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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SKI
Full Name:
Ski oncogene
Alias:
Proto-oncogene c-Ski
Type:
Mass (Da):
80005
Number AA:
728
UniProt ID:
P12755
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
P
H
P
G
L
Q
K
T
L
E
Q
F
H
L
S
Site 2
S27
T
L
E
Q
F
H
L
S
S
M
S
S
L
G
G
Site 3
S28
L
E
Q
F
H
L
S
S
M
S
S
L
G
G
P
Site 4
S30
Q
F
H
L
S
S
M
S
S
L
G
G
P
A
A
Site 5
S39
L
G
G
P
A
A
F
S
A
R
W
A
Q
E
A
Site 6
S94
P
G
P
F
F
M
P
S
D
R
S
T
E
R
C
Site 7
S97
F
F
M
P
S
D
R
S
T
E
R
C
E
T
V
Site 8
T98
F
M
P
S
D
R
S
T
E
R
C
E
T
V
L
Site 9
T103
R
S
T
E
R
C
E
T
V
L
E
G
E
T
I
Site 10
S135
N
S
V
L
R
D
F
S
L
Q
Q
I
N
A
V
Site 11
Y149
V
C
D
E
L
H
I
Y
C
S
R
C
T
A
D
Site 12
T180
S
C
G
L
I
T
K
T
D
A
E
R
L
C
N
Site 13
Y195
A
L
L
Y
G
G
A
Y
P
P
P
C
K
K
E
Site 14
S217
G
L
E
L
S
E
R
S
V
R
V
Y
H
E
C
Site 15
Y221
S
E
R
S
V
R
V
Y
H
E
C
F
G
K
C
Site 16
Y284
D
S
A
N
W
R
A
Y
I
L
L
S
Q
D
Y
Site 17
S288
W
R
A
Y
I
L
L
S
Q
D
Y
T
G
K
E
Site 18
Y291
Y
I
L
L
S
Q
D
Y
T
G
K
E
E
Q
A
Site 19
T292
I
L
L
S
Q
D
Y
T
G
K
E
E
Q
A
R
Site 20
Y313
D
V
K
E
K
F
D
Y
G
N
K
Y
K
R
R
Site 21
Y317
K
F
D
Y
G
N
K
Y
K
R
R
V
P
R
V
Site 22
S325
K
R
R
V
P
R
V
S
S
E
P
P
A
S
I
Site 23
S326
R
R
V
P
R
V
S
S
E
P
P
A
S
I
R
Site 24
S331
V
S
S
E
P
P
A
S
I
R
P
K
T
D
D
Site 25
T336
P
A
S
I
R
P
K
T
D
D
T
S
S
Q
S
Site 26
T339
I
R
P
K
T
D
D
T
S
S
Q
S
P
A
P
Site 27
S340
R
P
K
T
D
D
T
S
S
Q
S
P
A
P
S
Site 28
S341
P
K
T
D
D
T
S
S
Q
S
P
A
P
S
E
Site 29
S343
T
D
D
T
S
S
Q
S
P
A
P
S
E
K
D
Site 30
S347
S
S
Q
S
P
A
P
S
E
K
D
K
P
S
S
Site 31
S353
P
S
E
K
D
K
P
S
S
W
L
R
T
L
A
Site 32
S354
S
E
K
D
K
P
S
S
W
L
R
T
L
A
G
Site 33
T358
K
P
S
S
W
L
R
T
L
A
G
S
S
N
K
Site 34
S362
W
L
R
T
L
A
G
S
S
N
K
S
L
G
C
Site 35
S366
L
A
G
S
S
N
K
S
L
G
C
V
H
P
R
Site 36
S377
V
H
P
R
Q
R
L
S
A
F
R
P
W
S
P
Site 37
S383
L
S
A
F
R
P
W
S
P
A
V
S
A
S
E
Site 38
S387
R
P
W
S
P
A
V
S
A
S
E
K
E
L
S
Site 39
S389
W
S
P
A
V
S
A
S
E
K
E
L
S
P
H
Site 40
S394
S
A
S
E
K
E
L
S
P
H
L
P
A
L
I
Site 41
S404
L
P
A
L
I
R
D
S
F
Y
S
Y
K
S
F
Site 42
Y406
A
L
I
R
D
S
F
Y
S
Y
K
S
F
E
T
Site 43
S407
L
I
R
D
S
F
Y
S
Y
K
S
F
E
T
A
Site 44
Y408
I
R
D
S
F
Y
S
Y
K
S
F
E
T
A
V
Site 45
S410
D
S
F
Y
S
Y
K
S
F
E
T
A
V
A
P
Site 46
T448
R
A
P
E
P
L
A
T
C
T
Q
P
R
K
R
Site 47
T450
P
E
P
L
A
T
C
T
Q
P
R
K
R
K
L
Site 48
T458
Q
P
R
K
R
K
L
T
V
D
T
P
G
A
P
Site 49
T461
K
R
K
L
T
V
D
T
P
G
A
P
E
T
L
Site 50
T467
D
T
P
G
A
P
E
T
L
A
P
V
A
A
P
Site 51
S480
A
P
E
E
D
K
D
S
E
A
E
V
E
V
E
Site 52
S488
E
A
E
V
E
V
E
S
R
E
E
F
T
S
S
Site 53
T493
V
E
S
R
E
E
F
T
S
S
L
S
S
L
S
Site 54
S494
E
S
R
E
E
F
T
S
S
L
S
S
L
S
S
Site 55
S495
S
R
E
E
F
T
S
S
L
S
S
L
S
S
P
Site 56
S497
E
E
F
T
S
S
L
S
S
L
S
S
P
S
F
Site 57
S498
E
F
T
S
S
L
S
S
L
S
S
P
S
F
T
Site 58
S500
T
S
S
L
S
S
L
S
S
P
S
F
T
S
S
Site 59
S501
S
S
L
S
S
L
S
S
P
S
F
T
S
S
S
Site 60
S503
L
S
S
L
S
S
P
S
F
T
S
S
S
S
A
Site 61
T505
S
L
S
S
P
S
F
T
S
S
S
S
A
K
D
Site 62
S507
S
S
P
S
F
T
S
S
S
S
A
K
D
L
G
Site 63
S508
S
P
S
F
T
S
S
S
S
A
K
D
L
G
S
Site 64
S509
P
S
F
T
S
S
S
S
A
K
D
L
G
S
P
Site 65
S515
S
S
A
K
D
L
G
S
P
G
A
R
A
L
P
Site 66
S578
V
K
Q
E
E
K
L
S
A
A
L
Q
A
K
R
Site 67
S586
A
A
L
Q
A
K
R
S
L
H
Q
E
L
E
F
Site 68
T606
K
E
K
L
R
E
A
T
E
A
K
R
N
L
R
Site 69
S633
K
M
K
E
A
N
E
S
R
L
R
L
K
R
E
Site 70
Y663
A
G
R
L
R
A
K
Y
S
A
Q
I
E
D
L
Site 71
S664
G
R
L
R
A
K
Y
S
A
Q
I
E
D
L
Q
Site 72
S720
A
R
P
E
A
A
G
S
E
G
A
A
E
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation