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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPB41
Full Name:
Protein 4.1
Alias:
4.1R; Band 4.1; EPB4.1; P4.1; Protein 4.1;Band 4.1;P4.1;EPB4.1;4.1R;Protein 4.1;Band 4.1;P4.1;EPB4.1;4.1R;Protein 4.1;Band 4.1;P4.1;EPB4.1;4.1R;Protein 4.1;Band 4.1;P4.1;EPB4.1;4.1R;EPB41 protein
Type:
Cytoskeletal protein
Mass (Da):
97017
Number AA:
864
UniProt ID:
P11171
International Prot ID:
IPI00003921
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005545
GO:0030507
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0030866
GO:0032092
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
T
T
E
K
S
L
V
T
E
A
E
N
Site 2
S14
L
V
T
E
A
E
N
S
Q
H
Q
Q
K
E
E
Site 3
S28
E
G
E
E
A
I
N
S
G
Q
Q
E
P
Q
Q
Site 4
T41
Q
Q
E
E
S
C
Q
T
A
A
E
G
D
N
W
Site 5
T60
L
K
A
S
N
G
D
T
P
T
H
E
D
L
T
Site 6
T62
A
S
N
G
D
T
P
T
H
E
D
L
T
K
N
Site 7
T67
T
P
T
H
E
D
L
T
K
N
K
E
R
T
S
Site 8
S74
T
K
N
K
E
R
T
S
E
S
R
G
L
S
R
Site 9
S76
N
K
E
R
T
S
E
S
R
G
L
S
R
L
F
Site 10
S80
T
S
E
S
R
G
L
S
R
L
F
S
S
F
L
Site 11
S84
R
G
L
S
R
L
F
S
S
F
L
K
R
P
K
Site 12
S85
G
L
S
R
L
F
S
S
F
L
K
R
P
K
S
Site 13
S92
S
F
L
K
R
P
K
S
Q
V
S
E
E
E
G
Site 14
S95
K
R
P
K
S
Q
V
S
E
E
E
G
K
E
V
Site 15
S104
E
E
G
K
E
V
E
S
D
K
E
K
G
E
G
Site 16
S121
K
E
I
E
F
G
T
S
L
D
E
E
I
I
L
Site 17
S144
P
E
L
K
T
D
P
S
L
D
L
H
S
L
S
Site 18
S149
D
P
S
L
D
L
H
S
L
S
S
A
E
T
Q
Site 19
S151
S
L
D
L
H
S
L
S
S
A
E
T
Q
P
A
Site 20
S152
L
D
L
H
S
L
S
S
A
E
T
Q
P
A
Q
Site 21
T155
H
S
L
S
S
A
E
T
Q
P
A
Q
E
E
L
Site 22
S188
K
I
E
V
K
E
E
S
P
Q
S
K
A
E
T
Site 23
S191
V
K
E
E
S
P
Q
S
K
A
E
T
E
L
K
Site 24
T195
S
P
Q
S
K
A
E
T
E
L
K
A
S
Q
K
Site 25
S200
A
E
T
E
L
K
A
S
Q
K
P
I
R
K
H
Site 26
T220
K
V
S
L
L
D
D
T
V
Y
E
C
V
V
E
Site 27
Y222
S
L
L
D
D
T
V
Y
E
C
V
V
E
K
H
Site 28
T263
W
D
N
A
T
S
K
T
W
L
D
S
A
K
E
Site 29
Y289
F
T
F
N
V
K
F
Y
P
P
D
P
A
Q
L
Site 30
T297
P
P
D
P
A
Q
L
T
E
D
I
T
R
Y
Y
Site 31
Y303
L
T
E
D
I
T
R
Y
Y
L
C
L
Q
L
R
Site 32
Y304
T
E
D
I
T
R
Y
Y
L
C
L
Q
L
R
Q
Site 33
Y340
I
Q
S
E
L
G
D
Y
D
P
E
L
H
G
V
Site 34
Y349
P
E
L
H
G
V
D
Y
V
S
D
F
K
L
A
Site 35
S351
L
H
G
V
D
Y
V
S
D
F
K
L
A
P
N
Site 36
S373
K
V
M
E
L
H
K
S
Y
R
S
M
T
P
A
Site 37
Y374
V
M
E
L
H
K
S
Y
R
S
M
T
P
A
Q
Site 38
S376
E
L
H
K
S
Y
R
S
M
T
P
A
Q
A
D
Site 39
T378
H
K
S
Y
R
S
M
T
P
A
Q
A
D
L
E
Site 40
S441
W
P
K
V
L
K
I
S
Y
K
R
S
S
F
F
Site 41
Y442
P
K
V
L
K
I
S
Y
K
R
S
S
F
F
I
Site 42
S445
L
K
I
S
Y
K
R
S
S
F
F
I
K
I
R
Site 43
S446
K
I
S
Y
K
R
S
S
F
F
I
K
I
R
P
Site 44
Y459
R
P
G
E
Q
E
Q
Y
E
S
T
I
G
F
K
Site 45
S461
G
E
Q
E
Q
Y
E
S
T
I
G
F
K
L
P
Site 46
S469
T
I
G
F
K
L
P
S
Y
R
A
A
K
K
L
Site 47
Y470
I
G
F
K
L
P
S
Y
R
A
A
K
K
L
W
Site 48
T485
K
V
C
V
E
H
H
T
F
F
R
L
T
S
T
Site 49
T490
H
H
T
F
F
R
L
T
S
T
D
T
I
P
K
Site 50
S491
H
T
F
F
R
L
T
S
T
D
T
I
P
K
S
Site 51
T494
F
R
L
T
S
T
D
T
I
P
K
S
K
F
L
Site 52
S498
S
T
D
T
I
P
K
S
K
F
L
A
L
G
S
Site 53
S505
S
K
F
L
A
L
G
S
K
F
R
Y
S
G
R
Site 54
Y509
A
L
G
S
K
F
R
Y
S
G
R
T
Q
A
Q
Site 55
S510
L
G
S
K
F
R
Y
S
G
R
T
Q
A
Q
T
Site 56
T513
K
F
R
Y
S
G
R
T
Q
A
Q
T
R
Q
A
Site 57
T517
S
G
R
T
Q
A
Q
T
R
Q
A
S
A
L
I
Site 58
S521
Q
A
Q
T
R
Q
A
S
A
L
I
D
R
P
A
Site 59
T534
P
A
P
H
F
E
R
T
A
S
K
R
A
S
R
Site 60
S536
P
H
F
E
R
T
A
S
K
R
A
S
R
S
L
Site 61
S540
R
T
A
S
K
R
A
S
R
S
L
D
G
A
A
Site 62
S542
A
S
K
R
A
S
R
S
L
D
G
A
A
A
V
Site 63
S551
D
G
A
A
A
V
D
S
A
D
R
S
P
R
P
Site 64
S555
A
V
D
S
A
D
R
S
P
R
P
T
S
A
P
Site 65
T559
A
D
R
S
P
R
P
T
S
A
P
A
I
T
Q
Site 66
S560
D
R
S
P
R
P
T
S
A
P
A
I
T
Q
G
Site 67
T565
P
T
S
A
P
A
I
T
Q
G
Q
V
A
E
G
Site 68
S578
E
G
G
V
L
D
A
S
A
K
K
T
V
V
P
Site 69
T582
L
D
A
S
A
K
K
T
V
V
P
K
A
Q
K
Site 70
T611
E
Q
A
E
P
E
P
T
E
A
W
K
V
E
K
Site 71
T624
E
K
T
H
I
E
V
T
V
P
T
S
N
G
D
Site 72
S628
I
E
V
T
V
P
T
S
N
G
D
Q
T
Q
K
Site 73
T633
P
T
S
N
G
D
Q
T
Q
K
L
A
E
K
T
Site 74
Y660
R
L
D
G
E
N
I
Y
I
R
H
S
N
L
M
Site 75
S664
E
N
I
Y
I
R
H
S
N
L
M
L
E
D
L
Site 76
S674
M
L
E
D
L
D
K
S
Q
E
E
I
K
K
H
Site 77
S684
E
I
K
K
H
H
A
S
I
S
E
L
K
K
N
Site 78
S686
K
K
H
H
A
S
I
S
E
L
K
K
N
F
M
Site 79
S695
L
K
K
N
F
M
E
S
V
P
E
P
R
P
S
Site 80
S702
S
V
P
E
P
R
P
S
E
W
D
K
R
L
S
Site 81
S709
S
E
W
D
K
R
L
S
T
H
S
P
F
R
T
Site 82
T710
E
W
D
K
R
L
S
T
H
S
P
F
R
T
L
Site 83
S712
D
K
R
L
S
T
H
S
P
F
R
T
L
N
I
Site 84
T716
S
T
H
S
P
F
R
T
L
N
I
N
G
Q
I
Site 85
T734
E
G
P
P
L
V
K
T
Q
T
V
T
I
S
D
Site 86
T736
P
P
L
V
K
T
Q
T
V
T
I
S
D
N
A
Site 87
S748
D
N
A
N
A
V
K
S
E
I
P
T
K
D
V
Site 88
Y767
T
E
T
K
T
I
T
Y
E
A
A
Q
T
D
D
Site 89
T772
I
T
Y
E
A
A
Q
T
D
D
N
S
G
D
L
Site 90
S776
A
A
Q
T
D
D
N
S
G
D
L
D
P
G
V
Site 91
S792
L
T
A
Q
T
I
T
S
E
T
P
S
S
T
T
Site 92
T794
A
Q
T
I
T
S
E
T
P
S
S
T
T
T
T
Site 93
S796
T
I
T
S
E
T
P
S
S
T
T
T
T
Q
I
Site 94
S797
I
T
S
E
T
P
S
S
T
T
T
T
Q
I
T
Site 95
T801
T
P
S
S
T
T
T
T
Q
I
T
K
T
V
K
Site 96
T806
T
T
T
Q
I
T
K
T
V
K
G
G
I
S
E
Site 97
S812
K
T
V
K
G
G
I
S
E
T
R
I
E
K
R
Site 98
S849
K
E
Q
H
P
D
M
S
V
T
K
V
V
V
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation