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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SKIL
Full Name:
Ski-like protein
Alias:
Ski-related oncogene;Ski-related protein
Type:
Mass (Da):
77004
Number AA:
684
UniProt ID:
P12757
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
N
L
Q
T
N
F
S
L
V
Q
G
S
T
K
Site 2
S26
N
G
M
G
D
D
G
S
P
P
A
K
K
M
I
Site 3
T48
K
T
I
N
K
V
P
T
V
K
K
E
H
L
D
Site 4
Y57
K
K
E
H
L
D
D
Y
G
E
A
P
V
E
T
Site 5
T74
E
H
V
K
R
T
C
T
S
V
P
E
T
L
H
Site 6
S75
H
V
K
R
T
C
T
S
V
P
E
T
L
H
L
Site 7
T79
T
C
T
S
V
P
E
T
L
H
L
N
P
S
L
Site 8
S85
E
T
L
H
L
N
P
S
L
K
H
T
L
A
Q
Site 9
T89
L
N
P
S
L
K
H
T
L
A
Q
F
H
L
S
Site 10
S96
T
L
A
Q
F
H
L
S
S
Q
S
S
L
G
G
Site 11
S97
L
A
Q
F
H
L
S
S
Q
S
S
L
G
G
P
Site 12
S99
Q
F
H
L
S
S
Q
S
S
L
G
G
P
A
A
Site 13
S108
L
G
G
P
A
A
F
S
A
R
H
S
Q
E
S
Site 14
S112
A
A
F
S
A
R
H
S
Q
E
S
M
S
P
T
Site 15
S115
S
A
R
H
S
Q
E
S
M
S
P
T
V
F
L
Site 16
S117
R
H
S
Q
E
S
M
S
P
T
V
F
L
P
L
Site 17
T119
S
Q
E
S
M
S
P
T
V
F
L
P
L
P
S
Site 18
S138
P
G
P
L
L
I
P
S
D
S
S
T
E
L
T
Site 19
S140
P
L
L
I
P
S
D
S
S
T
E
L
T
Q
T
Site 20
T145
S
D
S
S
T
E
L
T
Q
T
V
L
E
G
E
Site 21
T147
S
S
T
E
L
T
Q
T
V
L
E
G
E
S
I
Site 22
T179
N
S
V
L
R
E
F
T
L
Q
Q
I
N
T
V
Site 23
Y191
N
T
V
C
D
E
L
Y
I
Y
C
S
R
C
T
Site 24
Y193
V
C
D
E
L
Y
I
Y
C
S
R
C
T
S
D
Site 25
T238
N
A
L
L
R
P
R
T
F
P
Q
N
G
S
V
Site 26
S244
R
T
F
P
Q
N
G
S
V
L
P
A
K
S
S
Site 27
S251
S
V
L
P
A
K
S
S
L
A
Q
L
K
E
T
Site 28
S260
A
Q
L
K
E
T
G
S
A
F
E
V
E
H
E
Site 29
S307
P
Q
T
F
V
M
H
S
H
R
S
P
D
K
R
Site 30
Y335
Y
L
H
V
N
Q
K
Y
L
G
T
P
E
E
K
Site 31
T338
V
N
Q
K
Y
L
G
T
P
E
E
K
K
L
K
Site 32
S356
E
E
M
K
E
K
F
S
M
R
S
G
K
R
N
Site 33
S359
K
E
K
F
S
M
R
S
G
K
R
N
Q
S
K
Site 34
S365
R
S
G
K
R
N
Q
S
K
T
D
A
P
S
G
Site 35
T367
G
K
R
N
Q
S
K
T
D
A
P
S
G
M
E
Site 36
S371
Q
S
K
T
D
A
P
S
G
M
E
L
Q
S
W
Site 37
Y379
G
M
E
L
Q
S
W
Y
P
V
I
K
Q
E
G
Site 38
S390
K
Q
E
G
D
H
V
S
Q
T
H
S
F
L
H
Site 39
T392
E
G
D
H
V
S
Q
T
H
S
F
L
H
P
S
Site 40
Y400
H
S
F
L
H
P
S
Y
Y
L
Y
M
C
D
K
Site 41
Y401
S
F
L
H
P
S
Y
Y
L
Y
M
C
D
K
V
Site 42
T416
V
A
P
N
V
S
L
T
S
A
V
S
Q
S
K
Site 43
S417
A
P
N
V
S
L
T
S
A
V
S
Q
S
K
E
Site 44
S420
V
S
L
T
S
A
V
S
Q
S
K
E
L
T
K
Site 45
T426
V
S
Q
S
K
E
L
T
K
T
E
A
S
K
S
Site 46
T428
Q
S
K
E
L
T
K
T
E
A
S
K
S
I
S
Site 47
S431
E
L
T
K
T
E
A
S
K
S
I
S
R
Q
S
Site 48
S433
T
K
T
E
A
S
K
S
I
S
R
Q
S
E
K
Site 49
S435
T
E
A
S
K
S
I
S
R
Q
S
E
K
A
H
Site 50
S438
S
K
S
I
S
R
Q
S
E
K
A
H
S
S
G
Site 51
T450
S
S
G
K
L
Q
K
T
V
S
Y
P
D
V
S
Site 52
S452
G
K
L
Q
K
T
V
S
Y
P
D
V
S
L
E
Site 53
Y453
K
L
Q
K
T
V
S
Y
P
D
V
S
L
E
E
Site 54
S457
T
V
S
Y
P
D
V
S
L
E
E
Q
E
K
M
Site 55
T468
Q
E
K
M
D
L
K
T
S
R
E
L
C
S
R
Site 56
S469
E
K
M
D
L
K
T
S
R
E
L
C
S
R
L
Site 57
S479
L
C
S
R
L
D
A
S
I
S
N
N
S
T
S
Site 58
S481
S
R
L
D
A
S
I
S
N
N
S
T
S
K
R
Site 59
S484
D
A
S
I
S
N
N
S
T
S
K
R
K
S
E
Site 60
T485
A
S
I
S
N
N
S
T
S
K
R
K
S
E
S
Site 61
S486
S
I
S
N
N
S
T
S
K
R
K
S
E
S
A
Site 62
S490
N
S
T
S
K
R
K
S
E
S
A
T
C
N
L
Site 63
T494
K
R
K
S
E
S
A
T
C
N
L
V
R
D
I
Site 64
T537
I
M
E
E
V
M
R
T
Y
L
K
Q
Q
E
K
Site 65
Y538
M
E
E
V
M
R
T
Y
L
K
Q
Q
E
K
L
Site 66
S563
Q
M
E
V
K
M
L
S
S
S
K
S
M
K
E
Site 67
S565
E
V
K
M
L
S
S
S
K
S
M
K
E
L
T
Site 68
S567
K
M
L
S
S
S
K
S
M
K
E
L
T
E
E
Site 69
Y597
A
Q
R
M
E
E
F
Y
V
E
Q
K
D
L
E
Site 70
S678
L
K
L
Q
I
L
K
S
S
K
T
A
K
E
_
Site 71
S679
K
L
Q
I
L
K
S
S
K
T
A
K
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation