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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP19A1
Full Name:
Cytochrome P450 19A1
Alias:
ARO; ARO1; Aromatase; CP19A; CPV1; CYAR; CYP19; CYPXIX; Cytochrome P450, family 19, subfamily A, polypeptide 1; EC 1.14.14.1; Estrogen synthetase; P-450AROM
Type:
Lipid Metabolism - androgen and estrogen; Oxidoreductase; EC 1.14.14.1
Mass (Da):
57883
Number AA:
503
UniProt ID:
P11511
International Prot ID:
IPI00465065
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0019898
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006694
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
V
W
N
Y
E
G
T
S
S
I
P
G
P
G
Y
Site 2
Y76
G
I
G
S
A
C
N
Y
Y
N
R
V
Y
G
E
Site 3
Y77
I
G
S
A
C
N
Y
Y
N
R
V
Y
G
E
F
Site 4
S98
G
E
E
T
L
I
I
S
K
S
S
S
M
F
H
Site 5
Y112
H
I
M
K
H
N
H
Y
S
S
R
F
G
S
K
Site 6
S114
M
K
H
N
H
Y
S
S
R
F
G
S
K
L
G
Site 7
S118
H
Y
S
S
R
F
G
S
K
L
G
L
Q
C
I
Site 8
T162
P
G
L
V
R
M
V
T
V
C
A
E
S
L
K
Site 9
T170
V
C
A
E
S
L
K
T
H
L
D
R
L
E
E
Site 10
T179
L
D
R
L
E
E
V
T
N
E
S
G
Y
V
D
Site 11
Y241
F
F
K
I
S
W
L
Y
K
K
Y
E
K
S
V
Site 12
S247
L
Y
K
K
Y
E
K
S
V
K
D
L
K
D
A
Site 13
S267
A
E
K
R
R
R
I
S
T
E
E
K
L
E
E
Site 14
T268
E
K
R
R
R
I
S
T
E
E
K
L
E
E
C
Site 15
T292
A
E
K
R
G
D
L
T
R
E
N
V
N
Q
C
Site 16
Y361
K
V
M
E
N
F
I
Y
E
S
M
R
Y
Q
P
Site 17
Y386
E
D
D
V
I
D
G
Y
P
V
K
K
G
T
N
Site 18
T392
G
Y
P
V
K
K
G
T
N
I
I
L
N
I
G
Site 19
Y424
N
F
A
K
N
V
P
Y
R
Y
F
Q
P
F
G
Site 20
Y426
A
K
N
V
P
Y
R
Y
F
Q
P
F
G
F
G
Site 21
Y441
P
R
G
C
A
G
K
Y
I
A
M
V
M
M
K
Site 22
T462
L
R
R
F
H
V
K
T
L
Q
G
Q
C
V
E
Site 23
S478
I
Q
K
I
H
D
L
S
L
H
P
D
E
T
K
Site 24
T484
L
S
L
H
P
D
E
T
K
N
M
L
E
M
I
Site 25
T493
N
M
L
E
M
I
F
T
P
R
N
S
D
R
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation