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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPX
Full Name:
Eosinophil peroxidase
Alias:
Type:
Mass (Da):
81040
Number AA:
715
UniProt ID:
P11678
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
L
A
Q
P
C
E
G
T
D
P
A
S
P
G
A
Site 2
S27
C
E
G
T
D
P
A
S
P
G
A
V
E
T
S
Site 3
Y51
K
L
L
V
D
A
A
Y
N
W
T
Q
K
S
I
Site 4
S57
A
Y
N
W
T
Q
K
S
I
K
Q
R
L
R
S
Site 5
S64
S
I
K
Q
R
L
R
S
G
S
A
S
P
M
D
Site 6
S66
K
Q
R
L
R
S
G
S
A
S
P
M
D
L
L
Site 7
S68
R
L
R
S
G
S
A
S
P
M
D
L
L
S
Y
Site 8
S74
A
S
P
M
D
L
L
S
Y
F
K
Q
P
V
A
Site 9
Y75
S
P
M
D
L
L
S
Y
F
K
Q
P
V
A
A
Site 10
T85
Q
P
V
A
A
T
R
T
V
V
R
A
A
D
Y
Site 11
S109
E
K
L
Q
P
Q
R
S
G
P
F
N
V
T
D
Site 12
S130
L
R
L
L
S
Q
A
S
G
C
A
L
R
D
Q
Site 13
S142
R
D
Q
A
E
R
C
S
D
K
Y
R
T
I
T
Site 14
Y145
A
E
R
C
S
D
K
Y
R
T
I
T
G
R
C
Site 15
T149
S
D
K
Y
R
T
I
T
G
R
C
N
N
K
R
Site 16
S180
A
E
Y
E
D
G
L
S
L
P
F
G
W
T
P
Site 17
T186
L
S
L
P
F
G
W
T
P
S
R
R
R
N
G
Site 18
S188
L
P
F
G
W
T
P
S
R
R
R
N
G
F
L
Site 19
T215
R
F
P
N
E
R
L
T
S
D
R
G
R
A
L
Site 20
S216
F
P
N
E
R
L
T
S
D
R
G
R
A
L
M
Site 21
S238
I
D
H
D
L
D
F
S
P
E
S
P
A
R
V
Site 22
S241
D
L
D
F
S
P
E
S
P
A
R
V
A
F
T
Site 23
T256
A
G
V
D
C
E
R
T
C
A
Q
L
P
P
C
Site 24
S290
P
F
F
R
S
A
P
S
C
P
Q
N
K
N
R
Site 25
S317
D
A
S
M
V
Y
G
S
E
V
S
L
S
L
R
Site 26
S320
M
V
Y
G
S
E
V
S
L
S
L
R
L
R
N
Site 27
S322
Y
G
S
E
V
S
L
S
L
R
L
R
N
R
T
Site 28
T329
S
L
R
L
R
N
R
T
N
Y
L
G
L
L
A
Site 29
Y331
R
L
R
N
R
T
N
Y
L
G
L
L
A
I
N
Site 30
T362
H
D
D
P
C
L
L
T
N
R
S
A
R
I
P
Site 31
T376
P
C
F
L
A
G
D
T
R
S
T
E
T
P
K
Site 32
T379
L
A
G
D
T
R
S
T
E
T
P
K
L
A
A
Site 33
T381
G
D
T
R
S
T
E
T
P
K
L
A
A
M
H
Site 34
T389
P
K
L
A
A
M
H
T
L
F
M
R
E
H
N
Site 35
T400
R
E
H
N
R
L
A
T
E
L
R
R
L
N
P
Site 36
Y415
R
W
N
G
D
K
L
Y
N
E
A
R
K
I
M
Site 37
Y431
A
M
V
Q
I
I
T
Y
R
D
F
L
P
L
V
Site 38
T447
G
K
A
R
A
R
R
T
L
G
H
Y
R
G
Y
Site 39
Y451
A
R
R
T
L
G
H
Y
R
G
Y
C
S
N
V
Site 40
Y454
T
L
G
H
Y
R
G
Y
C
S
N
V
D
P
R
Site 41
S486
P
F
M
F
R
L
D
S
Q
Y
R
A
S
A
P
Site 42
Y488
M
F
R
L
D
S
Q
Y
R
A
S
A
P
N
S
Site 43
S491
L
D
S
Q
Y
R
A
S
A
P
N
S
H
V
P
Site 44
S495
Y
R
A
S
A
P
N
S
H
V
P
L
S
S
A
Site 45
S500
P
N
S
H
V
P
L
S
S
A
F
F
A
S
W
Site 46
S501
N
S
H
V
P
L
S
S
A
F
F
A
S
W
R
Site 47
T525
I
L
R
G
L
M
A
T
P
A
K
L
N
R
Q
Site 48
S563
A
A
L
N
M
Q
R
S
R
D
H
G
L
P
G
Site 49
Y571
R
D
H
G
L
P
G
Y
N
A
W
R
R
F
C
Site 50
S581
W
R
R
F
C
G
L
S
Q
P
R
N
L
A
Q
Site 51
S590
P
R
N
L
A
Q
L
S
R
V
L
K
N
Q
D
Site 52
Y606
A
R
K
F
L
N
L
Y
G
T
P
D
N
I
D
Site 53
T608
K
F
L
N
L
Y
G
T
P
D
N
I
D
I
W
Site 54
S667
K
R
Q
R
K
A
L
S
R
I
S
L
S
R
I
Site 55
S670
R
K
A
L
S
R
I
S
L
S
R
I
I
C
D
Site 56
S672
A
L
S
R
I
S
L
S
R
I
I
C
D
N
T
Site 57
T679
S
R
I
I
C
D
N
T
G
I
T
T
V
S
R
Site 58
T683
C
D
N
T
G
I
T
T
V
S
R
D
I
F
R
Site 59
S685
N
T
G
I
T
T
V
S
R
D
I
F
R
A
N
Site 60
Y694
D
I
F
R
A
N
I
Y
P
R
G
F
V
N
C
Site 61
S702
P
R
G
F
V
N
C
S
R
I
P
R
L
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation