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Updated November 2019
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Protein Info
Short Name:
COL6A3
Full Name:
Collagen alpha-3(VI) chain
Alias:
Type:
Mass (Da):
343665
Number AA:
3177
UniProt ID:
P12111
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
L
F
L
S
G
F
P
T
T
H
A
Q
Q
Q
Q
Site 2
T95
H
T
E
F
L
L
N
T
Y
R
T
K
Q
E
V
Site 3
S104
R
T
K
Q
E
V
L
S
H
I
S
N
M
S
Y
Site 4
Y111
S
H
I
S
N
M
S
Y
I
G
G
T
N
Q
T
Site 5
Y124
Q
T
G
K
G
L
E
Y
I
M
Q
S
H
L
T
Site 6
T150
P
Q
V
I
V
V
L
T
D
G
H
S
K
D
G
Site 7
S162
K
D
G
L
A
L
P
S
A
E
L
K
S
A
D
Site 8
S190
G
A
L
K
E
I
A
S
E
P
L
N
M
H
M
Site 9
S205
F
N
L
E
N
F
T
S
L
H
D
I
V
G
N
Site 10
S219
N
L
V
S
C
V
H
S
S
V
S
P
E
R
A
Site 11
S222
S
C
V
H
S
S
V
S
P
E
R
A
G
D
T
Site 12
T231
E
R
A
G
D
T
E
T
L
K
D
I
T
A
Q
Site 13
T236
T
E
T
L
K
D
I
T
A
Q
D
S
A
D
I
Site 14
S287
R
V
G
V
V
Q
F
S
D
E
P
R
T
M
F
Site 15
T292
Q
F
S
D
E
P
R
T
M
F
S
L
D
T
Y
Site 16
S295
D
E
P
R
T
M
F
S
L
D
T
Y
S
T
K
Site 17
T298
R
T
M
F
S
L
D
T
Y
S
T
K
A
Q
V
Site 18
T335
F
V
V
E
N
H
F
T
R
A
G
G
S
R
V
Site 19
S354
P
Q
V
L
V
L
I
S
A
G
P
S
S
D
E
Site 20
S358
V
L
I
S
A
G
P
S
S
D
E
I
R
Y
G
Site 21
S359
L
I
S
A
G
P
S
S
D
E
I
R
Y
G
V
Site 22
Y364
P
S
S
D
E
I
R
Y
G
V
V
A
L
K
Q
Site 23
T401
T
D
D
N
L
V
F
T
V
P
E
F
R
S
F
Site 24
S407
F
T
V
P
E
F
R
S
F
G
D
L
Q
E
K
Site 25
T433
H
I
V
L
K
P
P
T
I
V
T
Q
V
I
E
Site 26
T492
A
V
A
Q
Y
A
D
T
V
R
P
E
F
Y
F
Site 27
Y498
D
T
V
R
P
E
F
Y
F
N
T
H
P
T
K
Site 28
T510
P
T
K
R
E
V
I
T
A
V
R
K
M
K
P
Site 29
S521
K
M
K
P
L
D
G
S
A
L
Y
T
G
S
A
Site 30
T538
F
V
R
N
N
L
F
T
S
S
A
G
Y
R
A
Site 31
Y543
L
F
T
S
S
A
G
Y
R
A
A
E
G
I
P
Site 32
S561
V
L
I
T
G
G
K
S
L
D
E
I
S
Q
P
Site 33
S566
G
K
S
L
D
E
I
S
Q
P
A
Q
E
L
K
Site 34
S628
L
A
P
L
R
T
L
S
G
T
P
E
V
H
S
Site 35
T630
P
L
R
T
L
S
G
T
P
E
V
H
S
N
K
Site 36
S635
S
G
T
P
E
V
H
S
N
K
R
D
I
I
F
Site 37
T653
G
S
A
N
V
G
K
T
N
F
P
Y
V
R
D
Site 38
Y657
V
G
K
T
N
F
P
Y
V
R
D
F
V
M
N
Site 39
T689
Q
F
S
D
T
P
V
T
E
F
S
L
N
T
Y
Site 40
S692
D
T
P
V
T
E
F
S
L
N
T
Y
Q
T
K
Site 41
Y696
T
E
F
S
L
N
T
Y
Q
T
K
S
D
I
L
Site 42
T698
F
S
L
N
T
Y
Q
T
K
S
D
I
L
G
H
Site 43
S700
L
N
T
Y
Q
T
K
S
D
I
L
G
H
L
R
Site 44
T719
Q
G
G
S
G
L
N
T
G
S
A
L
S
Y
V
Site 45
Y725
N
T
G
S
A
L
S
Y
V
Y
A
N
H
F
T
Site 46
S737
H
F
T
E
A
G
G
S
R
I
R
E
H
V
P
Site 47
S755
L
L
L
T
A
G
Q
S
E
D
S
Y
L
Q
A
Site 48
Y759
A
G
Q
S
E
D
S
Y
L
Q
A
A
N
A
L
Site 49
S804
Y
L
M
D
D
F
S
S
L
P
A
L
P
Q
Q
Site 50
S881
R
I
A
V
A
Q
Y
S
D
D
V
K
V
E
S
Site 51
T910
V
K
R
M
K
I
K
T
G
K
A
L
N
L
G
Site 52
S931
Q
R
Y
I
F
V
K
S
A
G
S
R
I
E
D
Site 53
S952
V
L
L
V
A
G
R
S
S
D
R
V
D
G
P
Site 54
S953
L
L
V
A
G
R
S
S
D
R
V
D
G
P
A
Site 55
S961
D
R
V
D
G
P
A
S
N
L
K
Q
S
G
V
Site 56
S1025
N
G
A
P
A
P
V
S
G
E
K
D
V
V
F
Site 57
S1042
D
G
S
E
G
V
R
S
G
F
P
L
L
K
E
Site 58
Y1072
V
R
V
A
V
V
Q
Y
S
D
R
T
R
P
E
Site 59
S1073
R
V
A
V
V
Q
Y
S
D
R
T
R
P
E
F
Site 60
Y1081
D
R
T
R
P
E
F
Y
L
N
S
Y
M
N
K
Site 61
Y1085
P
E
F
Y
L
N
S
Y
M
N
K
Q
D
V
V
Site 62
T1129
S
S
A
G
S
R
I
T
E
G
V
P
Q
L
L
Site 63
T1140
P
Q
L
L
I
V
L
T
A
D
R
S
G
D
D
Site 64
S1144
I
V
L
T
A
D
R
S
G
D
D
V
R
N
P
Site 65
S1152
G
D
D
V
R
N
P
S
V
V
V
K
R
G
G
Site 66
S1202
G
T
V
Q
Q
V
I
S
E
R
V
T
Q
L
T
Site 67
T1206
Q
V
I
S
E
R
V
T
Q
L
T
R
E
E
L
Site 68
T1209
S
E
R
V
T
Q
L
T
R
E
E
L
S
R
L
Site 69
S1225
P
V
L
Q
P
L
P
S
P
G
V
G
G
K
R
Site 70
S1243
F
L
I
D
G
S
Q
S
A
G
P
E
F
Q
Y
Site 71
Y1250
S
A
G
P
E
F
Q
Y
V
R
T
L
I
E
R
Site 72
S1277
R
V
A
V
I
Q
F
S
D
D
P
K
V
E
F
Site 73
S1290
E
F
L
L
N
A
H
S
S
K
D
E
V
Q
N
Site 74
S1291
F
L
L
N
A
H
S
S
K
D
E
V
Q
N
A
Site 75
Y1318
N
V
G
N
A
L
E
Y
V
S
R
N
I
F
K
Site 76
S1345
Q
F
L
V
L
I
S
S
G
K
S
D
D
E
V
Site 77
S1348
V
L
I
S
S
G
K
S
D
D
E
V
D
D
P
Site 78
T1368
Q
F
G
V
A
P
F
T
I
A
R
N
A
D
Q
Site 79
S1382
Q
E
E
L
V
K
I
S
L
S
P
E
Y
V
F
Site 80
S1392
P
E
Y
V
F
S
V
S
T
F
R
E
L
P
S
Site 81
S1399
S
T
F
R
E
L
P
S
L
E
Q
K
L
L
T
Site 82
T1409
Q
K
L
L
T
P
I
T
T
L
T
S
E
Q
I
Site 83
S1422
Q
I
Q
K
L
L
A
S
T
R
Y
P
P
P
A
Site 84
Y1425
K
L
L
A
S
T
R
Y
P
P
P
A
V
E
S
Site 85
S1443
D
I
V
F
L
I
D
S
S
E
G
V
R
P
D
Site 86
S1471
R
R
L
N
I
G
P
S
K
V
R
V
G
V
V
Site 87
T1492
F
P
E
F
Y
L
K
T
Y
R
S
Q
A
P
V
Site 88
Y1493
P
E
F
Y
L
K
T
Y
R
S
Q
A
P
V
L
Site 89
S1495
F
Y
L
K
T
Y
R
S
Q
A
P
V
L
D
A
Site 90
S1512
R
L
R
L
R
G
G
S
P
L
N
T
G
K
A
Site 91
T1516
R
G
G
S
P
L
N
T
G
K
A
L
E
F
V
Site 92
S1531
A
R
N
L
F
V
K
S
A
G
S
R
I
E
D
Site 93
S1552
V
L
V
L
G
G
K
S
Q
D
D
V
S
R
F
Site 94
S1557
G
K
S
Q
D
D
V
S
R
F
A
Q
V
I
R
Site 95
S1570
I
R
S
S
G
I
V
S
L
G
V
G
D
R
N
Site 96
T1581
G
D
R
N
I
D
R
T
E
L
Q
T
I
T
N
Site 97
T1585
I
D
R
T
E
L
Q
T
I
T
N
D
P
R
L
Site 98
T1587
R
T
E
L
Q
T
I
T
N
D
P
R
L
V
F
Site 99
T1595
N
D
P
R
L
V
F
T
V
R
E
F
R
E
L
Site 100
S1612
I
E
E
R
I
M
N
S
F
G
P
S
A
A
T
Site 101
S1616
I
M
N
S
F
G
P
S
A
A
T
P
A
P
P
Site 102
T1619
S
F
G
P
S
A
A
T
P
A
P
P
G
V
D
Site 103
T1627
P
A
P
P
G
V
D
T
P
P
P
S
R
P
E
Site 104
S1631
G
V
D
T
P
P
P
S
R
P
E
K
K
K
A
Site 105
S1654
S
I
N
F
R
R
D
S
F
Q
E
V
L
R
F
Site 106
T1668
F
V
S
E
I
V
D
T
V
Y
E
D
G
D
S
Site 107
Y1670
S
E
I
V
D
T
V
Y
E
D
G
D
S
I
Q
Site 108
S1675
T
V
Y
E
D
G
D
S
I
Q
V
G
L
V
Q
Site 109
S1685
V
G
L
V
Q
Y
N
S
D
P
T
D
E
F
F
Site 110
T1688
V
Q
Y
N
S
D
P
T
D
E
F
F
L
K
D
Site 111
S1697
E
F
F
L
K
D
F
S
T
K
R
Q
I
I
D
Site 112
T1698
F
F
L
K
D
F
S
T
K
R
Q
I
I
D
A
Site 113
T1719
K
G
G
R
H
A
N
T
K
V
G
L
E
H
L
Site 114
S1763
V
E
D
A
Q
D
V
S
L
A
L
T
Q
R
G
Site 115
S1783
V
G
V
R
N
I
D
S
E
E
V
G
K
I
A
Site 116
S1791
E
E
V
G
K
I
A
S
N
S
A
T
A
F
R
Site 117
S1806
V
G
N
V
Q
E
L
S
E
L
S
E
Q
V
L
Site 118
T1823
L
H
D
A
M
H
E
T
L
C
P
G
V
T
D
Site 119
S1876
I
S
Q
M
H
R
V
S
C
S
G
G
R
S
P
Site 120
S1878
Q
M
H
R
V
S
C
S
G
G
R
S
P
T
V
Site 121
S1888
R
S
P
T
V
R
V
S
V
V
A
N
T
P
S
Site 122
Y1906
E
A
F
D
F
D
E
Y
Q
P
E
M
L
E
K
Site 123
S1919
E
K
F
R
N
M
R
S
Q
H
P
Y
V
L
T
Site 124
Y1923
N
M
R
S
Q
H
P
Y
V
L
T
E
D
T
L
Site 125
T1929
P
Y
V
L
T
E
D
T
L
K
V
Y
L
N
K
Site 126
Y1933
T
E
D
T
L
K
V
Y
L
N
K
F
R
Q
S
Site 127
S1940
Y
L
N
K
F
R
Q
S
S
P
D
S
V
K
V
Site 128
S1941
L
N
K
F
R
Q
S
S
P
D
S
V
K
V
V
Site 129
S1944
F
R
Q
S
S
P
D
S
V
K
V
V
I
H
F
Site 130
S1966
L
A
D
L
H
R
A
S
E
N
L
R
Q
E
G
Site 131
Y2002
E
F
G
R
G
F
M
Y
D
R
P
L
R
L
N
Site 132
Y2015
L
N
L
L
D
L
D
Y
E
L
A
E
Q
L
D
Site 133
S2048
G
D
R
G
P
I
G
S
I
G
P
K
G
I
P
Site 134
Y2060
G
I
P
G
E
D
G
Y
R
G
Y
P
G
D
E
Site 135
Y2063
G
E
D
G
Y
R
G
Y
P
G
D
E
G
G
P
Site 136
S2096
G
Q
R
G
V
K
G
S
R
G
F
P
G
E
K
Site 137
S2126
G
D
K
G
L
P
G
S
S
G
E
K
G
N
P
Site 138
S2127
D
K
G
L
P
G
S
S
G
E
K
G
N
P
G
Site 139
S2164
P
G
N
P
G
Q
D
S
Q
E
R
G
P
K
G
Site 140
S2248
L
I
G
E
Q
G
I
S
G
P
R
G
S
G
G
Site 141
S2253
G
I
S
G
P
R
G
S
G
G
A
A
G
A
P
Site 142
T2266
A
P
G
E
R
G
R
T
G
P
L
G
R
K
G
Site 143
T2293
N
R
G
P
R
G
E
T
G
D
D
G
R
D
G
Site 144
S2303
D
G
R
D
G
V
G
S
E
G
R
R
G
K
K
Site 145
Y2318
G
E
R
G
F
P
G
Y
P
G
P
K
G
N
P
Site 146
T2333
G
E
P
G
L
N
G
T
T
G
P
K
G
I
R
Site 147
S2346
I
R
G
R
R
G
N
S
G
P
P
G
I
V
G
Site 148
Y2360
G
Q
K
G
D
P
G
Y
P
G
P
A
G
P
K
Site 149
S2373
P
K
G
N
R
G
D
S
I
D
Q
C
A
L
I
Site 150
T2417
S
E
G
V
N
Q
D
T
F
G
R
M
R
D
V
Site 151
S2437
N
D
L
T
I
A
E
S
N
C
P
R
G
A
R
Site 152
S2463
T
E
I
R
F
A
D
S
K
R
K
S
V
L
L
Site 153
S2467
F
A
D
S
K
R
K
S
V
L
L
D
K
I
K
Site 154
S2482
N
L
Q
V
A
L
T
S
K
Q
Q
S
L
E
T
Site 155
S2486
A
L
T
S
K
Q
Q
S
L
E
T
A
M
S
F
Site 156
S2492
Q
S
L
E
T
A
M
S
F
V
A
R
N
T
F
Site 157
T2498
M
S
F
V
A
R
N
T
F
K
R
V
R
N
G
Site 158
S2516
R
K
V
A
V
F
F
S
N
T
P
T
R
A
S
Site 159
T2518
V
A
V
F
F
S
N
T
P
T
R
A
S
P
Q
Site 160
T2520
V
F
F
S
N
T
P
T
R
A
S
P
Q
L
R
Site 161
S2523
S
N
T
P
T
R
A
S
P
Q
L
R
E
A
V
Site 162
T2539
K
L
S
D
A
G
I
T
P
L
F
L
T
R
Q
Site 163
S2601
D
P
S
C
G
F
G
S
W
R
P
S
F
R
D
Site 164
S2605
G
F
G
S
W
R
P
S
F
R
D
R
R
A
A
Site 165
S2614
R
D
R
R
A
A
G
S
D
V
D
I
D
M
A
Site 166
Y2641
Q
F
N
E
M
K
K
Y
I
A
Y
L
V
R
Q
Site 167
Y2644
E
M
K
K
Y
I
A
Y
L
V
R
Q
L
D
M
Site 168
S2652
L
V
R
Q
L
D
M
S
P
D
P
K
A
S
Q
Site 169
S2674
V
Q
H
A
P
S
E
S
V
D
N
A
S
M
P
Site 170
S2679
S
E
S
V
D
N
A
S
M
P
P
V
K
V
E
Site 171
S2688
P
P
V
K
V
E
F
S
L
T
D
Y
G
S
K
Site 172
T2690
V
K
V
E
F
S
L
T
D
Y
G
S
K
E
K
Site 173
Y2692
V
E
F
S
L
T
D
Y
G
S
K
E
K
L
V
Site 174
S2694
F
S
L
T
D
Y
G
S
K
E
K
L
V
D
F
Site 175
S2703
E
K
L
V
D
F
L
S
R
G
M
T
Q
L
Q
Site 176
T2707
D
F
L
S
R
G
M
T
Q
L
Q
G
T
R
A
Site 177
S2717
Q
G
T
R
A
L
G
S
A
I
E
Y
T
I
E
Site 178
Y2767
L
Q
A
K
C
K
G
Y
F
F
V
V
L
G
I
Site 179
T2785
V
N
I
K
E
V
Y
T
F
A
S
E
P
N
D
Site 180
S2801
F
F
K
L
V
D
K
S
T
E
L
N
E
E
P
Site 181
T2802
F
K
L
V
D
K
S
T
E
L
N
E
E
P
L
Site 182
S2818
R
F
G
R
L
L
P
S
F
V
S
S
E
N
A
Site 183
Y2827
V
S
S
E
N
A
F
Y
L
S
P
D
I
R
K
Site 184
S2829
S
E
N
A
F
Y
L
S
P
D
I
R
K
Q
C
Site 185
S2864
N
V
P
N
N
V
T
S
S
P
T
S
N
P
V
Site 186
S2865
V
P
N
N
V
T
S
S
P
T
S
N
P
V
T
Site 187
S2868
N
V
T
S
S
P
T
S
N
P
V
T
T
T
K
Site 188
T2872
S
P
T
S
N
P
V
T
T
T
K
P
V
T
T
Site 189
T2898
T
T
T
T
K
P
V
T
I
I
N
Q
P
S
V
Site 190
T2927
A
K
P
V
A
T
K
T
A
T
V
R
P
P
V
Site 191
T2984
P
A
A
T
K
P
A
T
T
K
P
M
V
K
M
Site 192
Y3018
R
P
E
P
P
G
P
Y
F
Y
D
L
T
V
T
Site 193
Y3020
E
P
P
G
P
Y
F
Y
D
L
T
V
T
S
A
Site 194
T3023
G
P
Y
F
Y
D
L
T
V
T
S
A
H
D
Q
Site 195
S3031
V
T
S
A
H
D
Q
S
L
V
L
K
Q
N
L
Site 196
T3069
L
R
S
Q
V
R
A
T
Y
H
G
S
F
S
T
Site 197
Y3070
R
S
Q
V
R
A
T
Y
H
G
S
F
S
T
K
Site 198
S3073
V
R
A
T
Y
H
G
S
F
S
T
K
K
S
Q
Site 199
S3075
A
T
Y
H
G
S
F
S
T
K
K
S
Q
P
P
Site 200
S3079
G
S
F
S
T
K
K
S
Q
P
P
P
P
Q
P
Site 201
S3089
P
P
P
Q
P
A
R
S
A
S
S
S
T
I
N
Site 202
S3091
P
Q
P
A
R
S
A
S
S
S
T
I
N
L
M
Site 203
S3093
P
A
R
S
A
S
S
S
T
I
N
L
M
V
S
Site 204
T3107
S
T
E
P
L
A
L
T
E
T
D
I
C
K
L
Site 205
T3109
E
P
L
A
L
T
E
T
D
I
C
K
L
P
K
Site 206
T3120
K
L
P
K
D
E
G
T
C
R
D
F
I
L
K
Site 207
Y3129
R
D
F
I
L
K
W
Y
Y
D
P
N
T
K
S
Site 208
Y3142
K
S
C
A
R
F
W
Y
G
G
C
G
G
N
E
Site 209
S3154
G
N
E
N
K
F
G
S
Q
K
E
C
E
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation