205
L
K
S
G
A
T
A
T
R
R
C
R
L
T
P
Site 24
T211
A
T
R
R
C
R
L
T
P
L
P
H
E
D
G
Site 25
Y223
E
D
G
P
L
P
K
Y
G
R
L
V
D
A
V
Site 26
Y252
F
L
R
A
G
V
R
Y
Q
H
T
A
T
S
S
Site 27
T255
A
G
V
R
Y
Q
H
T
A
T
S
S
P
N
R
Site 28
T257
V
R
Y
Q
H
T
A
T
S
S
P
N
R
D
Y
Site 29
S259
Y
Q
H
T
A
T
S
S
P
N
R
D
Y
V
P
Site 30
Y264
T
S
S
P
N
R
D
Y
V
P
M
M
V
E
L
Site 31
S281
P
E
G
Q
D
A
G
S
A
G
V
L
V
R
E
Site 32
T303
I
R
G
G
A
E
N
T
P
P
R
P
S
F
M
Site 33
T312
P
R
P
S
F
M
A
T
M
M
M
E
V
D
P
Site 34
T351
F
N
I
L
N
A
P
T
H
P
P
G
H
P
G
Site 35
Y362
G
H
P
G
Q
Q
G
Y
V
V
S
T
D
D
P
Site 36
S365
G
Q
Q
G
Y
V
V
S
T
D
D
P
L
G
L
Site 37
T366
Q
Q
G
Y
V
V
S
T
D
D
P
L
G
L
P
Site 38
Y389
L
R
E
L
K
I
A
Y
Q
P
P
A
E
N
S
Site 39
S448
L
V
L
F
E
G
Q
S
R
P
L
S
S
T
H
Site 40
S452
E
G
Q
S
R
P
L
S
S
T
H
S
I
P
I
Site 41
S453
G
Q
S
R
P
L
S
S
T
H
S
I
P
I
S
Site 42
T454
Q
S
R
P
L
S
S
T
H
S
I
P
I
S
D
Site 43
S456
R
P
L
S
S
T
H
S
I
P
I
S
D
K
D
Site 44
S460
S
T
H
S
I
P
I
S
D
K
D
N
L
E
E
Site 45
Y505
L
A
A
G
R
V
V
Y
Q
H
D
G
S
N
T
Site 46
S568
Q
I
S
P
F
V
L
S
A
T
D
I
D
S
E
Site 47
T570
S
P
F
V
L
S
A
T
D
I
D
S
E
D
S
Site 48
S574
L
S
A
T
D
I
D
S
E
D
S
T
I
H
F
Site 49
T578
D
I
D
S
E
D
S
T
I
H
F
V
L
E
N
Site 50
S603
Q
W
E
L
A
P
G
S
S
H
S
G
H
Y
L
Site 51
S604
W
E
L
A
P
G
S
S
H
S
G
H
Y
L
G
Site 52
S606
L
A
P
G
S
S
H
S
G
H
Y
L
G
D
L
Site 53
S623
Q
Q
A
E
L
P
L
S
T
E
D
E
D
W
H
Site 54
Y631
T
E
D
E
D
W
H
Y
M
E
K
E
G
L
Y
Site 55
Y638
Y
M
E
K
E
G
L
Y
E
K
V
V
T
E
W
Site 56
T643
G
L
Y
E
K
V
V
T
E
W
L
Q
R
D
I
Site 57
Y657
I
M
E
G
R
L
F
Y
R
H
L
G
P
H
S
Site 58
S664
Y
R
H
L
G
P
H
S
P
Q
S
V
M
V
Q
Site 59
Y706
D
I
L
S
P
Q
L
Y
P
G
T
T
L
E
M
Site 60
T714
P
G
T
T
L
E
M
T
V
Q
E
Y
Q
L
T
Site 61
T721
T
V
Q
E
Y
Q
L
T
H
F
Q
K
N
F
L
Site 62
Y742
S
D
D
Q
N
L
W
Y
T
L
L
T
L
P
T
Site 63
T743
D
D
Q
N
L
W
Y
T
L
L
T
L
P
T
D
Site 64
Y787
V
N
Q
H
K
V
A
Y
Q
P
P
Q
K
L
G
Site 65
T803
A
P
R
V
V
Q
F
T
Y
Q
V
E
D
A
A
Site 66
S844
F
A
I
L
E
G
G
S
F
N
L
S
S
N
E
Site 67
S848
E
G
G
S
F
N
L
S
S
N
E
L
H
V
T
Site 68
T855
S
S
N
E
L
H
V
T
D
P
D
T
D
I
D
Site 69
T859
L
H
V
T
D
P
D
T
D
I
D
Q
I
V
F
Site 70
S899
Q
A
D
V
I
N
G
S
V
S
Y
Q
H
G
R
Site 71
S901
D
V
I
N
G
S
V
S
Y
Q
H
G
R
D
Q
Site 72
T909
Y
Q
H
G
R
D
Q
T
T
T
S
D
T
F
H
Site 73
T910
Q
H
G
R
D
Q
T
T
T
S
D
T
F
H
L
Site 74
T911
H
G
R
D
Q
T
T
T
S
D
T
F
H
L
E
Site 75
S912
G
R
D
Q
T
T
T
S
D
T
F
H
L
E
V
Site 76
T914
D
Q
T
T
T
S
D
T
F
H
L
E
V
S
D
Site 77
S920
D
T
F
H
L
E
V
S
D
G
V
H
H
I
P
Site 78
S942
H
P
N
V
A
N
R
S
P
R
I
S
L
R
S
Site 79
S946
A
N
R
S
P
R
I
S
L
R
S
S
S
L
L
Site 80
S949
S
P
R
I
S
L
R
S
S
S
L
L
D
V
S
Site 81
S956
S
S
S
L
L
D
V
S
I
D
V
L
E
N
K
Site 82
T1008
G
L
P
T
E
R
F
T
Q
E
D
L
I
N
G
Site 83
S1036
Q
K
Q
H
D
A
F
S
L
L
S
K
D
S
Y
Site 84
S1039
H
D
A
F
S
L
L
S
K
D
S
Y
Q
W
V
Site 85
S1042
F
S
L
L
S
K
D
S
Y
Q
W
V
V
G
N
Site 86
Y1043
S
L
L
S
K
D
S
Y
Q
W
V
V
G
N
S
Site 87
Y1080
V
G
E
S
F
I
V
Y
E
G
E
K
N
S
L
Site 88
S1086
V
Y
E
G
E
K
N
S
L
T
L
Q
H
L
H
Site 89
T1088
E
G
E
K
N
S
L
T
L
Q
H
L
H
V
E
Site 90
T1099
L
H
V
E
D
V
D
T
H
Q
D
E
L
L
C
Site 91
T1107
H
Q
D
E
L
L
C
T
V
T
S
Q
P
A
S
Site 92
T1109
D
E
L
L
C
T
V
T
S
Q
P
A
S
G
Y
Site 93
S1114
T
V
T
S
Q
P
A
S
G
Y
L
E
K
I
A
Site 94
Y1116
T
S
Q
P
A
S
G
Y
L
E
K
I
A
S
A
Site 95
S1122
G
Y
L
E
K
I
A
S
A
P
G
S
K
M
S
Site 96
S1126
K
I
A
S
A
P
G
S
K
M
S
Q
S
G
S
Site 97
S1129
S
A
P
G
S
K
M
S
Q
S
G
S
P
I
S
Site 98
S1131
P
G
S
K
M
S
Q
S
G
S
P
I
S
A
F
Site 99
S1133
S
K
M
S
Q
S
G
S
P
I
S
A
F
S
L
Site 100
S1136
S
Q
S
G
S
P
I
S
A
F
S
L
R
D
I
Site 101
S1139
G
S
P
I
S
A
F
S
L
R
D
I
Q
V
R
Site 102
Y1150
I
Q
V
R
H
I
N
Y
V
Q
S
I
H
K
G
Site 103
Y1168
Q
E
D
Q
F
T
F
Y
C
S
D
G
I
N
F
Site 104
T1231
P
N
E
H
F
Q
L
T
A
L
P
R
H
G
R
Site 105
S1247
I
Q
Q
L
A
T
G
S
Q
P
I
H
S
F
T
Site 106
S1252
T
G
S
Q
P
I
H
S
F
T
L
K
E
I
Q
Site 107
T1254
S
Q
P
I
H
S
F
T
L
K
E
I
Q
E
A
Site 108
S1262
L
K
E
I
Q
E
A
S
T
I
V
Y
E
H
D
Site 109
Y1266
Q
E
A
S
T
I
V
Y
E
H
D
D
S
E
T
Site 110
S1271
I
V
Y
E
H
D
D
S
E
T
K
E
D
S
F
Site 111
T1273
Y
E
H
D
D
S
E
T
K
E
D
S
F
E
V
Site 112
S1277
D
S
E
T
K
E
D
S
F
E
V
W
L
S
D
Site 113
S1283
D
S
F
E
V
W
L
S
D
G
K
H
T
T
H
Site 114
T1289
L
S
D
G
K
H
T
T
H
R
K
V
P
I
V
Site 115
T1304
V
T
L
V
D
D
E
T
P
H
L
T
V
N
N
Site 116
T1308
D
D
E
T
P
H
L
T
V
N
N
G
L
K
V
Site 117
T1324
K
G
H
S
E
I
I
T
N
R
I
L
K
A
T
Site 118
T1331
T
N
R
I
L
K
A
T
D
L
D
S
D
D
K
Site 119
S1335
L
K
A
T
D
L
D
S
D
D
K
S
L
S
F
Site 120
S1339
D
L
D
S
D
D
K
S
L
S
F
V
L
H
S
Site 121
S1341
D
S
D
D
K
S
L
S
F
V
L
H
S
G
P
Site 122
Y1385
I
N
R
G
L
I
C
Y
I
H
T
G
Q
E
G
Site 123
Y1414
T
L
T
D
H
Y
F
Y
V
I
G
N
L
D
S
Site 124
T1442
E
G
A
R
V
T
L
T
N
N
L
L
T
N
S
Site 125
T1447
T
L
T
N
N
L
L
T
N
S
D
I
N
S
S
Site 126
S1449
T
N
N
L
L
T
N
S
D
I
N
S
S
D
E
Site 127
S1453
L
T
N
S
D
I
N
S
S
D
E
H
H
F
S
Site 128
S1454
T
N
S
D
I
N
S
S
D
E
H
H
F
S
I
Site 129
S1460
S
S
D
E
H
H
F
S
I
T
R
A
P
S
L
Site 130
T1462
D
E
H
H
F
S
I
T
R
A
P
S
L
G
H
Site 131
S1466
F
S
I
T
R
A
P
S
L
G
H
L
E
S
S
Site 132
S1472
P
S
L
G
H
L
E
S
S
D
Y
A
G
E
P
Site 133
S1473
S
L
G
H
L
E
S
S
D
Y
A
G
E
P
I
Site 134
Y1475
G
H
L
E
S
S
D
Y
A
G
E
P
I
A
S
Site 135
S1490
F
T
Q
L
Q
L
A
S
N
K
I
S
Y
V
H
Site 136
S1494
Q
L
A
S
N
K
I
S
Y
V
H
T
S
N
D
Site 137
Y1495
L
A
S
N
K
I
S
Y
V
H
T
S
N
D
E
Site 138
T1498
N
K
I
S
Y
V
H
T
S
N
D
E
K
K
M
Site 139
S1499
K
I
S
Y
V
H
T
S
N
D
E
K
K
M
D
Site 140
S1507
N
D
E
K
K
M
D
S
F
E
F
Q
V
I
G
Site 141
T1538
D
N
K
K
P
I
L
T
I
H
R
L
T
L
Q
Site 142
T1543
I
L
T
I
H
R
L
T
L
Q
K
E
D
S
Q
Site 143
S1549
L
T
L
Q
K
E
D
S
Q
L
I
T
L
L
E
Site 144
T1553
K
E
D
S
Q
L
I
T
L
L
E
L
T
V
E
Site 145
S1562
L
E
L
T
V
E
D
S
D
T
P
D
D
L
I
Site 146
Y1584
P
M
H
G
K
I
L
Y
N
G
S
R
P
V
T
Site 147
S1587
G
K
I
L
Y
N
G
S
R
P
V
T
T
F
T
Site 148
T1591
Y
N
G
S
R
P
V
T
T
F
T
K
Q
D
L
Site 149
T1592
N
G
S
R
P
V
T
T
F
T
K
Q
D
L
N
Site 150
Y1604
D
L
N
K
N
L
I
Y
K
H
D
G
S
E
T
Site 151
S1609
L
I
Y
K
H
D
G
S
E
T
T
E
D
S
F
Site 152
T1611
Y
K
H
D
G
S
E
T
T
E
D
S
F
S
L
Site 153
S1615
G
S
E
T
T
E
D
S
F
S
L
T
V
T
D
Site 154
S1617
E
T
T
E
D
S
F
S
L
T
V
T
D
G
T
Site 155
T1619
T
E
D
S
F
S
L
T
V
T
D
G
T
H
T
Site 156
T1621
D
S
F
S
L
T
V
T
D
G
T
H
T
D
F
Site 157
Y1629
D
G
T
H
T
D
F
Y
V
L
P
D
T
A
L
Site 158
T1634
D
F
Y
V
L
P
D
T
A
L
A
T
H
K
P
Site 159
T1638
L
P
D
T
A
L
A
T
H
K
P
Q
V
M
R
Site 160
S1650
V
M
R
V
Q
I
R
S
L
D
N
R
L
P
Q
Site 161
T1659
D
N
R
L
P
Q
I
T
T
N
R
G
A
P
A
Site 162
T1660
N
R
L
P
Q
I
T
T
N
R
G
A
P
A
L
Site 163
S1681
H
M
G
F
L
I
T
S
K
S
L
K
A
E
D
Site 164
S1683
G
F
L
I
T
S
K
S
L
K
A
E
D
Q
D
Site 165
S1691
L
K
A
E
D
Q
D
S
P
H
R
L
L
K
Y
Site 166
Y1698
S
P
H
R
L
L
K
Y
K
V
T
R
G
P
E
Site 167
T1701
R
L
L
K
Y
K
V
T
R
G
P
E
H
G
F
Site 168
T1712
E
H
G
F
I
I
K
T
G
L
G
N
Q
S
T
Site 169
S1718
K
T
G
L
G
N
Q
S
T
R
V
F
T
Q
A
Site 170
T1719
T
G
L
G
N
Q
S
T
R
V
F
T
Q
A
D
Site 171
T1723
N
Q
S
T
R
V
F
T
Q
A
D
I
D
E
M
Site 172
S1733
D
I
D
E
M
K
I
S
Y
V
L
N
E
G
S
Site 173
Y1734
I
D
E
M
K
I
S
Y
V
L
N
E
G
S
N
Site 174
S1740
S
Y
V
L
N
E
G
S
N
A
S
K
D
I
F
Site 175
Y1748
N
A
S
K
D
I
F
Y
F
S
V
E
D
N
G
Site 176
S1750
S
K
D
I
F
Y
F
S
V
E
D
N
G
G
N
Site 177
T1760
D
N
G
G
N
K
L
T
N
Q
P
F
H
L
N
Site 178
Y1778
I
C
L
E
K
E
Y
Y
I
V
D
E
D
S
T
Site 179
T1790
D
S
T
F
L
E
V
T
L
T
R
R
G
Y
L
Site 180
T1792
T
F
L
E
V
T
L
T
R
R
G
Y
L
G
E
Site 181
S1801
R
G
Y
L
G
E
T
S
F
I
S
I
G
T
K
Site 182
S1804
L
G
E
T
S
F
I
S
I
G
T
K
D
E
T
Site 183
T1811
S
I
G
T
K
D
E
T
A
K
K
D
K
D
F
Site 184
T1836
N
P
G
Q
T
T
A
T
W
R
V
R
I
I
P
Site 185
Y1847
R
I
I
P
D
N
E
Y
E
T
S
E
T
F
Q
Site 186
S1850
P
D
N
E
Y
E
T
S
E
T
F
Q
I
I
L
Site 187
T1852
N
E
Y
E
T
S
E
T
F
Q
I
I
L
S
E
Site 188
T1883
V
D
P
G
D
E
S
T
V
Y
I
P
E
A
E
Site 189
Y1885
P
G
D
E
S
T
V
Y
I
P
E
A
E
Y
K
Site 190
S1907
L
L
I
P
V
R
R
S
G
D
A
S
Q
E
L
Site 191
S1911
V
R
R
S
G
D
A
S
Q
E
L
I
V
I
C
Site 192
S1924
I
C
S
T
R
Q
G
S
A
T
G
T
I
S
S
Site 193
T1926
S
T
R
Q
G
S
A
T
G
T
I
S
S
T
V
Site 194
S1936
I
S
S
T
V
L
F
S
D
Y
I
S
R
P
E
Site 195
Y1938
S
T
V
L
F
S
D
Y
I
S
R
P
E
D
H
Site 196
S1940
V
L
F
S
D
Y
I
S
R
P
E
D
H
T
S
Site 197
T1946
I
S
R
P
E
D
H
T
S
I
L
H
F
D
K
Site 198
S1947
S
R
P
E
D
H
T
S
I
L
H
F
D
K
N
Site 199
T1959
D
K
N
E
T
Q
K
T
C
Q
V
L
I
I
D
Site 200
S1968
Q
V
L
I
I
D
D
S
L
Y
E
E
E
E
S
Site 201
Y1970
L
I
I
D
D
S
L
Y
E
E
E
E
S
F
S
Site 202
S1975
S
L
Y
E
E
E
E
S
F
S
V
S
L
R
L
Site 203
S1977
Y
E
E
E
E
S
F
S
V
S
L
R
L
P
V
Site 204
S1979
E
E
E
S
F
S
V
S
L
R
L
P
V
G
G
Site 205
Y2016
L
H
F
G
D
A
E
Y
H
V
N
E
S
A
R
Site 206
Y2024
H
V
N
E
S
A
R
Y
V
E
V
C
V
W
R
Site 207
T2034
V
C
V
W
R
R
G
T
D
L
S
Q
P
S
S
Site 208
S2037
W
R
R
G
T
D
L
S
Q
P
S
S
I
A
V
Site 209
S2041
T
D
L
S
Q
P
S
S
I
A
V
R
S
R
K
Site 210
S2046
P
S
S
I
A
V
R
S
R
K
S
E
Q
E
S
Site 211
S2049
I
A
V
R
S
R
K
S
E
Q
E
S
A
E
A
Site 212
S2053
S
R
K
S
E
Q
E
S
A
E
A
G
T
D
Y
Site 213
Y2060
S
A
E
A
G
T
D
Y
V
G
I
S
R
N
L
Site 214
T2115
V
L
G
E
P
N
K
T
T
I
F
I
E
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation