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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
factor V
Full Name:
Coagulation factor V
Alias:
Activated protein C cofactor; Coagulation factor V; F5; FA5; Proaccelerin, labile factor
Type:
Mass (Da):
251671
Number AA:
2224
UniProt ID:
P12259
International Prot ID:
IPI00478809
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005886
GO:0031093
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005507
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0007596
GO:0007155
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
T
S
W
V
G
W
G
S
Q
G
T
E
A
A
Q
Site 2
S44
A
A
Q
G
I
S
W
S
Y
R
P
E
P
T
N
Site 3
S52
Y
R
P
E
P
T
N
S
S
L
N
L
S
V
T
Site 4
S53
R
P
E
P
T
N
S
S
L
N
L
S
V
T
S
Site 5
S57
T
N
S
S
L
N
L
S
V
T
S
F
K
K
I
Site 6
Y66
T
S
F
K
K
I
V
Y
R
E
Y
E
P
Y
F
Site 7
Y69
K
K
I
V
Y
R
E
Y
E
P
Y
F
K
K
E
Site 8
Y72
V
Y
R
E
Y
E
P
Y
F
K
K
E
K
P
Q
Site 9
S80
F
K
K
E
K
P
Q
S
T
I
S
G
L
L
G
Site 10
T81
K
K
E
K
P
Q
S
T
I
S
G
L
L
G
P
Site 11
S111
N
K
A
D
K
P
L
S
I
H
P
Q
G
I
R
Site 12
S120
H
P
Q
G
I
R
Y
S
K
L
S
E
G
A
S
Site 13
S123
G
I
R
Y
S
K
L
S
E
G
A
S
Y
L
D
Site 14
S127
S
K
L
S
E
G
A
S
Y
L
D
H
T
F
P
Site 15
Y128
K
L
S
E
G
A
S
Y
L
D
H
T
F
P
A
Site 16
T132
G
A
S
Y
L
D
H
T
F
P
A
E
K
M
D
Site 17
Y148
A
V
A
P
G
R
E
Y
T
Y
E
W
S
I
S
Site 18
T149
V
A
P
G
R
E
Y
T
Y
E
W
S
I
S
E
Site 19
Y150
A
P
G
R
E
Y
T
Y
E
W
S
I
S
E
D
Site 20
S155
Y
T
Y
E
W
S
I
S
E
D
S
G
P
T
H
Site 21
S158
E
W
S
I
S
E
D
S
G
P
T
H
D
D
P
Site 22
Y172
P
P
C
L
T
H
I
Y
Y
S
H
E
N
L
I
Site 23
Y173
P
C
L
T
H
I
Y
Y
S
H
E
N
L
I
E
Site 24
T206
T
E
G
G
T
Q
K
T
F
D
K
Q
I
V
L
Site 25
S221
L
F
A
V
F
D
E
S
K
S
W
S
Q
S
S
Site 26
S223
A
V
F
D
E
S
K
S
W
S
Q
S
S
S
L
Site 27
S225
F
D
E
S
K
S
W
S
Q
S
S
S
L
M
Y
Site 28
S227
E
S
K
S
W
S
Q
S
S
S
L
M
Y
T
V
Site 29
S229
K
S
W
S
Q
S
S
S
L
M
Y
T
V
N
G
Site 30
Y232
S
Q
S
S
S
L
M
Y
T
V
N
G
Y
V
N
Site 31
T233
Q
S
S
S
L
M
Y
T
V
N
G
Y
V
N
G
Site 32
Y237
L
M
Y
T
V
N
G
Y
V
N
G
T
M
P
D
Site 33
S261
S
W
H
L
L
G
M
S
S
G
P
E
L
F
S
Site 34
S268
S
S
G
P
E
L
F
S
I
H
F
N
G
Q
V
Site 35
S284
E
Q
N
H
H
K
V
S
A
I
T
L
V
S
A
Site 36
T299
T
S
T
T
A
N
M
T
V
G
P
E
G
K
W
Site 37
S310
E
G
K
W
I
I
S
S
L
T
P
K
H
L
Q
Site 38
T312
K
W
I
I
S
S
L
T
P
K
H
L
Q
A
G
Site 39
Y323
L
Q
A
G
M
Q
A
Y
I
D
I
K
N
C
P
Site 40
Y352
R
H
M
K
R
W
E
Y
F
I
A
A
E
E
V
Site 41
Y375
P
A
N
M
D
K
K
Y
R
S
Q
H
L
D
N
Site 42
S377
N
M
D
K
K
Y
R
S
Q
H
L
D
N
F
S
Site 43
Y391
S
N
Q
I
G
K
H
Y
K
K
V
M
Y
T
Q
Site 44
Y399
K
K
V
M
Y
T
Q
Y
E
D
E
S
F
T
K
Site 45
T408
D
E
S
F
T
K
H
T
V
N
P
N
M
K
E
Site 46
T430
I
R
A
Q
V
R
D
T
L
K
I
V
F
K
N
Site 47
Y443
K
N
M
A
S
R
P
Y
S
I
Y
P
H
G
V
Site 48
S444
N
M
A
S
R
P
Y
S
I
Y
P
H
G
V
T
Site 49
Y446
A
S
R
P
Y
S
I
Y
P
H
G
V
T
F
S
Site 50
T451
S
I
Y
P
H
G
V
T
F
S
P
Y
E
D
E
Site 51
S453
Y
P
H
G
V
T
F
S
P
Y
E
D
E
V
N
Site 52
Y455
H
G
V
T
F
S
P
Y
E
D
E
V
N
S
S
Site 53
S462
Y
E
D
E
V
N
S
S
F
T
S
G
R
N
N
Site 54
S465
E
V
N
S
S
F
T
S
G
R
N
N
T
M
I
Site 55
T470
F
T
S
G
R
N
N
T
M
I
R
A
V
Q
P
Site 56
Y483
Q
P
G
E
T
Y
T
Y
K
W
N
I
L
E
F
Site 57
Y505
A
Q
C
L
T
R
P
Y
Y
S
D
V
D
I
M
Site 58
Y506
Q
C
L
T
R
P
Y
Y
S
D
V
D
I
M
R
Site 59
S528
G
L
L
L
I
C
K
S
R
S
L
D
R
R
G
Site 60
S530
L
L
I
C
K
S
R
S
L
D
R
R
G
I
Q
Site 61
Y558
F
D
E
N
K
S
W
Y
L
E
D
N
I
N
K
Site 62
Y581
K
R
D
D
P
K
F
Y
E
S
N
I
M
S
T
Site 63
T623
G
T
Q
N
E
I
L
T
I
H
F
T
G
H
S
Site 64
T640
Y
G
K
R
H
E
D
T
L
T
L
F
P
M
R
Site 65
T642
K
R
H
E
D
T
L
T
L
F
P
M
R
G
E
Site 66
S650
L
F
P
M
R
G
E
S
V
T
V
T
M
D
N
Site 67
T652
P
M
R
G
E
S
V
T
V
T
M
D
N
V
G
Site 68
T654
R
G
E
S
V
T
V
T
M
D
N
V
G
T
W
Site 69
T664
N
V
G
T
W
M
L
T
S
M
N
S
S
P
R
Site 70
S665
V
G
T
W
M
L
T
S
M
N
S
S
P
R
S
Site 71
S668
W
M
L
T
S
M
N
S
S
P
R
S
K
K
L
Site 72
S669
M
L
T
S
M
N
S
S
P
R
S
K
K
L
R
Site 73
S672
S
M
N
S
S
P
R
S
K
K
L
R
L
K
F
Site 74
S692
I
P
D
D
D
E
D
S
Y
E
I
F
E
P
P
Site 75
Y693
P
D
D
D
E
D
S
Y
E
I
F
E
P
P
E
Site 76
S701
E
I
F
E
P
P
E
S
T
V
M
A
T
R
K
Site 77
T706
P
E
S
T
V
M
A
T
R
K
M
H
D
R
L
Site 78
S720
L
E
P
E
D
E
E
S
D
A
D
Y
D
Y
Q
Site 79
Y724
D
E
E
S
D
A
D
Y
D
Y
Q
N
R
L
A
Site 80
Y726
E
S
D
A
D
Y
D
Y
Q
N
R
L
A
A
A
Site 81
S738
A
A
A
L
G
I
R
S
F
R
N
S
S
L
N
Site 82
S742
G
I
R
S
F
R
N
S
S
L
N
Q
E
E
E
Site 83
S743
I
R
S
F
R
N
S
S
L
N
Q
E
E
E
E
Site 84
T754
E
E
E
E
F
N
L
T
A
L
A
L
E
N
G
Site 85
S775
N
T
D
I
I
V
G
S
N
Y
S
S
P
S
N
Site 86
Y777
D
I
I
V
G
S
N
Y
S
S
P
S
N
I
S
Site 87
S778
I
I
V
G
S
N
Y
S
S
P
S
N
I
S
K
Site 88
S779
I
V
G
S
N
Y
S
S
P
S
N
I
S
K
F
Site 89
S781
G
S
N
Y
S
S
P
S
N
I
S
K
F
T
V
Site 90
T804
A
P
S
H
Q
Q
A
T
T
A
G
S
P
L
R
Site 91
S808
Q
Q
A
T
T
A
G
S
P
L
R
H
L
I
G
Site 92
S818
R
H
L
I
G
K
N
S
V
L
N
S
S
T
A
Site 93
S822
G
K
N
S
V
L
N
S
S
T
A
E
H
S
S
Site 94
S823
K
N
S
V
L
N
S
S
T
A
E
H
S
S
P
Site 95
T824
N
S
V
L
N
S
S
T
A
E
H
S
S
P
Y
Site 96
S828
N
S
S
T
A
E
H
S
S
P
Y
S
E
D
P
Site 97
S829
S
S
T
A
E
H
S
S
P
Y
S
E
D
P
I
Site 98
S832
A
E
H
S
S
P
Y
S
E
D
P
I
E
D
P
Site 99
S859
L
G
A
G
E
F
K
S
Q
E
H
A
K
H
K
Site 100
S895
H
K
V
G
R
H
L
S
Q
D
T
G
S
P
S
Site 101
T898
G
R
H
L
S
Q
D
T
G
S
P
S
G
M
R
Site 102
S900
H
L
S
Q
D
T
G
S
P
S
G
M
R
P
W
Site 103
S902
S
Q
D
T
G
S
P
S
G
M
R
P
W
E
D
Site 104
S912
R
P
W
E
D
L
P
S
Q
D
T
G
S
P
S
Site 105
T915
E
D
L
P
S
Q
D
T
G
S
P
S
R
M
R
Site 106
S917
L
P
S
Q
D
T
G
S
P
S
R
M
R
P
W
Site 107
S929
R
P
W
K
D
P
P
S
D
L
L
L
L
K
Q
Site 108
S937
D
L
L
L
L
K
Q
S
N
S
S
K
I
L
V
Site 109
S939
L
L
L
K
Q
S
N
S
S
K
I
L
V
G
R
Site 110
S951
V
G
R
W
H
L
A
S
E
K
G
S
Y
E
I
Site 111
S955
H
L
A
S
E
K
G
S
Y
E
I
I
Q
D
T
Site 112
Y956
L
A
S
E
K
G
S
Y
E
I
I
Q
D
T
D
Site 113
T962
S
Y
E
I
I
Q
D
T
D
E
D
T
A
V
N
Site 114
S974
A
V
N
N
W
L
I
S
P
Q
N
A
S
R
A
Site 115
S985
A
S
R
A
W
G
E
S
T
P
L
A
N
K
P
Site 116
T986
S
R
A
W
G
E
S
T
P
L
A
N
K
P
G
Site 117
S996
A
N
K
P
G
K
Q
S
G
H
P
K
F
P
R
Site 118
S1008
F
P
R
V
R
H
K
S
L
Q
V
R
Q
D
G
Site 119
S1018
V
R
Q
D
G
G
K
S
R
L
K
K
S
Q
F
Site 120
S1023
G
K
S
R
L
K
K
S
Q
F
L
I
K
T
R
Site 121
S1044
H
T
H
H
A
P
L
S
P
R
T
F
H
P
L
Site 122
T1047
H
A
P
L
S
P
R
T
F
H
P
L
R
S
E
Site 123
S1053
R
T
F
H
P
L
R
S
E
A
Y
N
T
F
S
Site 124
Y1056
H
P
L
R
S
E
A
Y
N
T
F
S
E
R
R
Site 125
T1058
L
R
S
E
A
Y
N
T
F
S
E
R
R
L
K
Site 126
S1060
S
E
A
Y
N
T
F
S
E
R
R
L
K
H
S
Site 127
S1067
S
E
R
R
L
K
H
S
L
V
L
H
K
S
N
Site 128
S1073
H
S
L
V
L
H
K
S
N
E
T
S
L
P
T
Site 129
S1077
L
H
K
S
N
E
T
S
L
P
T
D
L
N
Q
Site 130
S1104
L
P
D
H
N
Q
N
S
S
N
D
T
G
Q
A
Site 131
T1108
N
Q
N
S
S
N
D
T
G
Q
A
S
C
P
P
Site 132
S1112
S
N
D
T
G
Q
A
S
C
P
P
G
L
Y
Q
Site 133
Y1118
A
S
C
P
P
G
L
Y
Q
T
V
P
P
E
E
Site 134
T1120
C
P
P
G
L
Y
Q
T
V
P
P
E
E
H
Y
Site 135
T1129
P
P
E
E
H
Y
Q
T
F
P
I
Q
D
P
D
Site 136
S1140
Q
D
P
D
Q
M
H
S
T
S
D
P
S
H
R
Site 137
T1141
D
P
D
Q
M
H
S
T
S
D
P
S
H
R
S
Site 138
S1142
P
D
Q
M
H
S
T
S
D
P
S
H
R
S
S
Site 139
S1145
M
H
S
T
S
D
P
S
H
R
S
S
S
P
E
Site 140
S1148
T
S
D
P
S
H
R
S
S
S
P
E
L
S
E
Site 141
S1149
S
D
P
S
H
R
S
S
S
P
E
L
S
E
M
Site 142
S1150
D
P
S
H
R
S
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Site 294
T2154
E
M
Y
V
K
S
Y
T
I
H
Y
S
E
Q
G
Site 295
Y2167
Q
G
V
E
W
K
P
Y
R
L
K
S
S
M
V
Site 296
S2171
W
K
P
Y
R
L
K
S
S
M
V
D
K
I
F
Site 297
S2172
K
P
Y
R
L
K
S
S
M
V
D
K
I
F
E
Site 298
S2198
F
F
N
P
P
I
I
S
R
F
I
R
V
I
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation