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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEFH
Full Name:
Neurofilament heavy polypeptide
Alias:
200 kDa neurofilament protein; Neurofilament triplet H protein; Neurofilament, heavy polypeptide; NF-H
Type:
Cytoskeletal protein
Mass (Da):
112479
Number AA:
1026
UniProt ID:
P12036
International Prot ID:
IPI00021751
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
GO:0005883
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
A
P
L
H
G
G
G
S
L
H
Y
A
L
A
R
Site 2
Y26
H
G
G
G
S
L
H
Y
A
L
A
R
K
G
G
Site 3
S39
G
G
A
G
G
T
R
S
A
A
G
S
S
S
G
Site 4
S43
G
T
R
S
A
A
G
S
S
S
G
F
H
S
W
Site 5
S45
R
S
A
A
G
S
S
S
G
F
H
S
W
T
R
Site 6
S49
G
S
S
S
G
F
H
S
W
T
R
T
S
V
S
Site 7
T51
S
S
G
F
H
S
W
T
R
T
S
V
S
S
V
Site 8
T53
G
F
H
S
W
T
R
T
S
V
S
S
V
S
A
Site 9
S54
F
H
S
W
T
R
T
S
V
S
S
V
S
A
S
Site 10
S56
S
W
T
R
T
S
V
S
S
V
S
A
S
P
S
Site 11
S57
W
T
R
T
S
V
S
S
V
S
A
S
P
S
R
Site 12
S59
R
T
S
V
S
S
V
S
A
S
P
S
R
F
R
Site 13
S61
S
V
S
S
V
S
A
S
P
S
R
F
R
G
A
Site 14
S63
S
S
V
S
A
S
P
S
R
F
R
G
A
G
A
Site 15
S72
F
R
G
A
G
A
A
S
S
T
D
S
L
D
T
Site 16
S73
R
G
A
G
A
A
S
S
T
D
S
L
D
T
L
Site 17
T74
G
A
G
A
A
S
S
T
D
S
L
D
T
L
S
Site 18
S76
G
A
A
S
S
T
D
S
L
D
T
L
S
N
G
Site 19
T79
S
S
T
D
S
L
D
T
L
S
N
G
P
E
G
Site 20
S81
T
D
S
L
D
T
L
S
N
G
P
E
G
C
M
Site 21
Y111
L
N
D
R
F
A
G
Y
I
D
K
V
R
Q
L
Site 22
S124
Q
L
E
A
H
N
R
S
L
E
G
E
A
A
A
Site 23
Y146
R
S
A
M
G
E
L
Y
E
R
E
V
R
E
M
Site 24
Y229
A
L
Q
E
E
C
G
Y
L
R
R
H
H
Q
E
Site 25
T268
D
A
L
K
C
D
V
T
S
A
L
R
E
I
R
Site 26
T286
E
G
H
A
V
Q
S
T
L
Q
S
E
E
W
F
Site 27
S289
A
V
Q
S
T
L
Q
S
E
E
W
F
R
V
R
Site 28
S301
R
V
R
L
D
R
L
S
E
A
A
K
V
N
T
Site 29
Y321
A
Q
E
E
I
T
E
Y
R
R
Q
L
Q
A
R
Site 30
T330
R
Q
L
Q
A
R
T
T
E
L
E
A
L
K
S
Site 31
S337
T
E
L
E
A
L
K
S
T
K
D
S
L
E
R
Site 32
S341
A
L
K
S
T
K
D
S
L
E
R
Q
R
S
E
Site 33
S347
D
S
L
E
R
Q
R
S
E
L
E
D
R
H
Q
Site 34
T374
L
D
A
E
L
R
N
T
K
W
E
M
A
A
Q
Site 35
Y385
M
A
A
Q
L
R
E
Y
Q
D
L
L
N
V
K
Site 36
Y402
L
D
I
E
I
A
A
Y
R
K
L
L
E
G
E
Site 37
S421
G
F
G
P
I
P
F
S
L
P
E
G
L
P
K
Site 38
S431
E
G
L
P
K
I
P
S
V
S
T
H
I
K
V
Site 39
S433
L
P
K
I
P
S
V
S
T
H
I
K
V
K
S
Site 40
T434
P
K
I
P
S
V
S
T
H
I
K
V
K
S
E
Site 41
S440
S
T
H
I
K
V
K
S
E
E
K
I
K
V
V
Site 42
S450
K
I
K
V
V
E
K
S
E
K
E
T
V
I
V
Site 43
T454
V
E
K
S
E
K
E
T
V
I
V
E
E
Q
T
Site 44
T467
Q
T
E
E
T
Q
V
T
E
E
V
T
E
E
E
Site 45
T501
A
E
G
G
E
E
E
T
K
S
P
P
A
E
E
Site 46
S503
G
G
E
E
E
T
K
S
P
P
A
E
E
A
A
Site 47
S511
P
P
A
E
E
A
A
S
P
E
K
E
A
K
S
Site 48
S518
S
P
E
K
E
A
K
S
P
V
K
E
E
A
K
Site 49
S526
P
V
K
E
E
A
K
S
P
A
E
A
K
S
P
Site 50
S532
K
S
P
A
E
A
K
S
P
E
K
E
E
A
K
Site 51
S540
P
E
K
E
E
A
K
S
P
A
E
V
K
S
P
Site 52
S546
K
S
P
A
E
V
K
S
P
E
K
A
K
S
P
Site 53
S552
K
S
P
E
K
A
K
S
P
A
K
E
E
A
K
Site 54
S560
P
A
K
E
E
A
K
S
P
P
E
A
K
S
P
Site 55
S566
K
S
P
P
E
A
K
S
P
E
K
E
E
A
K
Site 56
S594
P
A
K
E
E
A
K
S
P
A
E
A
K
S
P
Site 57
S600
K
S
P
A
E
A
K
S
P
E
K
A
K
S
P
Site 58
S606
K
S
P
E
K
A
K
S
P
V
K
E
E
A
K
Site 59
S620
K
S
P
A
E
A
K
S
P
V
K
E
E
A
K
Site 60
S628
P
V
K
E
E
A
K
S
P
A
E
V
K
S
P
Site 61
S640
K
S
P
E
K
A
K
S
P
T
K
E
E
A
K
Site 62
S648
P
T
K
E
E
A
K
S
P
E
K
A
K
S
P
Site 63
S654
K
S
P
E
K
A
K
S
P
E
K
A
K
S
P
Site 64
S660
K
S
P
E
K
A
K
S
P
E
K
E
E
A
K
Site 65
S668
P
E
K
E
E
A
K
S
P
E
K
A
K
S
P
Site 66
S674
K
S
P
E
K
A
K
S
P
V
K
A
E
A
K
Site 67
S682
P
V
K
A
E
A
K
S
P
E
K
A
K
S
P
Site 68
S710
P
V
K
E
E
A
K
S
P
E
K
A
K
S
P
Site 69
T738
P
V
K
E
E
A
K
T
P
E
K
A
K
S
P
Site 70
S744
K
T
P
E
K
A
K
S
P
V
K
E
E
A
K
Site 71
S758
K
S
P
E
K
A
K
S
P
E
K
A
K
T
L
Site 72
T764
K
S
P
E
K
A
K
T
L
D
V
K
S
P
E
Site 73
S769
A
K
T
L
D
V
K
S
P
E
A
K
T
P
A
Site 74
T774
V
K
S
P
E
A
K
T
P
A
K
E
E
A
R
Site 75
S782
P
A
K
E
E
A
R
S
P
A
D
K
F
P
E
Site 76
S793
K
F
P
E
K
A
K
S
P
V
K
E
E
V
K
Site 77
S801
P
V
K
E
E
V
K
S
P
E
K
A
K
S
P
Site 78
S807
K
S
P
E
K
A
K
S
P
L
K
E
D
A
K
Site 79
S828
P
K
K
E
E
V
K
S
P
V
K
E
E
E
K
Site 80
T856
E
E
E
K
A
P
A
T
P
K
T
E
E
K
K
Site 81
T859
K
A
P
A
T
P
K
T
E
E
K
K
D
S
K
Site 82
S865
K
T
E
E
K
K
D
S
K
K
E
E
A
P
K
Site 83
T911
E
D
K
K
K
V
P
T
P
E
K
E
A
P
A
Site 84
S948
D
A
K
A
K
E
P
S
K
P
A
E
K
K
E
Site 85
T963
A
A
P
E
K
K
D
T
K
E
E
K
A
K
K
Site 86
T977
K
P
E
E
K
P
K
T
E
A
K
A
K
E
D
Site 87
T987
K
A
K
E
D
D
K
T
L
S
K
E
P
S
K
Site 88
S989
K
E
D
D
K
T
L
S
K
E
P
S
K
P
K
Site 89
S993
K
T
L
S
K
E
P
S
K
P
K
A
E
K
A
Site 90
S1003
K
A
E
K
A
E
K
S
S
S
T
D
Q
K
D
Site 91
S1005
E
K
A
E
K
S
S
S
T
D
Q
K
D
S
K
Site 92
S1011
S
S
T
D
Q
K
D
S
K
P
P
E
K
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation