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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PABPC1
Full Name:
Polyadenylate-binding protein 1
Alias:
PAB1; PABP1; PABPC2; PABPL1; Poly (A) binding protein, cytoplasmic 1; Poly(A)-binding protein 1
Type:
RNA binding protein
Mass (Da):
70671
Number AA:
636
UniProt ID:
P11940
International Prot ID:
IPI00008524
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005681
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0008143
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006378
GO:0048255
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
N
P
S
A
P
S
Y
P
M
A
S
L
Y
Site 2
Y8
M
N
P
S
A
P
S
Y
P
M
A
S
L
Y
V
Site 3
Y14
S
Y
P
M
A
S
L
Y
V
G
D
L
H
P
D
Site 4
T23
G
D
L
H
P
D
V
T
E
A
M
L
Y
E
K
Site 5
Y28
D
V
T
E
A
M
L
Y
E
K
F
S
P
A
G
Site 6
S32
A
M
L
Y
E
K
F
S
P
A
G
P
I
L
S
Site 7
T48
R
V
C
R
D
M
I
T
R
R
S
L
G
Y
A
Site 8
S51
R
D
M
I
T
R
R
S
L
G
Y
A
Y
V
N
Site 9
Y54
I
T
R
R
S
L
G
Y
A
Y
V
N
F
Q
Q
Site 10
Y56
R
R
S
L
G
Y
A
Y
V
N
F
Q
Q
P
A
Site 11
T71
D
A
E
R
A
L
D
T
M
N
F
D
V
I
K
Site 12
S87
K
P
V
R
I
M
W
S
Q
R
D
P
S
L
R
Site 13
S92
M
W
S
Q
R
D
P
S
L
R
K
S
G
V
G
Site 14
S96
R
D
P
S
L
R
K
S
G
V
G
N
I
F
I
Site 15
S109
F
I
K
N
L
D
K
S
I
D
N
K
A
L
Y
Site 16
Y116
S
I
D
N
K
A
L
Y
D
T
F
S
A
F
G
Site 17
T118
D
N
K
A
L
Y
D
T
F
S
A
F
G
N
I
Site 18
S175
V
F
V
G
R
F
K
S
R
K
E
R
E
A
E
Site 19
T191
G
A
R
A
K
E
F
T
N
V
Y
I
K
N
F
Site 20
Y194
A
K
E
F
T
N
V
Y
I
K
N
F
G
E
D
Site 21
S219
G
K
F
G
P
A
L
S
V
K
V
M
T
D
E
Site 22
S227
V
K
V
M
T
D
E
S
G
K
S
K
G
F
G
Site 23
S230
M
T
D
E
S
G
K
S
K
G
F
G
F
V
S
Site 24
S237
S
K
G
F
G
F
V
S
F
E
R
H
E
D
A
Site 25
Y262
E
L
N
G
K
Q
I
Y
V
G
R
A
Q
K
K
Site 26
T274
Q
K
K
V
E
R
Q
T
E
L
K
R
K
F
E
Site 27
T289
Q
M
K
Q
D
R
I
T
R
Y
Q
G
V
N
L
Site 28
Y291
K
Q
D
R
I
T
R
Y
Q
G
V
N
L
Y
V
Site 29
Y297
R
Y
Q
G
V
N
L
Y
V
K
N
L
D
D
G
Site 30
S315
E
R
L
R
K
E
F
S
P
F
G
T
I
T
S
Site 31
T319
K
E
F
S
P
F
G
T
I
T
S
A
K
V
M
Site 32
S341
G
F
G
F
V
C
F
S
S
P
E
E
A
T
K
Site 33
S342
F
G
F
V
C
F
S
S
P
E
E
A
T
K
A
Site 34
T360
M
N
G
R
I
V
A
T
K
P
L
Y
V
A
L
Site 35
Y364
I
V
A
T
K
P
L
Y
V
A
L
A
Q
R
K
Site 36
Y382
Q
A
H
L
T
N
Q
Y
M
Q
R
M
A
S
V
Site 37
S388
Q
Y
M
Q
R
M
A
S
V
R
A
V
P
N
P
Site 38
Y400
P
N
P
V
I
N
P
Y
Q
P
A
P
P
S
G
Site 39
S406
P
Y
Q
P
A
P
P
S
G
Y
F
M
A
A
I
Site 40
Y422
Q
T
Q
N
R
A
A
Y
Y
P
P
S
Q
I
A
Site 41
Y423
T
Q
N
R
A
A
Y
Y
P
P
S
Q
I
A
Q
Site 42
S426
R
A
A
Y
Y
P
P
S
Q
I
A
Q
L
R
P
Site 43
S434
Q
I
A
Q
L
R
P
S
P
R
W
T
A
Q
G
Site 44
T438
L
R
P
S
P
R
W
T
A
Q
G
A
R
P
H
Site 45
S464
A
A
P
R
P
P
F
S
T
M
R
P
A
S
S
Site 46
T465
A
P
R
P
P
F
S
T
M
R
P
A
S
S
Q
Site 47
S470
F
S
T
M
R
P
A
S
S
Q
V
P
R
V
M
Site 48
S471
S
T
M
R
P
A
S
S
Q
V
P
R
V
M
S
Site 49
S478
S
Q
V
P
R
V
M
S
T
Q
R
V
A
N
T
Site 50
T479
Q
V
P
R
V
M
S
T
Q
R
V
A
N
T
S
Site 51
S486
T
Q
R
V
A
N
T
S
T
Q
T
M
G
P
R
Site 52
T502
A
A
A
A
A
A
A
T
P
A
V
R
T
V
P
Site 53
Y511
A
V
R
T
V
P
Q
Y
K
Y
A
A
G
V
R
Site 54
Y513
R
T
V
P
Q
Y
K
Y
A
A
G
V
R
N
P
Site 55
S548
G
Q
E
P
L
T
A
S
M
L
A
S
A
P
P
Site 56
S552
L
T
A
S
M
L
A
S
A
P
P
Q
E
Q
K
Site 57
S591
M
L
L
E
I
D
N
S
E
L
L
H
M
L
E
Site 58
S599
E
L
L
H
M
L
E
S
P
E
S
L
R
S
K
Site 59
S602
H
M
L
E
S
P
E
S
L
R
S
K
V
D
E
Site 60
S605
E
S
P
E
S
L
R
S
K
V
D
E
A
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation