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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLA2G4B
Full Name:
Cytosolic phospholipase A2 beta
Alias:
CPLA2 beta; PA24B; Phospholipase A2 group IVB
Type:
Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Phospholipase; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; EC 3.1.1.4
Mass (Da):
114120
Number AA:
UniProt ID:
P0C869
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005768
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0047498
GO:0005544
PhosphoSite+
KinaseNET
Biological Process:
GO:0019369
GO:0019722
GO:0046475
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
L
Q
A
H
R
L
P
S
K
D
L
V
T
P
S
Site 2
T29
L
P
S
K
D
L
V
T
P
S
D
C
Y
V
T
Site 3
S31
S
K
D
L
V
T
P
S
D
C
Y
V
T
L
W
Site 4
S44
L
W
L
P
T
A
C
S
H
R
L
Q
T
R
T
Site 5
T49
A
C
S
H
R
L
Q
T
R
T
V
K
N
S
S
Site 6
T51
S
H
R
L
Q
T
R
T
V
K
N
S
S
S
P
Site 7
S55
Q
T
R
T
V
K
N
S
S
S
P
V
W
N
Q
Site 8
S57
R
T
V
K
N
S
S
S
P
V
W
N
Q
S
F
Site 9
S111
A
G
E
F
R
R
E
S
F
S
L
S
P
Q
G
Site 10
S113
E
F
R
R
E
S
F
S
L
S
P
Q
G
E
G
Site 11
S115
R
R
E
S
F
S
L
S
P
Q
G
E
G
R
L
Site 12
S130
E
V
E
F
R
L
Q
S
L
A
D
R
G
E
W
Site 13
S140
D
R
G
E
W
L
V
S
N
G
V
L
V
A
R
Site 14
S164
E
E
T
G
D
Q
K
S
S
E
H
R
V
Q
L
Site 15
S184
C
E
G
P
Q
E
A
S
V
G
T
G
T
F
R
Site 16
T189
E
A
S
V
G
T
G
T
F
R
F
H
C
P
A
Site 17
S203
A
C
W
E
Q
E
L
S
I
R
L
Q
D
A
P
Site 18
S219
E
Q
L
K
A
P
L
S
A
L
P
S
G
Q
V
Site 19
S269
A
E
E
Q
A
F
L
S
R
R
K
Q
V
V
A
Site 20
Y345
T
W
A
L
A
N
L
Y
E
D
P
E
W
S
Q
Site 21
T364
G
P
T
E
L
L
K
T
Q
V
T
K
N
K
L
Site 22
S377
K
L
G
V
L
A
P
S
Q
L
Q
R
Y
R
Q
Site 23
Y394
A
E
R
A
R
L
G
Y
P
S
C
F
T
N
L
Site 24
S420
E
P
H
D
H
K
L
S
D
Q
R
E
A
L
S
Site 25
S427
S
D
Q
R
E
A
L
S
H
G
Q
N
P
L
P
Site 26
Y436
G
Q
N
P
L
P
I
Y
C
A
L
N
T
K
G
Site 27
T441
P
I
Y
C
A
L
N
T
K
G
Q
S
L
T
T
Site 28
T447
N
T
K
G
Q
S
L
T
T
F
E
F
G
E
W
Site 29
T448
T
K
G
Q
S
L
T
T
F
E
F
G
E
W
C
Site 30
Y460
E
W
C
E
F
S
P
Y
E
V
G
F
P
K
Y
Site 31
Y467
Y
E
V
G
F
P
K
Y
G
A
F
I
P
S
E
Site 32
S492
L
M
K
R
L
P
E
S
R
I
C
F
L
E
G
Site 33
Y505
E
G
I
W
S
N
L
Y
A
A
N
L
Q
D
S
Site 34
S512
Y
A
A
N
L
Q
D
S
L
Y
W
A
S
E
P
Site 35
Y514
A
N
L
Q
D
S
L
Y
W
A
S
E
P
S
Q
Site 36
S517
Q
D
S
L
Y
W
A
S
E
P
S
Q
F
W
D
Site 37
S548
L
K
I
E
E
P
P
S
T
A
G
R
I
A
E
Site 38
T549
K
I
E
E
P
P
S
T
A
G
R
I
A
E
F
Site 39
Y583
G
L
H
F
H
K
D
Y
F
Q
H
P
H
F
S
Site 40
T596
F
S
T
W
K
A
T
T
L
D
G
L
P
N
Q
Site 41
T605
D
G
L
P
N
Q
L
T
P
S
E
P
H
L
C
Site 42
S639
R
D
V
D
L
I
L
S
L
D
Y
N
L
H
G
Site 43
S669
G
I
P
F
P
P
I
S
P
S
P
E
E
Q
L
Site 44
S671
P
F
P
P
I
S
P
S
P
E
E
Q
L
Q
P
Site 45
T683
L
Q
P
R
E
C
H
T
F
S
D
P
T
C
P
Site 46
S685
P
R
E
C
H
T
F
S
D
P
T
C
P
G
A
Site 47
S702
V
L
H
F
P
L
V
S
D
S
F
R
E
Y
S
Site 48
S704
H
F
P
L
V
S
D
S
F
R
E
Y
S
A
P
Site 49
Y708
V
S
D
S
F
R
E
Y
S
A
P
G
V
R
R
Site 50
S709
S
D
S
F
R
E
Y
S
A
P
G
V
R
R
T
Site 51
T716
S
A
P
G
V
R
R
T
P
E
E
A
A
A
G
Site 52
S728
A
A
G
E
V
N
L
S
S
S
D
S
P
Y
H
Site 53
S729
A
G
E
V
N
L
S
S
S
D
S
P
Y
H
Y
Site 54
S730
G
E
V
N
L
S
S
S
D
S
P
Y
H
Y
T
Site 55
S732
V
N
L
S
S
S
D
S
P
Y
H
Y
T
K
V
Site 56
Y734
L
S
S
S
D
S
P
Y
H
Y
T
K
V
T
Y
Site 57
Y736
S
S
D
S
P
Y
H
Y
T
K
V
T
Y
S
Q
Site 58
S742
H
Y
T
K
V
T
Y
S
Q
E
D
V
D
K
L
Site 59
Y755
K
L
L
H
L
T
H
Y
N
V
C
N
N
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation