KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CTSA
Full Name:
Lysosomal protective protein
Alias:
Carboxypeptidase C;Carboxypeptidase L;Cathepsin A;Protective protein cathepsin A;Protective protein for beta-galactosidase
Type:
Mass (Da):
54466
Number AA:
480
UniProt ID:
P10619
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
P
G
L
A
K
Q
P
S
F
R
Q
Y
S
G
Y
Site 2
Y50
K
Q
P
S
F
R
Q
Y
S
G
Y
L
K
G
S
Site 3
S51
Q
P
S
F
R
Q
Y
S
G
Y
L
K
G
S
G
Site 4
Y53
S
F
R
Q
Y
S
G
Y
L
K
G
S
G
S
K
Site 5
S57
Y
S
G
Y
L
K
G
S
G
S
K
H
L
H
Y
Site 6
Y64
S
G
S
K
H
L
H
Y
W
F
V
E
S
Q
K
Site 7
S76
S
Q
K
D
P
E
N
S
P
V
V
L
W
L
N
Site 8
S90
N
G
G
P
G
C
S
S
L
D
G
L
L
T
E
Site 9
T109
L
V
Q
P
D
G
V
T
L
E
Y
N
P
Y
S
Site 10
Y112
P
D
G
V
T
L
E
Y
N
P
Y
S
W
N
L
Site 11
Y115
V
T
L
E
Y
N
P
Y
S
W
N
L
I
A
N
Site 12
S135
S
P
A
G
V
G
F
S
Y
S
D
D
K
F
Y
Site 13
Y136
P
A
G
V
G
F
S
Y
S
D
D
K
F
Y
A
Site 14
S137
A
G
V
G
F
S
Y
S
D
D
K
F
Y
A
T
Site 15
Y142
S
Y
S
D
D
K
F
Y
A
T
N
D
T
E
V
Site 16
T147
K
F
Y
A
T
N
D
T
E
V
A
Q
S
N
F
Site 17
S152
N
D
T
E
V
A
Q
S
N
F
E
A
L
Q
D
Site 18
Y167
F
F
R
L
F
P
E
Y
K
N
N
K
L
F
L
Site 19
S210
A
V
G
N
G
L
S
S
Y
E
Q
N
D
N
S
Site 20
Y211
V
G
N
G
L
S
S
Y
E
Q
N
D
N
S
L
Site 21
Y220
Q
N
D
N
S
L
V
Y
F
A
Y
Y
H
G
L
Site 22
Y249
S
Q
N
K
C
N
F
Y
D
N
K
D
L
E
C
Site 23
S287
P
C
A
G
G
V
P
S
H
F
R
Y
E
K
D
Site 24
Y291
G
V
P
S
H
F
R
Y
E
K
D
T
V
V
V
Site 25
T295
H
F
R
Y
E
K
D
T
V
V
V
Q
D
L
G
Site 26
T334
M
D
P
P
C
T
N
T
T
A
A
S
T
Y
L
Site 27
Y345
S
T
Y
L
N
N
P
Y
V
R
K
A
L
N
I
Site 28
Y370
N
F
L
V
N
L
Q
Y
R
R
L
Y
R
S
M
Site 29
Y374
N
L
Q
Y
R
R
L
Y
R
S
M
N
S
Q
Y
Site 30
S376
Q
Y
R
R
L
Y
R
S
M
N
S
Q
Y
L
K
Site 31
S379
R
L
Y
R
S
M
N
S
Q
Y
L
K
L
L
S
Site 32
Y381
Y
R
S
M
N
S
Q
Y
L
K
L
L
S
S
Q
Site 33
S387
Q
Y
L
K
L
L
S
S
Q
K
Y
Q
I
L
L
Site 34
Y390
K
L
L
S
S
Q
K
Y
Q
I
L
L
Y
N
G
Site 35
Y395
Q
K
Y
Q
I
L
L
Y
N
G
D
V
D
M
A
Site 36
Y430
R
R
P
W
L
V
K
Y
G
D
S
G
E
Q
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation