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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2C8
Full Name:
Cytochrome P450 2C8
Alias:
CP2C8; CPC8; CYPIIC8; Cytochrome P450, family 2, subfamily C, polypeptide 8; EC 1.14.14.1; P450 IIC2; P450 MP-12/MP-20; Phenytoin 4-hydroxylase
Type:
Enzyme - Monooxygenase. Cytochrome P450 family; Membrane, Endoplasmic reticulum membrane protein
Mass (Da):
55825
Number AA:
490
UniProt ID:
P10632
International Prot ID:
IPI00290301
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
F
S
L
W
R
Q
S
C
R
R
R
K
L
P
Site 2
T34
R
K
L
P
P
G
P
T
P
L
P
I
I
G
N
Site 3
S53
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Site 4
S95
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
Site 5
S100
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
Site 6
S103
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
Site 7
S115
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
Site 8
S127
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
Site 9
T129
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
Site 10
T130
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
Site 11
S140
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
Site 12
T159
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
Site 13
S162
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
Site 14
Y189
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
Site 15
T196
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
Site 16
T229
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
Site 17
S242
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
Site 18
Y243
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
Site 19
S254
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
Site 20
S280
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
Site 21
T304
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
Site 22
T305
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
Site 23
S336
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
Site 24
Y347
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
Site 25
T348
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Site 26
Y358
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
Site 27
S359
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
Site 28
T374
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
Site 29
Y379
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
Site 30
Y424
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
Site 31
S460
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation