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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IMPDH2
Full Name:
Inosine-5'-monophosphate dehydrogenase 2
Alias:
EC 1.1.1.205; IMD2; IMDH2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMPD 2; IMPD2; IMPDH-II
Type:
EC 1.1.1.205; Xenobiotic Metabolism - drug metabolism - other enzymes; Oxidoreductase; Nucleotide Metabolism - purine
Mass (Da):
55805
Number AA:
514
UniProt ID:
P12268
International Prot ID:
IPI00291510
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003938
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006177
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
Y
L
I
S
G
G
T
S
Y
V
P
D
D
G
L
Site 2
T19
Y
V
P
D
D
G
L
T
A
Q
Q
L
F
N
C
Site 3
T52
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
I
Site 4
T63
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
Site 5
S68
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
Site 6
Y110
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
Site 7
T116
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
Site 8
S122
I
T
D
P
V
V
L
S
P
K
D
R
V
R
D
Site 9
T147
C
G
I
P
I
T
D
T
G
R
M
G
S
R
L
Site 10
S159
S
R
L
V
G
I
I
S
S
R
D
I
D
F
L
Site 11
S160
R
L
V
G
I
I
S
S
R
D
I
D
F
L
K
Site 12
Y233
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
Site 13
Y258
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
Site 14
S280
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
Site 15
Y289
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
Site 16
Y294
I
K
Y
I
K
D
K
Y
P
N
L
Q
V
I
G
Site 17
T345
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Site 18
Y348
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
Site 19
Y353
A
V
Y
K
V
S
E
Y
A
R
R
F
G
V
P
Site 20
Y400
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
Site 21
S403
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Site 22
Y411
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
Site 23
S416
K
K
Y
R
G
M
G
S
L
D
A
M
D
K
H
Site 24
S425
D
A
M
D
K
H
L
S
S
Q
N
R
Y
F
S
Site 25
S426
A
M
D
K
H
L
S
S
Q
N
R
Y
F
S
E
Site 26
Y430
H
L
S
S
Q
N
R
Y
F
S
E
A
D
K
I
Site 27
S432
S
S
Q
N
R
Y
F
S
E
A
D
K
I
K
V
Site 28
S452
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
Site 29
Y459
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
Site 30
S475
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
Site 31
T477
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
Site 32
S485
Q
V
R
A
M
M
Y
S
G
E
L
K
F
E
K
Site 33
S495
L
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
Site 34
S496
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
Site 35
S505
Q
V
E
G
G
V
H
S
L
H
S
Y
E
K
R
Site 36
S508
G
G
V
H
S
L
H
S
Y
E
K
R
L
F
_
Site 37
Y509
G
V
H
S
L
H
S
Y
E
K
R
L
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation