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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GLI2
Full Name:
Zinc finger protein GLI2
Alias:
Tax helper protein
Type:
Mass (Da):
167780
Number AA:
UniProt ID:
P10070
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0016563
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007411
GO:0048754
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
T
S
A
S
A
T
A
S
E
K
Q
Site 2
T8
M
E
T
S
A
S
A
T
A
S
E
K
Q
E
A
Site 3
S10
T
S
A
S
A
T
A
S
E
K
Q
E
A
K
S
Site 4
S17
S
E
K
Q
E
A
K
S
G
I
L
E
A
A
G
Site 5
Y75
H
Q
E
G
R
Y
H
Y
E
P
H
S
V
H
G
Site 6
S104
D
I
S
L
I
R
L
S
P
H
P
A
G
P
G
Site 7
S113
H
P
A
G
P
G
E
S
P
F
N
A
P
H
P
Site 8
Y129
V
N
P
H
M
E
H
Y
L
R
S
V
H
S
S
Site 9
S132
H
M
E
H
Y
L
R
S
V
H
S
S
P
T
L
Site 10
S135
H
Y
L
R
S
V
H
S
S
P
T
L
S
M
I
Site 11
S136
Y
L
R
S
V
H
S
S
P
T
L
S
M
I
S
Site 12
T138
R
S
V
H
S
S
P
T
L
S
M
I
S
A
A
Site 13
S143
S
P
T
L
S
M
I
S
A
A
R
G
L
S
P
Site 14
S149
I
S
A
A
R
G
L
S
P
A
D
V
A
Q
E
Site 15
T171
F
G
L
P
A
P
G
T
T
P
S
D
Y
Y
H
Site 16
T172
G
L
P
A
P
G
T
T
P
S
D
Y
Y
H
Q
Site 17
S174
P
A
P
G
T
T
P
S
D
Y
Y
H
Q
M
T
Site 18
Y176
P
G
T
T
P
S
D
Y
Y
H
Q
M
T
L
V
Site 19
Y177
G
T
T
P
S
D
Y
Y
H
Q
M
T
L
V
A
Site 20
Y209
S
A
P
H
L
H
D
Y
L
N
P
V
D
V
S
Site 21
S216
Y
L
N
P
V
D
V
S
R
F
S
S
P
R
V
Site 22
S219
P
V
D
V
S
R
F
S
S
P
R
V
T
P
R
Site 23
S220
V
D
V
S
R
F
S
S
P
R
V
T
P
R
L
Site 24
T224
R
F
S
S
P
R
V
T
P
R
L
S
R
K
R
Site 25
S228
P
R
V
T
P
R
L
S
R
K
R
A
L
S
I
Site 26
S234
L
S
R
K
R
A
L
S
I
S
P
L
S
D
A
Site 27
S236
R
K
R
A
L
S
I
S
P
L
S
D
A
S
L
Site 28
S239
A
L
S
I
S
P
L
S
D
A
S
L
D
L
Q
Site 29
S242
I
S
P
L
S
D
A
S
L
D
L
Q
R
M
I
Site 30
S252
L
Q
R
M
I
R
T
S
P
N
S
L
V
A
Y
Site 31
S255
M
I
R
T
S
P
N
S
L
V
A
Y
I
N
N
Site 32
Y259
S
P
N
S
L
V
A
Y
I
N
N
S
R
S
S
Site 33
S263
L
V
A
Y
I
N
N
S
R
S
S
S
A
A
S
Site 34
S265
A
Y
I
N
N
S
R
S
S
S
A
A
S
G
S
Site 35
S266
Y
I
N
N
S
R
S
S
S
A
A
S
G
S
Y
Site 36
S267
I
N
N
S
R
S
S
S
A
A
S
G
S
Y
G
Site 37
S270
S
R
S
S
S
A
A
S
G
S
Y
G
H
L
S
Site 38
S272
S
S
S
A
A
S
G
S
Y
G
H
L
S
A
G
Site 39
S277
S
G
S
Y
G
H
L
S
A
G
A
L
S
P
A
Site 40
S301
V
A
Y
Q
Q
I
L
S
Q
Q
R
G
L
G
S
Site 41
S308
S
Q
Q
R
G
L
G
S
A
F
G
H
T
P
P
Site 42
T313
L
G
S
A
F
G
H
T
P
P
L
I
Q
P
S
Site 43
S320
T
P
P
L
I
Q
P
S
P
T
F
L
A
Q
Q
Site 44
T322
P
L
I
Q
P
S
P
T
F
L
A
Q
Q
P
M
Site 45
T337
A
L
T
S
I
N
A
T
P
T
Q
L
S
S
S
Site 46
T339
T
S
I
N
A
T
P
T
Q
L
S
S
S
S
N
Site 47
S342
N
A
T
P
T
Q
L
S
S
S
S
N
C
L
S
Site 48
S343
A
T
P
T
Q
L
S
S
S
S
N
C
L
S
D
Site 49
S344
T
P
T
Q
L
S
S
S
S
N
C
L
S
D
T
Site 50
S345
P
T
Q
L
S
S
S
S
N
C
L
S
D
T
N
Site 51
S349
S
S
S
S
N
C
L
S
D
T
N
Q
N
K
Q
Site 52
T351
S
S
N
C
L
S
D
T
N
Q
N
K
Q
S
S
Site 53
S358
T
N
Q
N
K
Q
S
S
E
S
A
V
S
S
T
Site 54
S360
Q
N
K
Q
S
S
E
S
A
V
S
S
T
V
N
Site 55
S363
Q
S
S
E
S
A
V
S
S
T
V
N
P
V
A
Site 56
T379
H
K
R
S
K
V
K
T
E
P
E
G
L
R
P
Site 57
S388
P
E
G
L
R
P
A
S
P
L
A
L
T
Q
G
Site 58
T393
P
A
S
P
L
A
L
T
Q
G
Q
V
S
G
H
Site 59
S398
A
L
T
Q
G
Q
V
S
G
H
G
S
C
G
C
Site 60
Y435
Q
E
A
E
V
V
I
Y
E
T
N
C
H
W
E
Site 61
T450
D
C
T
K
E
Y
D
T
Q
E
Q
L
V
H
H
Site 62
Y488
Q
K
P
F
K
A
Q
Y
M
L
V
V
H
M
R
Site 63
T498
V
V
H
M
R
R
H
T
G
E
K
P
H
K
C
Site 64
T506
G
E
K
P
H
K
C
T
F
E
G
C
S
K
A
Site 65
S515
E
G
C
S
K
A
Y
S
R
L
E
N
L
K
T
Site 66
T522
S
R
L
E
N
L
K
T
H
L
R
S
H
T
G
Site 67
S526
N
L
K
T
H
L
R
S
H
T
G
E
K
P
Y
Site 68
T528
K
T
H
L
R
S
H
T
G
E
K
P
Y
V
C
Site 69
Y533
S
H
T
G
E
K
P
Y
V
C
E
H
E
G
C
Site 70
S548
N
K
A
F
S
N
A
S
D
R
A
K
H
Q
N
Site 71
Y564
T
H
S
N
E
K
P
Y
I
C
K
I
P
G
C
Site 72
Y575
I
P
G
C
T
K
R
Y
T
D
P
S
S
L
R
Site 73
T576
P
G
C
T
K
R
Y
T
D
P
S
S
L
R
K
Site 74
S579
T
K
R
Y
T
D
P
S
S
L
R
K
H
V
K
Site 75
S580
K
R
Y
T
D
P
S
S
L
R
K
H
V
K
T
Site 76
T587
S
L
R
K
H
V
K
T
V
H
G
P
D
A
H
Site 77
T607
R
N
D
V
H
L
R
T
P
L
L
K
E
N
G
Site 78
S616
L
L
K
E
N
G
D
S
E
A
G
T
E
P
G
Site 79
T620
N
G
D
S
E
A
G
T
E
P
G
G
P
E
S
Site 80
S627
T
E
P
G
G
P
E
S
T
E
A
S
S
T
S
Site 81
T628
E
P
G
G
P
E
S
T
E
A
S
S
T
S
Q
Site 82
S631
G
P
E
S
T
E
A
S
S
T
S
Q
A
V
E
Site 83
S634
S
T
E
A
S
S
T
S
Q
A
V
E
D
C
L
Site 84
T648
L
H
V
R
A
I
K
T
E
S
S
G
L
C
Q
Site 85
S651
R
A
I
K
T
E
S
S
G
L
C
Q
S
S
P
Site 86
S656
E
S
S
G
L
C
Q
S
S
P
G
A
Q
S
S
Site 87
S657
S
S
G
L
C
Q
S
S
P
G
A
Q
S
S
C
Site 88
S662
Q
S
S
P
G
A
Q
S
S
C
S
S
E
P
S
Site 89
S663
S
S
P
G
A
Q
S
S
C
S
S
E
P
S
P
Site 90
S665
P
G
A
Q
S
S
C
S
S
E
P
S
P
L
G
Site 91
S666
G
A
Q
S
S
C
S
S
E
P
S
P
L
G
S
Site 92
S669
S
S
C
S
S
E
P
S
P
L
G
S
A
P
N
Site 93
S673
S
E
P
S
P
L
G
S
A
P
N
N
D
S
G
Site 94
S679
G
S
A
P
N
N
D
S
G
V
E
M
P
G
T
Site 95
T686
S
G
V
E
M
P
G
T
G
P
G
S
L
G
D
Site 96
T695
P
G
S
L
G
D
L
T
A
L
D
D
T
P
P
Site 97
T700
D
L
T
A
L
D
D
T
P
P
G
A
D
T
S
Site 98
S707
T
P
P
G
A
D
T
S
A
L
A
A
P
S
A
Site 99
T725
Q
L
R
K
H
M
T
T
M
H
R
F
E
Q
L
Site 100
S739
L
K
K
E
K
L
K
S
L
K
D
S
C
S
W
Site 101
S743
K
L
K
S
L
K
D
S
C
S
W
A
G
P
T
Site 102
S745
K
S
L
K
D
S
C
S
W
A
G
P
T
P
H
Site 103
T750
S
C
S
W
A
G
P
T
P
H
T
R
N
T
K
Site 104
T756
P
T
P
H
T
R
N
T
K
L
P
P
L
P
G
Site 105
S764
K
L
P
P
L
P
G
S
G
S
I
L
E
N
F
Site 106
S766
P
P
L
P
G
S
G
S
I
L
E
N
F
S
G
Site 107
S772
G
S
I
L
E
N
F
S
G
S
G
G
G
G
P
Site 108
S774
I
L
E
N
F
S
G
S
G
G
G
G
P
A
G
Site 109
S789
L
L
P
N
P
R
L
S
E
L
S
A
S
E
V
Site 110
S792
N
P
R
L
S
E
L
S
A
S
E
V
T
M
L
Site 111
S794
R
L
S
E
L
S
A
S
E
V
T
M
L
S
Q
Site 112
S800
A
S
E
V
T
M
L
S
Q
L
Q
E
R
R
D
Site 113
S808
Q
L
Q
E
R
R
D
S
S
T
S
T
V
S
S
Site 114
S809
L
Q
E
R
R
D
S
S
T
S
T
V
S
S
A
Site 115
T810
Q
E
R
R
D
S
S
T
S
T
V
S
S
A
Y
Site 116
S811
E
R
R
D
S
S
T
S
T
V
S
S
A
Y
T
Site 117
T812
R
R
D
S
S
T
S
T
V
S
S
A
Y
T
V
Site 118
S814
D
S
S
T
S
T
V
S
S
A
Y
T
V
S
R
Site 119
S815
S
S
T
S
T
V
S
S
A
Y
T
V
S
R
R
Site 120
T818
S
T
V
S
S
A
Y
T
V
S
R
R
S
S
G
Site 121
S820
V
S
S
A
Y
T
V
S
R
R
S
S
G
I
S
Site 122
S823
A
Y
T
V
S
R
R
S
S
G
I
S
P
Y
F
Site 123
S824
Y
T
V
S
R
R
S
S
G
I
S
P
Y
F
S
Site 124
S827
S
R
R
S
S
G
I
S
P
Y
F
S
S
R
R
Site 125
Y829
R
S
S
G
I
S
P
Y
F
S
S
R
R
S
S
Site 126
S831
S
G
I
S
P
Y
F
S
S
R
R
S
S
E
A
Site 127
S832
G
I
S
P
Y
F
S
S
R
R
S
S
E
A
S
Site 128
S835
P
Y
F
S
S
R
R
S
S
E
A
S
P
L
G
Site 129
S836
Y
F
S
S
R
R
S
S
E
A
S
P
L
G
A
Site 130
S839
S
R
R
S
S
E
A
S
P
L
G
A
G
R
P
Site 131
S850
A
G
R
P
H
N
A
S
S
A
D
S
Y
D
P
Site 132
S851
G
R
P
H
N
A
S
S
A
D
S
Y
D
P
I
Site 133
S854
H
N
A
S
S
A
D
S
Y
D
P
I
S
T
D
Site 134
Y855
N
A
S
S
A
D
S
Y
D
P
I
S
T
D
A
Site 135
S859
A
D
S
Y
D
P
I
S
T
D
A
S
R
R
S
Site 136
T860
D
S
Y
D
P
I
S
T
D
A
S
R
R
S
S
Site 137
S863
D
P
I
S
T
D
A
S
R
R
S
S
E
A
S
Site 138
S866
S
T
D
A
S
R
R
S
S
E
A
S
Q
C
S
Site 139
S867
T
D
A
S
R
R
S
S
E
A
S
Q
C
S
G
Site 140
S870
S
R
R
S
S
E
A
S
Q
C
S
G
G
S
G
Site 141
S873
S
S
E
A
S
Q
C
S
G
G
S
G
L
L
N
Site 142
T882
G
S
G
L
L
N
L
T
P
A
Q
Q
Y
S
L
Site 143
S888
L
T
P
A
Q
Q
Y
S
L
R
A
K
Y
A
A
Site 144
Y893
Q
Y
S
L
R
A
K
Y
A
A
A
T
G
G
P
Site 145
T903
A
T
G
G
P
P
P
T
P
L
P
G
L
E
R
Site 146
S941
P
L
G
P
R
R
G
S
D
G
P
T
Y
G
H
Site 147
T945
R
R
G
S
D
G
P
T
Y
G
H
G
H
A
G
Site 148
Y946
R
G
S
D
G
P
T
Y
G
H
G
H
A
G
A
Site 149
S970
G
G
G
A
R
R
A
S
D
P
V
R
R
P
D
Site 150
S980
V
R
R
P
D
A
L
S
L
P
R
V
Q
R
F
Site 151
S989
P
R
V
Q
R
F
H
S
T
H
N
V
N
P
G
Site 152
S1011
R
R
G
L
R
L
Q
S
H
P
S
T
D
G
G
Site 153
S1014
L
R
L
Q
S
H
P
S
T
D
G
G
L
A
R
Site 154
T1015
R
L
Q
S
H
P
S
T
D
G
G
L
A
R
G
Site 155
Y1024
G
G
L
A
R
G
A
Y
S
P
R
P
P
S
I
Site 156
S1025
G
L
A
R
G
A
Y
S
P
R
P
P
S
I
S
Site 157
S1030
A
Y
S
P
R
P
P
S
I
S
E
N
V
A
M
Site 158
S1032
S
P
R
P
P
S
I
S
E
N
V
A
M
E
A
Site 159
T1082
S
G
A
L
D
E
G
T
G
Q
V
Y
P
T
E
Site 160
Y1086
D
E
G
T
G
Q
V
Y
P
T
E
S
T
G
F
Site 161
T1088
G
T
G
Q
V
Y
P
T
E
S
T
G
F
S
D
Site 162
S1090
G
Q
V
Y
P
T
E
S
T
G
F
S
D
N
P
Site 163
S1094
P
T
E
S
T
G
F
S
D
N
P
R
L
P
S
Site 164
S1101
S
D
N
P
R
L
P
S
P
G
L
H
G
Q
R
Site 165
S1115
R
R
M
V
A
A
D
S
N
V
G
P
S
A
P
Site 166
S1136
L
G
F
G
A
P
S
S
L
N
K
N
N
M
P
Site 167
S1159
G
T
V
D
A
L
A
S
Q
V
K
P
P
P
F
Site 168
Y1183
Q
K
P
A
F
G
Q
Y
P
G
Y
S
P
Q
G
Site 169
Y1186
A
F
G
Q
Y
P
G
Y
S
P
Q
G
L
Q
A
Site 170
S1187
F
G
Q
Y
P
G
Y
S
P
Q
G
L
Q
A
S
Site 171
S1194
S
P
Q
G
L
Q
A
S
P
G
G
L
D
S
T
Site 172
S1200
A
S
P
G
G
L
D
S
T
Q
P
H
L
Q
P
Site 173
T1201
S
P
G
G
L
D
S
T
Q
P
H
L
Q
P
R
Site 174
S1209
Q
P
H
L
Q
P
R
S
G
A
P
S
Q
G
I
Site 175
S1213
Q
P
R
S
G
A
P
S
Q
G
I
P
R
V
N
Site 176
Y1221
Q
G
I
P
R
V
N
Y
M
Q
Q
L
R
Q
P
Site 177
S1232
L
R
Q
P
V
A
G
S
Q
C
P
G
M
T
T
Site 178
T1238
G
S
Q
C
P
G
M
T
T
T
M
S
P
H
A
Site 179
Y1247
T
M
S
P
H
A
C
Y
G
Q
V
H
P
Q
L
Site 180
S1255
G
Q
V
H
P
Q
L
S
P
S
T
I
S
G
A
Site 181
S1257
V
H
P
Q
L
S
P
S
T
I
S
G
A
L
N
Site 182
T1258
H
P
Q
L
S
P
S
T
I
S
G
A
L
N
Q
Site 183
S1269
A
L
N
Q
F
P
Q
S
C
S
N
M
P
A
K
Site 184
T1294
E
V
A
P
D
P
T
T
M
G
N
R
H
R
E
Site 185
S1320
P
P
P
H
P
V
Q
S
Y
P
Q
Q
S
H
H
Site 186
Y1321
P
P
H
P
V
Q
S
Y
P
Q
Q
S
H
H
L
Site 187
S1325
V
Q
S
Y
P
Q
Q
S
H
H
L
A
A
S
M
Site 188
S1331
Q
S
H
H
L
A
A
S
M
S
Q
E
G
Y
H
Site 189
S1333
H
H
L
A
A
S
M
S
Q
E
G
Y
H
Q
V
Site 190
Y1337
A
S
M
S
Q
E
G
Y
H
Q
V
P
S
L
L
Site 191
S1342
E
G
Y
H
Q
V
P
S
L
L
P
A
R
Q
P
Site 192
T1356
P
G
F
M
E
P
Q
T
G
P
M
G
V
A
T
Site 193
S1378
P
R
P
P
L
E
P
S
P
T
G
R
H
R
G
Site 194
T1380
P
P
L
E
P
S
P
T
G
R
H
R
G
V
R
Site 195
Y1395
A
V
Q
Q
Q
L
A
Y
A
R
A
T
G
H
A
Site 196
T1412
A
M
P
S
S
Q
E
T
A
E
A
V
P
K
G
Site 197
S1426
G
A
M
G
N
M
G
S
V
P
P
Q
P
P
P
Site 198
Y1454
Y
Y
G
Q
I
H
M
Y
E
Q
D
G
G
L
E
Site 199
S1465
G
G
L
E
N
L
G
S
C
Q
V
M
R
S
Q
Site 200
S1471
G
S
C
Q
V
M
R
S
Q
P
P
Q
P
Q
A
Site 201
S1482
Q
P
Q
A
C
Q
D
S
I
Q
P
Q
P
L
P
Site 202
S1490
I
Q
P
Q
P
L
P
S
P
G
V
N
Q
V
S
Site 203
S1497
S
P
G
V
N
Q
V
S
S
T
V
D
S
Q
L
Site 204
S1498
P
G
V
N
Q
V
S
S
T
V
D
S
Q
L
L
Site 205
T1499
G
V
N
Q
V
S
S
T
V
D
S
Q
L
L
E
Site 206
S1502
Q
V
S
S
T
V
D
S
Q
L
L
E
A
P
Q
Site 207
S1522
I
M
D
D
G
D
H
S
S
L
F
S
G
A
L
Site 208
S1523
M
D
D
G
D
H
S
S
L
F
S
G
A
L
S
Site 209
S1526
G
D
H
S
S
L
F
S
G
A
L
S
P
S
L
Site 210
S1536
L
S
P
S
L
L
H
S
L
S
Q
N
S
S
R
Site 211
S1538
P
S
L
L
H
S
L
S
Q
N
S
S
R
L
T
Site 212
S1541
L
H
S
L
S
Q
N
S
S
R
L
T
T
P
R
Site 213
S1542
H
S
L
S
Q
N
S
S
R
L
T
T
P
R
N
Site 214
T1545
S
Q
N
S
S
R
L
T
T
P
R
N
S
L
T
Site 215
T1546
Q
N
S
S
R
L
T
T
P
R
N
S
L
T
L
Site 216
S1550
R
L
T
T
P
R
N
S
L
T
L
P
S
I
P
Site 217
T1552
T
T
P
R
N
S
L
T
L
P
S
I
P
A
G
Site 218
S1555
R
N
S
L
T
L
P
S
I
P
A
G
I
S
N
Site 219
T1573
G
D
M
S
S
M
L
T
S
L
A
E
E
S
K
Site 220
S1574
D
M
S
S
M
L
T
S
L
A
E
E
S
K
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation