PhosphoNET

           
Protein Info 
   
Short Name:  MTHFD1
Full Name:  C-1-tetrahydrofolate synthase, cytoplasmic
Alias:  5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C1TC; C-1-tetrahydrofolate synthase, cytoplasmic; EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3; Formyltetrahydrofolate synthetase; Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; MTHFC; MTHFD
Type:  EC 1.5.1.5; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 6.3.4.3; EC 3.5.4.9; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Oxidoreductase; Hydrolase; Ligase
Mass (Da):  101559
Number AA:  935
UniProt ID:  P11586
International Prot ID:  IPI00218342
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005739     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004329  GO:0004477 PhosphoSite+ KinaseNET
Biological Process:  GO:0009396  GO:0000105  GO:0009086 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T25ARLKNQVTQLKEQVP
Site 2T35KEQVPGFTPRLAILQ
Site 3S49QVGNRDDSNLYINVK
Site 4Y52NRDDSNLYINVKLKA
Site 5T75THIKLPRTTTESEVM
Site 6T76HIKLPRTTTESEVMK
Site 7T77IKLPRTTTESEVMKY
Site 8S79LPRTTTESEVMKYIT
Site 9Y84TESEVMKYITSLNED
Site 10S87EVMKYITSLNEDSTV
Site 11T93TSLNEDSTVHGFLVQ
Site 12S105LVQLPLDSENSINTE
Site 13T128EKDVDGLTSINAGRL
Site 14Y240VIDCGINYVPDDKKP
Site 15Y258KVVGDVAYDEAKERA
Site 16S266DEAKERASFITPVPG
Site 17T269KERASFITPVPGGVG
Site 18S286TVAMLMQSTVESAKR
Site 19S290LMQSTVESAKRFLEK
Site 20Y307PGKWMIQYNNLNLKT
Site 21T314YNNLNLKTPVPSDID
Site 22S318NLKTPVPSDIDISRS
Site 23S323VPSDIDISRSCKPKP
Site 24S325SDIDISRSCKPKPIG
Site 25S342AREIGLLSEEVELYG
Site 26Y348LSEEVELYGETKAKV
Site 27Y371KHRPDGKYVVVTGIT
Site 28T388PLGEGKSTTTIGLVQ
Site 29Y402QALGAHLYQNVFACV
Site 30T417RQPSQGPTFGIKGGA
Site 31S430GAAGGGYSQVIPMEE
Site 32T469ARIFHELTQTDKALF
Site 33T471IFHELTQTDKALFNR
Site 34S490VNGVRRFSDIQIRRL
Site 35T505KRLGIEKTDPTTLTD
Site 36T509IEKTDPTTLTDEEIN
Site 37T511KTDPTTLTDEEINRF
Site 38T527RLDIDPETITWQRVL
Site 39T536TWQRVLDTNDRFLRK
Site 40T545DRFLRKITIGQAPTE
Site 41S578AVLALTTSLEDMRER
Site 42S594GKMVVASSKKGEPVS
Site 43S601SKKGEPVSAEDLGVS
Site 44S736ELVEKGFSNLKKQIE
Site 45T761VAVNAFKTDTESELD
Site 46T763VNAFKTDTESELDLI
Site 47S765AFKTDTESELDLISR
Site 48S771ESELDLISRLSREHG
Site 49S774LDLISRLSREHGAFD
Site 50T786AFDAVKCTHWAEGGK
Site 51S810QRAAQAPSSFQLLYD
Site 52S811RAAQAPSSFQLLYDL
Site 53Y816PSSFQLLYDLKLPVE
Site 54Y852AQHKAEVYTKQGFGN
Site 55S870CMAKTHLSLSHNPEQ
Site 56S872AKTHLSLSHNPEQKG
Site 57T928DIDLDPETEQVNGLF
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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