KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
UMPS
Full Name:
Uridine 5'-monophosphate synthase
Alias:
EC 2.4.2.10; EC 4.1.1.23; OMPdecase; OPRtase; Orotate phosphoribosyltransferase; Orotidine 5'- phosphate decarboxylase; PYR5; UMP synthase; Uridine monophosphate synthetase
Type:
Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; Lyase; Transferase; EC 4.1.1.23; EC 2.4.2.10
Mass (Da):
52222
Number AA:
480
UniProt ID:
P11172
International Prot ID:
IPI00003923
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004588
GO:0004590
PhosphoSite+
KinaseNET
Biological Process:
GO:0006207
GO:0006222
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
G
P
L
V
T
G
L
Y
D
V
Q
A
F
K
F
Site 2
Y37
S
G
L
S
S
P
I
Y
I
D
L
R
G
I
V
Site 3
S45
I
D
L
R
G
I
V
S
R
P
R
L
L
S
Q
Site 4
T100
M
L
I
R
R
K
E
T
K
D
Y
G
T
K
R
Site 5
Y103
R
R
K
E
T
K
D
Y
G
T
K
R
L
V
E
Site 6
T105
K
E
T
K
D
Y
G
T
K
R
L
V
E
G
T
Site 7
T112
T
K
R
L
V
E
G
T
I
N
P
G
E
T
C
Site 8
T135
S
G
S
S
V
L
E
T
V
E
V
L
Q
K
E
Site 9
T193
Q
K
K
V
D
A
E
T
V
G
R
V
K
R
F
Site 10
S214
V
A
A
N
H
N
G
S
P
L
S
I
K
E
A
Site 11
S217
N
H
N
G
S
P
L
S
I
K
E
A
P
K
E
Site 12
S226
K
E
A
P
K
E
L
S
F
G
A
R
A
E
L
Site 13
S257
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
Site 14
S335
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
Site 15
S376
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
Site 16
Y382
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
Site 17
T383
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
Site 18
S407
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
Site 19
T416
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
Site 20
Y432
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
Site 21
S434
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
Site 22
S444
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
Site 23
S455
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
Site 24
Y466
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Site 25
Y474
R
K
A
A
W
E
A
Y
L
S
R
L
G
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation