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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCG2
Full Name:
Secretogranin-2
Alias:
CHGC; Chromogranin C; Chromogranin-C; SCG-2; Secretogranin II; Secretogranin-2; Secretoneurin; SgII; SN
Type:
Apoptosis; Cytokine; Cell cycle regulation; Motility/polarity/chemotaxis
Mass (Da):
70941
Number AA:
617
UniProt ID:
P13521
International Prot ID:
IPI00009362
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0042056
GO:0005125
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0001525
GO:0043542
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
I
S
G
A
E
A
A
S
F
Q
R
N
Q
L
L
Site 2
S52
E
N
V
Q
K
F
P
S
P
E
M
I
R
A
L
Site 3
Y61
E
M
I
R
A
L
E
Y
I
E
N
L
R
Q
Q
Site 4
S75
Q
A
H
K
E
E
S
S
P
D
Y
N
P
Y
Q
Site 5
Y78
K
E
E
S
S
P
D
Y
N
P
Y
Q
G
V
S
Site 6
Y81
S
S
P
D
Y
N
P
Y
Q
G
V
S
V
P
L
Site 7
S97
Q
K
E
N
G
D
E
S
H
L
P
E
R
D
S
Site 8
S104
S
H
L
P
E
R
D
S
L
S
E
E
D
W
M
Site 9
S106
L
P
E
R
D
S
L
S
E
E
D
W
M
R
I
Site 10
S127
Q
A
E
N
E
P
Q
S
A
P
K
E
N
K
P
Site 11
Y135
A
P
K
E
N
K
P
Y
A
L
N
S
E
K
N
Site 12
S139
N
K
P
Y
A
L
N
S
E
K
N
F
P
M
D
Site 13
Y151
P
M
D
M
S
D
D
Y
E
T
Q
Q
W
P
E
Site 14
Y170
H
M
Q
F
P
P
M
Y
E
E
N
S
R
D
N
Site 15
S174
P
P
M
Y
E
E
N
S
R
D
N
P
F
K
R
Site 16
Y190
N
E
I
V
E
E
Q
Y
T
P
Q
S
L
A
T
Site 17
T191
E
I
V
E
E
Q
Y
T
P
Q
S
L
A
T
L
Site 18
S194
E
E
Q
Y
T
P
Q
S
L
A
T
L
E
S
V
Site 19
S200
Q
S
L
A
T
L
E
S
V
F
Q
E
L
G
K
Site 20
Y226
M
D
E
E
Q
K
L
Y
T
D
D
E
D
D
I
Site 21
Y234
T
D
D
E
D
D
I
Y
K
A
N
N
I
A
Y
Site 22
Y241
Y
K
A
N
N
I
A
Y
E
D
V
V
G
G
E
Site 23
S259
P
V
E
E
K
I
E
S
Q
T
Q
E
E
V
R
Site 24
T261
E
E
K
I
E
S
Q
T
Q
E
E
V
R
D
S
Site 25
S268
T
Q
E
E
V
R
D
S
K
E
N
I
E
K
N
Site 26
S299
E
E
D
L
R
K
E
S
K
D
Q
L
S
D
D
Site 27
S304
K
E
S
K
D
Q
L
S
D
D
V
S
K
V
I
Site 28
S308
D
Q
L
S
D
D
V
S
K
V
I
A
Y
L
K
Site 29
S323
R
L
V
N
A
A
G
S
G
R
L
Q
N
G
Q
Site 30
T336
G
Q
N
G
E
R
A
T
R
L
F
E
K
P
L
Site 31
S345
L
F
E
K
P
L
D
S
Q
S
I
Y
Q
L
I
Site 32
S347
E
K
P
L
D
S
Q
S
I
Y
Q
L
I
E
I
Site 33
Y349
P
L
D
S
Q
S
I
Y
Q
L
I
E
I
S
R
Site 34
T371
D
L
I
E
M
L
K
T
G
E
K
P
N
G
S
Site 35
S378
T
G
E
K
P
N
G
S
V
E
P
E
R
E
L
Site 36
S395
P
V
D
L
D
D
I
S
E
A
D
L
D
H
P
Site 37
S411
L
F
Q
N
R
M
L
S
K
S
G
Y
P
K
T
Site 38
S413
Q
N
R
M
L
S
K
S
G
Y
P
K
T
P
G
Site 39
Y415
R
M
L
S
K
S
G
Y
P
K
T
P
G
R
A
Site 40
T418
S
K
S
G
Y
P
K
T
P
G
R
A
G
T
E
Site 41
T424
K
T
P
G
R
A
G
T
E
A
L
P
D
G
L
Site 42
S432
E
A
L
P
D
G
L
S
V
E
D
I
L
N
L
Site 43
S444
L
N
L
L
G
M
E
S
A
A
N
Q
K
T
S
Site 44
S451
S
A
A
N
Q
K
T
S
Y
F
P
N
P
Y
N
Site 45
Y452
A
A
N
Q
K
T
S
Y
F
P
N
P
Y
N
Q
Site 46
Y457
T
S
Y
F
P
N
P
Y
N
Q
E
K
V
L
P
Site 47
Y468
K
V
L
P
R
L
P
Y
G
A
G
R
S
R
S
Site 48
S473
L
P
Y
G
A
G
R
S
R
S
N
Q
L
P
K
Site 49
S475
Y
G
A
G
R
S
R
S
N
Q
L
P
K
A
A
Site 50
Y494
V
E
N
R
Q
M
A
Y
E
N
L
N
D
K
D
Site 51
Y507
K
D
Q
E
L
G
E
Y
L
A
R
M
L
V
K
Site 52
S521
K
Y
P
E
I
I
N
S
N
Q
V
K
R
V
P
Site 53
S532
K
R
V
P
G
Q
G
S
S
E
D
D
L
Q
E
Site 54
S533
R
V
P
G
Q
G
S
S
E
D
D
L
Q
E
E
Site 55
S555
K
E
H
L
N
Q
G
S
S
Q
E
T
D
K
L
Site 56
S556
E
H
L
N
Q
G
S
S
Q
E
T
D
K
L
A
Site 57
T559
N
Q
G
S
S
Q
E
T
D
K
L
A
P
V
S
Site 58
S566
T
D
K
L
A
P
V
S
K
R
F
P
V
G
P
Site 59
T579
G
P
P
K
N
D
D
T
P
N
R
Q
Y
W
D
Site 60
Y584
D
D
T
P
N
R
Q
Y
W
D
E
D
L
L
M
Site 61
Y596
L
L
M
K
V
L
E
Y
L
N
Q
E
K
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation