KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
C7
Full Name:
Complement component C7
Alias:
Type:
Mass (Da):
93518
Number AA:
843
UniProt ID:
P10643
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
G
F
I
G
E
F
Q
S
F
S
S
A
S
S
P
Site 2
S20
I
G
E
F
Q
S
F
S
S
A
S
S
P
V
N
Site 3
S21
G
E
F
Q
S
F
S
S
A
S
S
P
V
N
C
Site 4
S24
Q
S
F
S
S
A
S
S
P
V
N
C
Q
W
D
Site 5
T45
E
C
N
G
C
T
K
T
Q
T
R
R
R
S
V
Site 6
T47
N
G
C
T
K
T
Q
T
R
R
R
S
V
A
V
Site 7
S51
K
T
Q
T
R
R
R
S
V
A
V
Y
G
Q
Y
Site 8
Y55
R
R
R
S
V
A
V
Y
G
Q
Y
G
G
Q
P
Site 9
S72
G
N
A
F
E
T
Q
S
C
E
P
T
R
G
C
Site 10
S93
G
E
R
F
R
C
F
S
G
Q
C
I
S
K
S
Site 11
S100
S
G
Q
C
I
S
K
S
L
V
C
N
G
D
S
Site 12
S107
S
L
V
C
N
G
D
S
D
C
D
E
D
S
A
Site 13
S113
D
S
D
C
D
E
D
S
A
D
E
D
R
C
E
Site 14
S122
D
E
D
R
C
E
D
S
E
R
R
P
S
C
D
Site 15
S127
E
D
S
E
R
R
P
S
C
D
I
D
K
P
P
Site 16
T140
P
P
P
N
I
E
L
T
G
N
G
Y
N
E
L
Site 17
Y144
I
E
L
T
G
N
G
Y
N
E
L
T
G
Q
F
Site 18
S160
N
R
V
I
N
T
K
S
F
G
G
Q
C
R
K
Site 19
S170
G
Q
C
R
K
V
F
S
G
D
G
K
D
F
Y
Site 20
Y177
S
G
D
G
K
D
F
Y
R
L
S
G
N
V
L
Site 21
S180
G
K
D
F
Y
R
L
S
G
N
V
L
S
Y
T
Site 22
T187
S
G
N
V
L
S
Y
T
F
Q
V
K
I
N
N
Site 23
Y198
K
I
N
N
D
F
N
Y
E
F
Y
N
S
T
W
Site 24
Y207
F
Y
N
S
T
W
S
Y
V
K
H
T
S
T
E
Site 25
S212
W
S
Y
V
K
H
T
S
T
E
H
T
S
S
S
Site 26
T213
S
Y
V
K
H
T
S
T
E
H
T
S
S
S
R
Site 27
T216
K
H
T
S
T
E
H
T
S
S
S
R
K
R
S
Site 28
S217
H
T
S
T
E
H
T
S
S
S
R
K
R
S
F
Site 29
S218
T
S
T
E
H
T
S
S
S
R
K
R
S
F
F
Site 30
S219
S
T
E
H
T
S
S
S
R
K
R
S
F
F
R
Site 31
S223
T
S
S
S
R
K
R
S
F
F
R
S
S
S
S
Site 32
S227
R
K
R
S
F
F
R
S
S
S
S
S
S
R
S
Site 33
S228
K
R
S
F
F
R
S
S
S
S
S
S
R
S
Y
Site 34
S229
R
S
F
F
R
S
S
S
S
S
S
R
S
Y
T
Site 35
S230
S
F
F
R
S
S
S
S
S
S
R
S
Y
T
S
Site 36
S231
F
F
R
S
S
S
S
S
S
R
S
Y
T
S
H
Site 37
S232
F
R
S
S
S
S
S
S
R
S
Y
T
S
H
T
Site 38
S234
S
S
S
S
S
S
R
S
Y
T
S
H
T
N
E
Site 39
Y235
S
S
S
S
S
R
S
Y
T
S
H
T
N
E
I
Site 40
T236
S
S
S
S
R
S
Y
T
S
H
T
N
E
I
H
Site 41
S237
S
S
S
R
S
Y
T
S
H
T
N
E
I
H
K
Site 42
S281
E
P
F
W
K
E
L
S
H
L
P
S
L
Y
D
Site 43
S285
K
E
L
S
H
L
P
S
L
Y
D
Y
S
A
Y
Site 44
Y287
L
S
H
L
P
S
L
Y
D
Y
S
A
Y
R
R
Site 45
Y289
H
L
P
S
L
Y
D
Y
S
A
Y
R
R
L
I
Site 46
S290
L
P
S
L
Y
D
Y
S
A
Y
R
R
L
I
D
Site 47
Y292
S
L
Y
D
Y
S
A
Y
R
R
L
I
D
Q
Y
Site 48
Y299
Y
R
R
L
I
D
Q
Y
G
T
H
Y
L
Q
S
Site 49
Y303
I
D
Q
Y
G
T
H
Y
L
Q
S
G
S
L
G
Site 50
S306
Y
G
T
H
Y
L
Q
S
G
S
L
G
G
E
Y
Site 51
S308
T
H
Y
L
Q
S
G
S
L
G
G
E
Y
R
V
Site 52
Y313
S
G
S
L
G
G
E
Y
R
V
L
F
Y
V
D
Site 53
Y318
G
E
Y
R
V
L
F
Y
V
D
S
E
K
L
K
Site 54
S321
R
V
L
F
Y
V
D
S
E
K
L
K
Q
N
D
Site 55
S331
L
K
Q
N
D
F
N
S
V
E
E
K
K
C
K
Site 56
Y403
P
A
G
N
K
R
R
Y
S
A
W
A
E
S
V
Site 57
S404
A
G
N
K
R
R
Y
S
A
W
A
E
S
V
T
Site 58
S409
R
Y
S
A
W
A
E
S
V
T
N
L
P
Q
V
Site 59
T411
S
A
W
A
E
S
V
T
N
L
P
Q
V
I
K
Site 60
T422
Q
V
I
K
Q
K
L
T
P
L
Y
E
L
V
K
Site 61
Y425
K
Q
K
L
T
P
L
Y
E
L
V
K
E
V
P
Site 62
Y448
L
K
W
A
L
E
E
Y
L
D
E
F
D
P
C
Site 63
T518
P
C
V
Q
G
K
K
T
R
S
R
E
C
N
N
Site 64
S529
E
C
N
N
P
P
P
S
G
G
G
R
S
C
V
Site 65
S534
P
P
S
G
G
G
R
S
C
V
G
E
T
T
E
Site 66
S542
C
V
G
E
T
T
E
S
T
Q
C
E
D
E
E
Site 67
S573
V
P
T
E
F
C
P
S
P
P
A
L
K
D
G
Site 68
T587
G
F
V
Q
D
E
G
T
M
F
P
V
G
K
N
Site 69
Y597
P
V
G
K
N
V
V
Y
T
C
N
E
G
Y
S
Site 70
T598
V
G
K
N
V
V
Y
T
C
N
E
G
Y
S
L
Site 71
Y649
S
H
P
Q
K
P
F
Y
T
V
G
E
K
V
T
Site 72
T650
H
P
Q
K
P
F
Y
T
V
G
E
K
V
T
V
Site 73
S660
E
K
V
T
V
S
C
S
G
G
M
S
L
E
G
Site 74
S675
P
S
A
F
L
C
G
S
S
L
K
W
S
P
E
Site 75
S676
S
A
F
L
C
G
S
S
L
K
W
S
P
E
M
Site 76
S680
C
G
S
S
L
K
W
S
P
E
M
K
N
A
R
Site 77
T696
V
Q
K
E
N
P
L
T
Q
A
V
P
K
C
Q
Site 78
Y719
R
C
V
C
K
M
P
Y
E
C
G
P
S
L
D
Site 79
S734
V
C
A
Q
D
E
R
S
K
R
I
L
P
L
T
Site 80
Y755
L
H
C
Q
G
R
N
Y
T
L
T
G
R
D
S
Site 81
T756
H
C
Q
G
R
N
Y
T
L
T
G
R
D
S
C
Site 82
T758
Q
G
R
N
Y
T
L
T
G
R
D
S
C
T
L
Site 83
S762
Y
T
L
T
G
R
D
S
C
T
L
P
A
S
A
Site 84
T764
L
T
G
R
D
S
C
T
L
P
A
S
A
E
K
Site 85
S768
D
S
C
T
L
P
A
S
A
E
K
A
C
G
A
Site 86
S787
G
K
C
D
A
E
S
S
K
C
V
C
R
E
A
Site 87
S795
K
C
V
C
R
E
A
S
E
C
E
E
E
G
F
Site 88
S816
N
G
K
E
Q
T
M
S
E
C
E
A
G
A
L
Site 89
S829
A
L
R
C
R
G
Q
S
I
S
V
T
S
I
R
Site 90
S831
R
C
R
G
Q
S
I
S
V
T
S
I
R
P
C
Site 91
T833
R
G
Q
S
I
S
V
T
S
I
R
P
C
A
A
Site 92
S834
G
Q
S
I
S
V
T
S
I
R
P
C
A
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation