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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BMP1
Full Name:
Bone morphogenetic protein 1
Alias:
BMP-1; bone morphogenetic protein 1; mammalian tolloid protein; PCOLC; PCP; procollagen C-endopeptidase; procollagen C-proteinase; TLD
Type:
EC 3.4.24.19; Protease
Mass (Da):
111249
Number AA:
986
UniProt ID:
P13497
International Prot ID:
IPI00014021
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005125
GO:0008083
PhosphoSite+
KinaseNET
Biological Process:
GO:0001502
GO:0030154
GO:0001503
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
R
P
L
D
L
A
D
Y
T
Y
D
L
A
E
E
Site 2
T29
P
L
D
L
A
D
Y
T
Y
D
L
A
E
E
D
Site 3
Y30
L
D
L
A
D
Y
T
Y
D
L
A
E
E
D
D
Site 4
S38
D
L
A
E
E
D
D
S
E
P
L
N
Y
K
D
Site 5
Y43
D
D
S
E
P
L
N
Y
K
D
P
C
K
A
A
Site 6
T78
A
V
D
L
R
R
H
T
A
R
K
S
S
I
K
Site 7
S82
R
R
H
T
A
R
K
S
S
I
K
A
A
V
P
Site 8
S83
R
H
T
A
R
K
S
S
I
K
A
A
V
P
G
Site 9
T92
K
A
A
V
P
G
N
T
S
T
P
S
C
Q
S
Site 10
S93
A
A
V
P
G
N
T
S
T
P
S
C
Q
S
T
Site 11
T94
A
V
P
G
N
T
S
T
P
S
C
Q
S
T
N
Site 12
S96
P
G
N
T
S
T
P
S
C
Q
S
T
N
G
Q
Site 13
S99
T
S
T
P
S
C
Q
S
T
N
G
Q
P
Q
R
Site 14
T100
S
T
P
S
C
Q
S
T
N
G
Q
P
Q
R
G
Site 15
S116
C
G
R
W
R
G
R
S
R
S
R
R
A
A
T
Site 16
S118
R
W
R
G
R
S
R
S
R
R
A
A
T
S
R
Site 17
T123
S
R
S
R
R
A
A
T
S
R
P
E
R
V
W
Site 18
S124
R
S
R
R
A
A
T
S
R
P
E
R
V
W
P
Site 19
S146
I
G
G
N
F
T
G
S
Q
R
A
V
F
R
Q
Site 20
S174
L
E
R
T
D
E
D
S
Y
I
V
F
T
Y
R
Site 21
Y175
E
R
T
D
E
D
S
Y
I
V
F
T
Y
R
P
Site 22
Y188
R
P
C
G
C
C
S
Y
V
G
R
R
G
G
G
Site 23
S200
G
G
G
P
Q
A
I
S
I
G
K
N
C
D
K
Site 24
S235
P
D
R
D
R
H
V
S
I
V
R
E
N
I
Q
Site 25
T263
E
V
E
S
L
G
E
T
Y
D
F
D
S
I
M
Site 26
Y264
V
E
S
L
G
E
T
Y
D
F
D
S
I
M
H
Site 27
Y272
D
F
D
S
I
M
H
Y
A
R
N
T
F
S
R
Site 28
Y290
L
D
T
I
V
P
K
Y
E
V
N
G
V
K
P
Site 29
S306
I
G
Q
R
T
R
L
S
K
G
D
I
A
Q
A
Site 30
Y317
I
A
Q
A
R
K
L
Y
K
C
P
A
C
G
E
Site 31
T325
K
C
P
A
C
G
E
T
L
Q
D
S
T
G
N
Site 32
S329
C
G
E
T
L
Q
D
S
T
G
N
F
S
S
P
Site 33
T330
G
E
T
L
Q
D
S
T
G
N
F
S
S
P
E
Site 34
S334
Q
D
S
T
G
N
F
S
S
P
E
Y
P
N
G
Site 35
S335
D
S
T
G
N
F
S
S
P
E
Y
P
N
G
Y
Site 36
Y338
G
N
F
S
S
P
E
Y
P
N
G
Y
S
A
H
Site 37
T355
C
V
W
R
I
S
V
T
P
G
E
K
I
I
L
Site 38
S366
K
I
I
L
N
F
T
S
L
D
L
Y
R
S
R
Site 39
Y370
N
F
T
S
L
D
L
Y
R
S
R
L
C
W
Y
Site 40
Y377
Y
R
S
R
L
C
W
Y
D
Y
V
E
V
R
D
Site 41
Y379
S
R
L
C
W
Y
D
Y
V
E
V
R
D
G
F
Site 42
S399
L
R
G
R
F
C
G
S
K
L
P
E
P
I
V
Site 43
S407
K
L
P
E
P
I
V
S
T
D
S
R
L
W
V
Site 44
S418
R
L
W
V
E
F
R
S
S
S
N
W
V
G
K
Site 45
S419
L
W
V
E
F
R
S
S
S
N
W
V
G
K
G
Site 46
Y443
G
G
D
V
K
K
D
Y
G
H
I
Q
S
P
N
Site 47
Y451
G
H
I
Q
S
P
N
Y
P
D
D
Y
R
P
S
Site 48
Y455
S
P
N
Y
P
D
D
Y
R
P
S
K
V
C
I
Site 49
S479
H
V
G
L
T
F
Q
S
F
E
I
E
R
H
D
Site 50
Y492
H
D
S
C
A
Y
D
Y
L
E
V
R
D
G
H
Site 51
S500
L
E
V
R
D
G
H
S
E
S
S
T
L
I
G
Site 52
T504
D
G
H
S
E
S
S
T
L
I
G
R
Y
C
G
Site 53
Y512
L
I
G
R
Y
C
G
Y
E
K
P
D
D
I
K
Site 54
S520
E
K
P
D
D
I
K
S
T
S
S
R
L
W
L
Site 55
S522
P
D
D
I
K
S
T
S
S
R
L
W
L
K
F
Site 56
S523
D
D
I
K
S
T
S
S
R
L
W
L
K
F
V
Site 57
S552
F
K
E
V
D
E
C
S
R
P
N
R
G
G
C
Site 58
S573
T
L
G
S
Y
K
C
S
C
D
P
G
Y
E
L
Site 59
Y578
K
C
S
C
D
P
G
Y
E
L
A
P
D
K
R
Site 60
S601
F
L
T
K
L
N
G
S
I
T
S
P
G
W
P
Site 61
T603
T
K
L
N
G
S
I
T
S
P
G
W
P
K
E
Site 62
S604
K
L
N
G
S
I
T
S
P
G
W
P
K
E
Y
Site 63
Y611
S
P
G
W
P
K
E
Y
P
P
N
K
N
C
I
Site 64
S630
A
P
T
Q
Y
R
I
S
L
Q
F
D
F
F
E
Site 65
Y646
E
G
N
D
V
C
K
Y
D
F
V
E
V
R
S
Site 66
S659
R
S
G
L
T
A
D
S
K
L
H
G
K
F
C
Site 67
S676
E
K
P
E
V
I
T
S
Q
Y
N
N
M
R
V
Site 68
S687
N
M
R
V
E
F
K
S
D
N
T
V
S
K
K
Site 69
T690
V
E
F
K
S
D
N
T
V
S
K
K
G
F
K
Site 70
S692
F
K
S
D
N
T
V
S
K
K
G
F
K
A
H
Site 71
S702
G
F
K
A
H
F
F
S
D
K
D
E
C
S
K
Site 72
S753
G
C
D
H
K
V
T
S
T
S
G
T
I
T
S
Site 73
S755
D
H
K
V
T
S
T
S
G
T
I
T
S
P
N
Site 74
T757
K
V
T
S
T
S
G
T
I
T
S
P
N
W
P
Site 75
T759
T
S
T
S
G
T
I
T
S
P
N
W
P
D
K
Site 76
S760
S
T
S
G
T
I
T
S
P
N
W
P
D
K
Y
Site 77
Y767
S
P
N
W
P
D
K
Y
P
S
K
K
E
C
T
Site 78
T774
Y
P
S
K
K
E
C
T
W
A
I
S
S
T
P
Site 79
S779
E
C
T
W
A
I
S
S
T
P
G
H
R
V
K
Site 80
T780
C
T
W
A
I
S
S
T
P
G
H
R
V
K
L
Site 81
T788
P
G
H
R
V
K
L
T
F
M
E
M
D
I
E
Site 82
Y842
S
R
M
F
L
R
F
Y
S
D
N
S
V
Q
R
Site 83
S843
R
M
F
L
R
F
Y
S
D
N
S
V
Q
R
K
Site 84
S846
L
R
F
Y
S
D
N
S
V
Q
R
K
G
F
Q
Site 85
S855
Q
R
K
G
F
Q
A
S
H
A
T
E
C
G
G
Site 86
T870
Q
V
R
A
D
V
K
T
K
D
L
Y
S
H
A
Site 87
Y874
D
V
K
T
K
D
L
Y
S
H
A
Q
F
G
D
Site 88
S875
V
K
T
K
D
L
Y
S
H
A
Q
F
G
D
N
Site 89
Y884
A
Q
F
G
D
N
N
Y
P
G
G
V
D
C
E
Site 90
T908
G
V
E
L
V
F
Q
T
F
E
V
E
E
E
T
Site 91
Y919
E
E
E
T
D
C
G
Y
D
Y
M
E
L
F
D
Site 92
Y921
E
T
D
C
G
Y
D
Y
M
E
L
F
D
G
Y
Site 93
Y928
Y
M
E
L
F
D
G
Y
D
S
T
A
P
R
L
Site 94
S930
E
L
F
D
G
Y
D
S
T
A
P
R
L
G
R
Site 95
T931
L
F
D
G
Y
D
S
T
A
P
R
L
G
R
Y
Site 96
Y938
T
A
P
R
L
G
R
Y
C
G
S
G
P
P
E
Site 97
S941
R
L
G
R
Y
C
G
S
G
P
P
E
E
V
Y
Site 98
Y948
S
G
P
P
E
E
V
Y
S
A
G
D
S
V
L
Site 99
S949
G
P
P
E
E
V
Y
S
A
G
D
S
V
L
V
Site 100
S953
E
V
Y
S
A
G
D
S
V
L
V
K
F
H
S
Site 101
S960
S
V
L
V
K
F
H
S
D
D
T
I
T
K
K
Site 102
T963
V
K
F
H
S
D
D
T
I
T
K
K
G
F
H
Site 103
T965
F
H
S
D
D
T
I
T
K
K
G
F
H
L
R
Site 104
Y973
K
K
G
F
H
L
R
Y
T
S
T
K
F
Q
D
Site 105
T974
K
G
F
H
L
R
Y
T
S
T
K
F
Q
D
T
Site 106
S975
G
F
H
L
R
Y
T
S
T
K
F
Q
D
T
L
Site 107
T976
F
H
L
R
Y
T
S
T
K
F
Q
D
T
L
H
Site 108
T981
T
S
T
K
F
Q
D
T
L
H
S
R
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation