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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHRM1
Full Name:
Muscarinic acetylcholine receptor M1
Alias:
Type:
Mass (Da):
51421
Number AA:
460
UniProt ID:
P11229
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T58
K
V
N
T
E
L
K
T
V
N
N
Y
F
L
L
Site 2
S126
I
S
F
D
R
Y
F
S
V
T
R
P
L
S
Y
Site 3
T128
F
D
R
Y
F
S
V
T
R
P
L
S
Y
R
A
Site 4
S132
F
S
V
T
R
P
L
S
Y
R
A
K
R
T
P
Site 5
T138
L
S
Y
R
A
K
R
T
P
R
R
A
A
L
M
Site 6
Y212
C
T
L
Y
W
R
I
Y
R
E
T
E
N
R
A
Site 7
T215
Y
W
R
I
Y
R
E
T
E
N
R
A
R
E
L
Site 8
S228
E
L
A
A
L
Q
G
S
E
T
P
G
K
G
G
Site 9
T230
A
A
L
Q
G
S
E
T
P
G
K
G
G
G
S
Site 10
S237
T
P
G
K
G
G
G
S
S
S
S
S
E
R
S
Site 11
S238
P
G
K
G
G
G
S
S
S
S
S
E
R
S
Q
Site 12
S239
G
K
G
G
G
S
S
S
S
S
E
R
S
Q
P
Site 13
S240
K
G
G
G
S
S
S
S
S
E
R
S
Q
P
G
Site 14
S241
G
G
G
S
S
S
S
S
E
R
S
Q
P
G
A
Site 15
S244
S
S
S
S
S
E
R
S
Q
P
G
A
E
G
S
Site 16
S251
S
Q
P
G
A
E
G
S
P
E
T
P
P
G
R
Site 17
T254
G
A
E
G
S
P
E
T
P
P
G
R
C
C
R
Site 18
Y272
A
P
R
L
L
Q
A
Y
S
W
K
E
E
E
E
Site 19
S273
P
R
L
L
Q
A
Y
S
W
K
E
E
E
E
E
Site 20
S284
E
E
E
E
D
E
G
S
M
E
S
L
T
S
S
Site 21
S287
E
D
E
G
S
M
E
S
L
T
S
S
E
G
E
Site 22
T289
E
G
S
M
E
S
L
T
S
S
E
G
E
E
P
Site 23
S290
G
S
M
E
S
L
T
S
S
E
G
E
E
P
G
Site 24
S291
S
M
E
S
L
T
S
S
E
G
E
E
P
G
S
Site 25
S298
S
E
G
E
E
P
G
S
E
V
V
I
K
M
P
Site 26
S321
P
T
K
Q
P
P
R
S
S
P
N
T
V
K
R
Site 27
S322
T
K
Q
P
P
R
S
S
P
N
T
V
K
R
P
Site 28
T325
P
P
R
S
S
P
N
T
V
K
R
P
T
K
K
Site 29
T330
P
N
T
V
K
R
P
T
K
K
G
R
D
R
A
Site 30
T354
E
Q
L
A
K
R
K
T
F
S
L
V
K
E
K
Site 31
S356
L
A
K
R
K
T
F
S
L
V
K
E
K
K
A
Site 32
T366
K
E
K
K
A
A
R
T
L
S
A
I
L
L
A
Site 33
S368
K
K
A
A
R
T
L
S
A
I
L
L
A
F
I
Site 34
Y408
E
L
G
Y
W
L
C
Y
V
N
S
T
I
N
P
Site 35
S451
K
I
P
K
R
P
G
S
V
H
R
T
P
S
R
Site 36
T455
R
P
G
S
V
H
R
T
P
S
R
Q
C
_
_
Site 37
S457
G
S
V
H
R
T
P
S
R
Q
C
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation