KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HARS
Full Name:
Histidyl-tRNA synthetase, cytoplasmic
Alias:
EC 6.1.1.21; HisRS; Histidine translase; Histidine tRNA ligase 1, cytoplasmic; Histidine-tRNA ligase; Histidyl-tRNA synthetase; HRS; SYHC
Type:
Enzyme, ligase, class-II aminoacyl-tRNA synthetase
Mass (Da):
57411
Number AA:
509
UniProt ID:
P12081
International Prot ID:
IPI00021808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004821
PhosphoSite+
KinaseNET
Biological Process:
GO:0006427
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S50
A
Q
L
G
P
D
E
S
K
Q
K
F
V
L
K
Site 2
T58
K
Q
K
F
V
L
K
T
P
K
G
T
R
D
Y
Site 3
Y65
T
P
K
G
T
R
D
Y
S
P
R
Q
M
A
V
Site 4
S66
P
K
G
T
R
D
Y
S
P
R
Q
M
A
V
R
Site 5
T94
H
G
A
E
V
I
D
T
P
V
F
E
L
K
E
Site 6
T102
P
V
F
E
L
K
E
T
L
M
G
K
Y
G
E
Site 7
Y107
K
E
T
L
M
G
K
Y
G
E
D
S
K
L
I
Site 8
Y115
G
E
D
S
K
L
I
Y
D
L
K
D
Q
G
G
Site 9
S126
D
Q
G
G
E
L
L
S
L
R
Y
D
L
T
V
Site 10
Y138
L
T
V
P
F
A
R
Y
L
A
M
N
K
L
T
Site 11
Y150
K
L
T
N
I
K
R
Y
H
I
A
K
V
Y
R
Site 12
Y156
R
Y
H
I
A
K
V
Y
R
R
D
N
P
A
M
Site 13
Y168
P
A
M
T
R
G
R
Y
R
E
F
Y
Q
C
D
Site 14
Y172
R
G
R
Y
R
E
F
Y
Q
C
D
F
D
I
A
Site 15
T233
V
S
D
S
K
F
R
T
I
C
S
S
V
D
K
Site 16
S236
S
K
F
R
T
I
C
S
S
V
D
K
L
D
K
Site 17
S237
K
F
R
T
I
C
S
S
V
D
K
L
D
K
V
Site 18
S245
V
D
K
L
D
K
V
S
W
E
E
V
K
N
E
Site 19
Y270
V
A
D
R
I
G
D
Y
V
Q
Q
H
G
G
V
Site 20
S290
L
L
Q
D
P
K
L
S
Q
N
K
Q
A
L
E
Site 21
S323
D
K
I
S
F
D
L
S
L
A
R
G
L
D
Y
Site 22
Y330
S
L
A
R
G
L
D
Y
Y
T
G
V
I
Y
E
Site 23
T343
Y
E
A
V
L
L
Q
T
P
A
Q
A
G
E
E
Site 24
S356
E
E
P
L
G
V
G
S
V
A
A
G
G
R
Y
Site 25
Y363
S
V
A
A
G
G
R
Y
D
G
L
V
G
M
F
Site 26
T406
A
L
E
E
K
I
R
T
T
E
T
Q
V
L
V
Site 27
T407
L
E
E
K
I
R
T
T
E
T
Q
V
L
V
A
Site 28
S429
E
E
R
L
K
L
V
S
E
L
W
D
A
G
I
Site 29
Y454
K
L
L
N
Q
L
Q
Y
C
E
E
A
G
I
P
Site 30
S480
D
G
V
I
K
L
R
S
V
T
S
R
E
E
V
Site 31
T482
V
I
K
L
R
S
V
T
S
R
E
E
V
D
V
Site 32
T502
V
E
E
I
K
R
R
T
G
Q
P
L
C
I
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation