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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2D6
Full Name:
Cytochrome P450 2D6
Alias:
CP2D6; CPD6; CYP2D; CYP2D@; CYP2DL1; CYPIID6; Cytochrome P450, family 2, subfamily D, polypeptide 6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase; P450C2D; P450-DB1
Type:
Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; EC 1.14.14.1
Mass (Da):
55751
Number AA:
497
UniProt ID:
P10635
International Prot ID:
IPI00456699
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0009822
GO:0042737
GO:0016098
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y33
R
Q
R
W
A
A
R
Y
P
P
G
P
L
P
L
Site 2
Y56
V
D
F
Q
N
T
P
Y
C
F
D
Q
L
R
R
Site 3
S70
R
R
F
G
D
V
F
S
L
Q
L
A
W
T
P
Site 4
T93
A
V
R
E
A
L
V
T
H
G
E
D
T
A
D
Site 5
T107
D
R
P
P
V
P
I
T
Q
I
L
G
F
G
P
Site 6
Y124
Q
G
V
F
L
A
R
Y
G
P
A
W
R
E
Q
Site 7
S135
W
R
E
Q
R
R
F
S
V
S
T
L
R
N
L
Site 8
S137
E
Q
R
R
F
S
V
S
T
L
R
N
L
G
L
Site 9
T138
Q
R
R
F
S
V
S
T
L
R
N
L
G
L
G
Site 10
S148
N
L
G
L
G
K
K
S
L
E
Q
W
V
T
E
Site 11
T154
K
S
L
E
Q
W
V
T
E
E
A
A
C
L
C
Site 12
S168
C
A
A
F
A
N
H
S
G
R
P
F
R
P
N
Site 13
T190
S
N
V
I
A
S
L
T
C
G
R
R
F
E
Y
Site 14
Y197
T
C
G
R
R
F
E
Y
D
D
P
R
F
L
R
Site 15
S217
Q
E
G
L
K
E
E
S
G
F
L
R
E
V
L
Site 16
T249
R
F
Q
K
A
F
L
T
Q
L
D
E
L
L
T
Site 17
T256
T
Q
L
D
E
L
L
T
E
H
R
M
T
W
D
Site 18
T261
L
L
T
E
H
R
M
T
W
D
P
A
Q
P
P
Site 19
T272
A
Q
P
P
R
D
L
T
E
A
F
L
A
E
M
Site 20
S289
A
K
G
N
P
E
S
S
F
N
D
E
N
L
R
Site 21
S379
L
G
V
T
H
M
T
S
R
D
I
E
V
Q
G
Site 22
S465
T
S
L
L
Q
H
F
S
F
S
V
P
T
G
Q
Site 23
S467
L
L
Q
H
F
S
F
S
V
P
T
G
Q
P
R
Site 24
T470
H
F
S
F
S
V
P
T
G
Q
P
R
P
S
H
Site 25
S476
P
T
G
Q
P
R
P
S
H
H
G
V
F
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation