KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TGFB3
Full Name:
Transforming growth factor beta-3
Alias:
ARVD; TGF-beta-3
Type:
Secreted protein - Growth factor
Mass (Da):
47328
Number AA:
412
UniProt ID:
P10600
International Prot ID:
IPI00021780
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031012
GO:0031093
Uniprot
OncoNet
Molecular Function:
GO:0008083
GO:0042802
GO:0050431
PhosphoSite+
KinaseNET
Biological Process:
GO:0016049
GO:0045216
GO:0070483
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
A
I
R
G
Q
I
L
S
K
L
R
L
T
S
P
Site 2
T54
I
L
S
K
L
R
L
T
S
P
P
E
P
T
V
Site 3
S55
L
S
K
L
R
L
T
S
P
P
E
P
T
V
M
Site 4
T60
L
T
S
P
P
E
P
T
V
M
T
H
V
P
Y
Site 5
Y73
P
Y
Q
V
L
A
L
Y
N
S
T
R
E
L
L
Site 6
S75
Q
V
L
A
L
Y
N
S
T
R
E
L
L
E
E
Site 7
T92
G
E
R
E
E
G
C
T
Q
E
N
T
E
S
E
Site 8
T96
E
G
C
T
Q
E
N
T
E
S
E
Y
Y
A
K
Site 9
Y100
Q
E
N
T
E
S
E
Y
Y
A
K
E
I
H
K
Site 10
Y101
E
N
T
E
S
E
Y
Y
A
K
E
I
H
K
F
Site 11
S138
V
F
R
F
N
V
S
S
V
E
K
N
R
T
N
Site 12
S160
V
L
R
V
P
N
P
S
S
K
R
N
E
Q
R
Site 13
S161
L
R
V
P
N
P
S
S
K
R
N
E
Q
R
I
Site 14
Y185
E
H
I
A
K
Q
R
Y
I
G
G
K
N
L
P
Site 15
T196
K
N
L
P
T
R
G
T
A
E
W
L
S
F
D
Site 16
S201
R
G
T
A
E
W
L
S
F
D
V
T
D
T
V
Site 17
T205
E
W
L
S
F
D
V
T
D
T
V
R
E
W
L
Site 18
T207
L
S
F
D
V
T
D
T
V
R
E
W
L
L
R
Site 19
S217
E
W
L
L
R
R
E
S
N
L
G
L
E
I
S
Site 20
T304
R
K
K
R
A
L
D
T
N
Y
C
F
R
N
L
Site 21
Y306
K
R
A
L
D
T
N
Y
C
F
R
N
L
E
E
Site 22
Y321
N
C
C
V
R
P
L
Y
I
D
F
R
Q
D
L
Site 23
Y339
W
V
H
E
P
K
G
Y
Y
A
N
F
C
S
G
Site 24
Y340
V
H
E
P
K
G
Y
Y
A
N
F
C
S
G
P
Site 25
Y350
F
C
S
G
P
C
P
Y
L
R
S
A
D
T
T
Site 26
T357
Y
L
R
S
A
D
T
T
H
S
T
V
L
G
L
Site 27
S359
R
S
A
D
T
T
H
S
T
V
L
G
L
Y
N
Site 28
Y365
H
S
T
V
L
G
L
Y
N
T
L
N
P
E
A
Site 29
S373
N
T
L
N
P
E
A
S
A
S
P
C
C
V
P
Site 30
S375
L
N
P
E
A
S
A
S
P
C
C
V
P
Q
D
Site 31
T387
P
Q
D
L
E
P
L
T
I
L
Y
Y
V
G
R
Site 32
T395
I
L
Y
Y
V
G
R
T
P
K
V
E
Q
L
S
Site 33
S402
T
P
K
V
E
Q
L
S
N
M
V
V
K
S
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation