PhosphoNET

           
Protein Info 
   
Short Name:  K3
Full Name:  Keratin, type II cytoskeletal 3
Alias:  CK3; CK-3; Cytokeratin 3; K2C3; Keratin 3; KRT2A; KRT3
Type:  Cytoskeletal protein, intermediate filament protein
Mass (Da):  64504
Number AA:  629
UniProt ID:  P12035
International Prot ID:  IPI00290857
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0045095     Uniprot OncoNet
Molecular Function:  GO:0005198     PhosphoSite+ KinaseNET
Biological Process:  GO:0030855  GO:0045104   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MSRQASKTSGGGS
Site 2T8MSRQASKTSGGGSQG
Site 3S9SRQASKTSGGGSQGF
Site 4S13SKTSGGGSQGFSGRS
Site 5S17GGGSQGFSGRSAVVS
Site 6S20SQGFSGRSAVVSGSS
Site 7S24SGRSAVVSGSSRMSC
Site 8S30VSGSSRMSCVAHSGG
Site 9Y43GGAGGGAYGFRSGAG
Site 10S47GGAYGFRSGAGGFGS
Site 11S54SGAGGFGSRSLYNLG
Site 12S56AGGFGSRSLYNLGGN
Site 13Y58GFGSRSLYNLGGNKS
Site 14S69GNKSISISVAAGGSR
Site 15S86GFGGGRSSCAFAGGY
Site 16S99GYGGGFGSGYGGGFG
Site 17Y101GGGFGSGYGGGFGGG
Site 18S146GPGGFGGSGGFGGPG
Site 19S154GGFGGPGSLGSPGGF
Site 20S157GGPGSLGSPGGFGPG
Site 21T174PGGIQEVTINQSLLQ
Site 22T204QEREQIKTLNNKFAS
Site 23S211TLNNKFASFIDKVRF
Site 24T238NLLQQQGTSSISGTN
Site 25S240LQQQGTSSISGTNNL
Site 26S242QQGTSSISGTNNLEP
Site 27T244GTSSISGTNNLEPLF
Site 28Y257LFENHINYLRSYLDN
Site 29Y261HINYLRSYLDNILGE
Site 30S274GERGRLDSELKNMED
Site 31Y290VEDFKKKYEDEINKR
Site 32S313TLKKDVDSAYMNKVE
Site 33Y315KKDVDSAYMNKVELQ
Site 34Y339IDFLRTLYDAELSQM
Site 35S344TLYDAELSQMQSHIS
Site 36S348AELSQMQSHISDTSV
Site 37S351SQMQSHISDTSVVLS
Site 38T353MQSHISDTSVVLSMD
Site 39S354QSHISDTSVVLSMDN
Site 40S358SDTSVVLSMDNNRSL
Site 41S364LSMDNNRSLDLDSII
Site 42S369NRSLDLDSIIAEVRA
Site 43Y378IAEVRAQYEDIAQRS
Site 44Y393KAEAEALYQTKLGEL
Site 45T395EAEALYQTKLGELQT
Site 46T402TKLGELQTTAGRHGD
Site 47T403KLGELQTTAGRHGDD
Site 48T414HGDDLRNTKSEIIEL
Site 49S416DDLRNTKSEIIELNR
Site 50Y485LARLLRDYQELMNVK
Site 51Y502LDVEIATYRKLLEGE
Site 52Y511KLLEGEEYSRMSGEC
Site 53S515GEEYSRMSGECPSAV
Site 54T532SVVSSSTTSASAGGY
Site 55S533VVSSSTTSASAGGYG
Site 56S535SSSTTSASAGGYGGG
Site 57Y539TSASAGGYGGGYGGG
Site 58Y543AGGYGGGYGGGMGGG
Site 59S556GGLGGGFSAGGGSGS
Site 60S561GFSAGGGSGSGFGRG
Site 61S563SAGGGSGSGFGRGGG
Site 62S581GGGFGGGSSGFSGGS
Site 63S582GGFGGGSSGFSGGSG
Site 64S585GGGSSGFSGGSGFGS
Site 65S588SSGFSGGSGFGSISG
Site 66S592SGGSGFGSISGARYG
Site 67S594GSGFGSISGARYGVS
Site 68Y598GSISGARYGVSGGGF
Site 69S601SGARYGVSGGGFSSA
Site 70S606GVSGGGFSSASNRGG
Site 71S607VSGGGFSSASNRGGS
Site 72S609GGGFSSASNRGGSIK
Site 73S614SASNRGGSIKFSQSS
Site 74S618RGGSIKFSQSSQSSQ
Site 75S620GSIKFSQSSQSSQRY
Site 76S621SIKFSQSSQSSQRYS
Site 77S623KFSQSSQSSQRYSR_
Site 78S624FSQSSQSSQRYSR__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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