|
|
|
|
|
|
|
|
|
|
|
|
Protein Info
|
|
|
|
|
|
Short Name:
|
CDK4
|
|
Full Name:
|
Cell division protein kinase 4
|
|
Alias:
|
CRK3; Cyclin-dependent kinase 4; EC 2.7.11.22; Kinase Cdk4; PSK-J3
|
|
Type:
|
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily
|
|
Mass (Da):
|
33730
|
|
Number AA:
|
303
|
|
UniProt ID:
|
P11802
|
|
International Prot ID:
|
IPI00007811
|
|
Sequence:
|
Retrieve full protein sequence
|
|
|
|
|
GO Terms
|
|
External Links
|
Internal Links
|
|
|
|
|
|
Cellular Component:
|
GO:0000307
GO:0005829
|
Uniprot
|
OncoNet
|
|
Molecular Function:
|
GO:0005524
GO:0004693
GO:0005515
|
PhosphoSite+
|
KinaseNET
|
|
|
Biological Process:
|
GO:0000082
GO:0051301
GO:0048146
|
Phosida
|
TranscriptoNet
|
|
|
|
|
STRING
|
Kinexus Products
Cyclin-dependent protein-serine kinase 4 T172 phosphosite-specific antibody AB-PK569#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK569#RNA polymerase II-CT KinSub - heptapeptide repeat from C-terminus peptide; CDKtide protein kinase substrate peptide - Powder PE-01ADN95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADN95#CDK4/6Selectide - CDK4 protein kinase substrate peptide - Powder PE-01BGP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BGP99#Cyclin-dependent protein-serine kinase 4 (M169-V175, human) pT172 phosphopeptide - Powder PE-04AJN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AJN99
|
|
|
|
|
Info Box
|
|
A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
|
| Phosphosites | |
| |
| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| | Site 1 | Y17 | A | E | I | G | V | G | A | Y | G | T | V | Y | K | A | R | |  | | |  | | |  | | | |
| | Site 2 | T19 | I | G | V | G | A | Y | G | T | V | Y | K | A | R | D | P | |  | | | | | | | | | |
| | Site 3 | Y21 | V | G | A | Y | G | T | V | Y | K | A | R | D | P | H | S | | | | | | | | | | | |
| | Site 4 | S28 | Y | K | A | R | D | P | H | S | G | H | F | V | A | L | K | | | | | | | | | | | |
| | Site 5 | S81 | L | M | D | V | C | A | T | S | R | T | D | R | E | I | K | | | | | | | | | | | |
| | Site 6 | T90 | T | D | R | E | I | K | V | T | L | V | F | E | H | V | D | | | | | | | | | | | |
| | Site 7 | Y103 | V | D | Q | D | L | R | T | Y | L | D | K | A | P | P | P | | | | | | | | | | | |
| | Site 8 | S150 | P | E | N | I | L | V | T | S | G | G | T | V | K | L | A | | | | | | | | | | | |
| | Site 9 | T172 | Y | S | Y | Q | M | A | L | T | P | V | V | V | T | L | W | | | | | |  Cyclin-dependent protein-serine kinase 4 T172 phosphosite-specific antibody AB-PK569#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK569#Cyclin-dependent protein-serine kinase 4 (M169-V175, human) pT172 phosphopeptide - Powder PE-04AJN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AJN99 | | | | | |
| | Site 10 | S218 | K | P | L | F | C | G | N | S | E | A | D | Q | L | G | K | | | | | | | | | | | |
| | Site 11 | S243 | D | D | W | P | R | D | V | S | L | P | R | G | A | F | P | | | | | | | | | | | |
| | Site 12 | S259 | R | G | P | R | P | V | Q | S | V | V | P | E | M | E | E | | | | | | | | | | | |
| | Site 13 | T277 | Q | L | L | L | E | M | L | T | F | N | P | H | K | R | I | | | | | | | | | | | |
| | Site 14 | S285 | F | N | P | H | K | R | I | S | A | F | R | A | L | Q | H | | | | | | | | | | | |
| | Site 15 | S293 | A | F | R | A | L | Q | H | S | Y | L | H | K | D | E | G | | | | | | | | | | | |
|
|
|
|
|
|
|
|
Legend
|
|
|
|
Confirmed in mammals
|
|
Confirmed in related proteins or other species
|
|
|
Predicted by Kinexus P-Site Prediction algorithm
|
|
|
No data/link available
|
|
|
Link available
|
|
|
Products available
|
|
|
|
|
|
|