PhosphoNET

           
Protein Info 
   
Short Name:  A-Raf
Full Name:  Serine/threonine-protein kinase A-Raf
Alias:  ARAF; A-RAF; ARAF1; A-raf-1; EC 2.7.11.1; Kinase A-Raf; PKS; PKS2; Proto-oncogene Pks; Raf; V-raf murine sarcoma 3611 viral oncogene
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; RAF family
Mass (Da):  67585
Number AA:  606
UniProt ID:  P10398
International Prot ID:  IPI00020578
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0007242  GO:0006468   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S15PANGAEPSRAVGTVK
Site 2T20EPSRAVGTVKVYLPN
Site 3Y24AVGTVKVYLPNKQRT
Site 4T34NKQRTVVTVRDGMSV
Site 5S40VTVRDGMSVYDSLDK
Site 6Y42VRDGMSVYDSLDKAL
Site 7S44DGMSVYDSLDKALKV
Site 8Y62NQDCCVVYRLIKGRK
Site 9T70RLIKGRKTVTAWDTA
Site 10T97VLEDVPLTMHNFVRK
Site 11Y155STNRQQFYHSVQDLS
Site 12S157NRQQFYHSVQDLSGG
Site 13S162YHSVQDLSGGSRQHE
Site 14S172SRQHEAPSNRPLNEL
Site 15T181RPLNELLTPQGPSPR
Site 16S186LLTPQGPSPRTQHCD
Site 17T189PQGPSPRTQHCDPEH
Site 18S212APLQRIRSTSTPNVH
Site 19T213PLQRIRSTSTPNVHM
Site 20S214LQRIRSTSTPNVHMV
Site 21T215QRIRSTSTPNVHMVS
Site 22S222TPNVHMVSTTAPMDS
Site 23T223PNVHMVSTTAPMDSN
Site 24T224NVHMVSTTAPMDSNL
Site 25S229STTAPMDSNLIQLTG
Site 26T235DSNLIQLTGQSFSTD
Site 27S240QLTGQSFSTDAAGSR
Site 28S246FSTDAAGSRGGSDGT
Site 29S250AAGSRGGSDGTPRGS
Site 30T253SRGGSDGTPRGSPSP
Site 31S257SDGTPRGSPSPASVS
Site 32S259GTPRGSPSPASVSSG
Site 33S262RGSPSPASVSSGRKS
Site 34S264SPSPASVSSGRKSPH
Site 35S265PSPASVSSGRKSPHS
Site 36S269SVSSGRKSPHSKSPA
Site 37S272SGRKSPHSKSPAEQR
Site 38S274RKSPHSKSPAEQRER
Site 39S283AEQRERKSLADDKKK
Site 40Y296KKVKNLGYRDSGYYW
Site 41S299KNLGYRDSGYYWEVP
Site 42Y301LGYRDSGYYWEVPPS
Site 43Y302GYRDSGYYWEVPPSE
Site 44S308YYWEVPPSEVQLLKR
Site 45T318QLLKRIGTGSFGTVF
Site 46S320LKRIGTGSFGTVFRG
Site 47T323IGTGSFGTVFRGRWH
Site 48S341AVKVLKVSQPTAEQA
Site 49T344VLKVSQPTAEQAQAF
Site 50T361EMQVLRKTRHVNILL
Site 51T382RPGFAIITQWCEGSS
Site 52T413LIDVARQTAQGMDYL
Site 53Y419QTAQGMDYLHAKNII
Site 54S432IIHRDLKSNNIFLHE
Site 55T442IFLHEGLTVKIGDFG
Site 56T452IGDFGLATVKTRWSG
Site 57T455FGLATVKTRWSGAQP
Site 58S458ATVKTRWSGAQPLEQ
Site 59S467AQPLEQPSGSVLWMA
Site 60S469PLEQPSGSVLWMAAE
Site 61Y486RMQDPNPYSFQSDVY
Site 62S487MQDPNPYSFQSDVYA
Site 63S510MTGSLPYSHIGCRDQ
Site 64Y526IFMVGRGYLSPDLSK
Site 65S528MVGRGYLSPDLSKIS
Site 66S532GYLSPDLSKISSNCP
Site 67S535SPDLSKISSNCPKAM
Site 68S536PDLSKISSNCPKAMR
Site 69S547KAMRRLLSDCLKFQR
Site 70S573TIELLQRSLPKIERS
Site 71S580SLPKIERSASEPSLH
Site 72S582PKIERSASEPSLHRT
Site 73S585ERSASEPSLHRTQAD
Site 74T589SEPSLHRTQADELPA
Site 75S600ELPACLLSAARLVP_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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