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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSPA5
Full Name:
78 kDa glucose-regulated protein
Alias:
BiP; Endoplasmic reticulum lumenal Ca; Glucose-regulated protein; GRP 78; GRP78; Heat shock 70kDa protein 5; Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD); Immunoglobulin heavy chain binding protein; MIF2
Type:
Chaperone protein
Mass (Da):
72333
Number AA:
654
UniProt ID:
P11021
International Prot ID:
IPI00003362
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005793
GO:0009986
GO:0005788
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0043027
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0042149
GO:0043154
Phosida
TranscriptoNet
STRING
Kinexus Products
78 kDa glucose-regulated protein pan-specific antibody AB-NN048-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN048-2#78 kDa glucose-regulated protein pan-specific antibody AB-NN048-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN048-3#78 kDa glucose-regulated protein pan-specific antibody AB-NN048-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN048-4#78 kDa glucose-regulated protein pan-specific antibody AB-NN048-5#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN048-5#78 kDa glucose-regulated protein pan-specific antibody AB-NN048-6#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN048-6#78 kDa glucose-regulated protein pan-specific antibody AB-NN048-7#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN048-7#78 kDa glucose-regulated protein pan-specific antibody AB-NN048-8#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN048-8
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
K
L
S
L
V
A
A
M
L
L
Site 2
S14
A
A
M
L
L
L
L
S
A
A
R
A
E
E
E
Site 3
T29
D
K
K
E
D
V
G
T
V
V
G
I
D
L
G
Site 4
T37
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
Site 5
T62
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
Site 6
S64
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
Site 7
Y65
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
Site 8
T69
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
Site 9
T85
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
Site 10
T102
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Site 11
T139
I
G
G
G
Q
T
K
T
F
A
P
E
E
I
S
Site 12
S146
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
Site 13
Y160
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
Site 14
Y175
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
Site 15
T184
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
Site 16
T189
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
Site 17
T203
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
Site 18
T229
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
Site 19
Y270
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
Site 20
T274
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
Site 21
S300
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
Site 22
S301
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
Site 23
S311
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
F
Site 24
S319
F
Y
E
G
E
D
F
S
E
T
L
T
R
A
K
Site 25
T323
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
Site 26
T338
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
Site 27
S349
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
Site 28
S354
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
Site 29
Y396
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
Site 30
T441
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Site 31
S448
T
V
V
P
T
K
K
S
Q
I
F
S
T
A
S
Site 32
S452
T
K
K
S
Q
I
F
S
T
A
S
D
N
Q
P
Site 33
Y466
P
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
Site 34
T473
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
Site 35
T481
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
Site 36
T485
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
Site 37
T512
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
Site 38
T518
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
Site 39
T534
T
N
D
Q
N
R
L
T
P
E
E
I
E
R
M
Site 40
T561
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
Site 41
S567
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Site 42
Y568
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
Site 43
Y570
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
Site 44
S571
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
Site 45
S587
E
K
L
G
G
K
L
S
S
E
D
K
E
T
M
Site 46
S588
K
L
G
G
K
L
S
S
E
D
K
E
T
M
E
Site 47
T593
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
Site 48
S607
E
K
I
E
W
L
E
S
H
Q
D
A
D
I
E
Site 49
Y635
Q
P
I
I
S
K
L
Y
G
S
A
G
P
P
P
Site 50
S637
I
I
S
K
L
Y
G
S
A
G
P
P
P
T
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation