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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THRB
Full Name:
Thyroid hormone receptor beta
Alias:
Avian erythroblastic leukemia viral (v-erb-a) oncogene 2; C-ERBA-BETA; ERBA2; ERBA-BETA; Erythroblastic leukemia viral (v-erb-a) oncogene 2; Generalized resistance to thyroid hormone; GRTH; NR1A2; Oncogene ERBA2; THB; THB1; THR1; THRB1; THRB2; Thyroid hormone receptor beta 1; Thyroid hormone receptor beta-1; Thyroid hormone receptor, beta
Type:
Transcription protein (receptor)
Mass (Da):
52788
Number AA:
461
UniProt ID:
P10828
International Prot ID:
IPI00446999
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003707
GO:0004887
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
S
M
T
E
N
G
L
T
A
W
D
K
P
K
H
Site 2
S41
E
A
C
L
H
R
K
S
H
S
E
R
R
S
T
Site 3
S43
C
L
H
R
K
S
H
S
E
R
R
S
T
L
K
Site 4
S47
K
S
H
S
E
R
R
S
T
L
K
N
E
Q
S
Site 5
T48
S
H
S
E
R
R
S
T
L
K
N
E
Q
S
S
Site 6
S54
S
T
L
K
N
E
Q
S
S
P
H
L
I
Q
T
Site 7
S55
T
L
K
N
E
Q
S
S
P
H
L
I
Q
T
T
Site 8
T61
S
S
P
H
L
I
Q
T
T
W
T
S
S
I
F
Site 9
T62
S
P
H
L
I
Q
T
T
W
T
S
S
I
F
H
Site 10
S79
H
D
D
V
N
D
Q
S
V
S
S
A
Q
T
F
Site 11
T85
Q
S
V
S
S
A
Q
T
F
Q
T
E
E
K
K
Site 12
S99
K
C
K
G
Y
I
P
S
Y
L
D
K
D
E
L
Site 13
Y100
C
K
G
Y
I
P
S
Y
L
D
K
D
E
L
C
Site 14
Y119
D
K
A
T
G
Y
H
Y
R
C
I
T
C
E
G
Site 15
S142
I
Q
K
N
L
H
P
S
Y
S
C
K
Y
E
G
Site 16
Y143
Q
K
N
L
H
P
S
Y
S
C
K
Y
E
G
K
Site 17
Y147
H
P
S
Y
S
C
K
Y
E
G
K
C
V
I
D
Site 18
Y171
C
R
F
K
K
C
I
Y
V
G
M
A
T
D
L
Site 19
S183
T
D
L
V
L
D
D
S
K
R
L
A
K
R
K
Site 20
S207
R
R
E
E
L
Q
K
S
I
G
H
K
P
E
P
Site 21
T224
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
Site 22
Y321
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
Site 23
S325
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
Site 24
T329
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
Site 25
S361
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
Site 26
S362
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
Site 27
Y395
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
Site 28
S398
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Site 29
Y406
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation