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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
tau
Full Name:
Microtubule-associated protein tau
Alias:
DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MAPTL; MGC138549; Microtubule-associated protein tau, isoform 4; MSTD; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; PPND; TAU; Tau
Type:
Cytoskeletal protein
Mass (Da):
78878
Number AA:
758
UniProt ID:
P10636
International Prot ID:
IPI00747283
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
GO:0005829
GO:0030426
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0034187
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0000226
GO:0007026
GO:0045773
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Site 2
T39
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
Site 3
S46
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
Site 4
T50
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
Site 5
T52
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
Site 6
S56
Q
T
P
T
E
D
G
S
E
E
P
G
S
E
T
Site 7
S61
D
G
S
E
E
P
G
S
E
T
S
D
A
K
S
Site 8
S64
E
E
P
G
S
E
T
S
D
A
K
S
T
P
T
Site 9
S68
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
Site 10
T69
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
Site 11
T95
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
Site 12
T111
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
Site 13
S113
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
Site 14
T123
D
E
A
A
G
H
V
T
Q
E
P
E
S
G
K
Site 15
S146
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
Site 16
T167
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
Site 17
S171
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
Site 18
T173
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
Site 19
T178
S
G
T
G
P
E
D
T
E
G
G
R
H
A
P
Site 20
S214
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
Site 21
S227
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
Site 22
S228
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
Site 23
S232
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
Site 24
S235
S
P
Q
D
S
P
P
S
K
A
S
P
A
Q
D
Site 25
S238
D
S
P
P
S
K
A
S
P
A
Q
D
G
R
P
Site 26
T248
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
Site 27
T254
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
Site 28
T277
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
Site 29
S282
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
Site 30
S288
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
Site 31
T302
Q
D
A
P
L
E
F
T
F
H
V
E
I
T
P
Site 32
T308
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
Site 33
S341
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
Site 34
S369
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
Site 35
S380
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
Site 36
S382
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
Site 37
T386
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
Site 38
S388
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
Site 39
T395
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
Site 40
S396
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
Site 41
S400
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
Site 42
T403
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
Site 43
S411
L
K
N
R
P
C
L
S
P
K
L
P
T
P
G
Site 44
T416
C
L
S
P
K
L
P
T
P
G
S
S
D
P
L
Site 45
S419
P
K
L
P
T
P
G
S
S
D
P
L
I
Q
P
Site 46
S420
K
L
P
T
P
G
S
S
D
P
L
I
Q
P
S
Site 47
S427
S
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
Site 48
S428
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
Site 49
S437
A
V
C
P
E
P
P
S
S
P
K
H
V
S
S
Site 50
S438
V
C
P
E
P
P
S
S
P
K
H
V
S
S
V
Site 51
S443
P
S
S
P
K
H
V
S
S
V
T
S
R
T
G
Site 52
S444
S
S
P
K
H
V
S
S
V
T
S
R
T
G
S
Site 53
T446
P
K
H
V
S
S
V
T
S
R
T
G
S
S
G
Site 54
S447
K
H
V
S
S
V
T
S
R
T
G
S
S
G
A
Site 55
S451
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
Site 56
T466
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
Site 57
T470
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
Site 58
T492
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
Site 59
T498
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
Site 60
S501
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
Site 61
S502
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
Site 62
S508
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
Site 63
S512
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
Site 64
Y514
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
Site 65
S515
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
Site 66
S516
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
Site 67
S519
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
Site 68
T522
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
Site 69
S525
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
Site 70
S527
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
Site 71
T529
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
Site 72
S531
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
Site 73
T534
S
R
T
P
S
L
P
T
P
P
T
R
E
P
K
Site 74
T537
P
S
L
P
T
P
P
T
R
E
P
K
K
V
A
Site 75
T548
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
Site 76
S552
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
Site 77
S554
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
Site 78
S555
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
Site 79
S558
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
Site 80
T562
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
Site 81
S575
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
Site 82
S579
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
Site 83
S602
I
N
K
K
L
D
L
S
N
V
Q
S
K
C
G
Site 84
S606
L
D
L
S
N
V
Q
S
K
C
G
S
K
D
N
Site 85
S610
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
Site 86
S622
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
Site 87
Y627
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
Site 88
S633
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
Site 89
T636
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
Site 90
S637
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
Site 91
S641
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
Site 92
S658
G
G
Q
V
E
V
K
S
E
K
L
D
F
K
D
Site 93
S669
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
Site 94
S673
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
Site 95
T678
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
Site 96
T690
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
Site 97
T694
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
Site 98
Y711
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
Site 99
S713
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
Site 100
S717
V
Y
K
S
P
V
V
S
G
D
T
S
P
R
H
Site 101
T720
S
P
V
V
S
G
D
T
S
P
R
H
L
S
N
Site 102
S721
P
V
V
S
G
D
T
S
P
R
H
L
S
N
V
Site 103
S726
D
T
S
P
R
H
L
S
N
V
S
S
T
G
S
Site 104
S729
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
Site 105
S730
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
Site 106
T731
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
Site 107
S733
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Site 108
S739
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
Site 109
T744
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation