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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACADM
Full Name:
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Alias:
ACAD1; Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; EC 1.3.99.3; MCAD; MCADH
Type:
Other Amino Acids Metabolism - beta-alanine; Mitochondrial; Oxidoreductase; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.3.99.3
Mass (Da):
46588
Number AA:
421
UniProt ID:
P11310
International Prot ID:
IPI00005040
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0003995
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0006635
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
C
R
V
L
R
S
I
S
R
F
H
W
R
S
Q
Site 2
S38
R
E
P
G
L
G
F
S
F
E
F
T
E
Q
Q
Site 3
T42
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
Site 4
T51
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
Site 5
Y67
I
I
P
V
A
A
E
Y
D
K
T
G
E
Y
P
Site 6
T70
V
A
A
E
Y
D
K
T
G
E
Y
P
V
P
L
Site 7
Y73
E
Y
D
K
T
G
E
Y
P
V
P
L
I
R
R
Site 8
Y145
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
Site 9
T150
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Site 10
Y183
A
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
Site 11
Y201
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
Site 12
S245
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
Site 13
T247
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
Site 14
T300
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
Site 15
Y302
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
Site 16
T308
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
Site 17
S320
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
Site 18
S336
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
Site 19
Y337
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
Site 20
S346
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
Site 21
T351
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
Site 22
Y352
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Site 23
Y353
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
Site 24
T383
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
Site 25
Y385
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
Site 26
Y397
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Site 27
Y400
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation