PhosphoNET

           
Protein Info 
   
Short Name:  K5
Full Name:  Keratin, type II cytoskeletal 5
Alias:  58 kDa cytokeratin; CK 5; CK5; CK-5; Cytokeratin 5; Cytokeratin-5; EBS2; K2C5; Keratin 5; Keratin-5; KRT5; KRT5, keratin, type II cytoskeletal 5; KRT5A
Type:  Cytoskeletal protein
Mass (Da):  62378
Number AA:  590
UniProt ID:  P13647
International Prot ID:  IPI00009867
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0045095     Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0005200   PhosphoSite+ KinaseNET
Biological Process:  GO:0008544     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S5___MSRQSSVSFRSG
Site 2S6__MSRQSSVSFRSGG
Site 3S8MSRQSSVSFRSGGSR
Site 4S11QSSVSFRSGGSRSFS
Site 5S14VSFRSGGSRSFSTAS
Site 6S16FRSGGSRSFSTASAI
Site 7S18SGGSRSFSTASAITP
Site 8T19GGSRSFSTASAITPS
Site 9S21SRSFSTASAITPSVS
Site 10T24FSTASAITPSVSRTS
Site 11S26TASAITPSVSRTSFT
Site 12T30ITPSVSRTSFTSVSR
Site 13S31TPSVSRTSFTSVSRS
Site 14T33SVSRTSFTSVSRSGG
Site 15S34VSRTSFTSVSRSGGG
Site 16S36RTSFTSVSRSGGGGG
Site 17S38SFTSVSRSGGGGGGG
Site 18S50GGGFGRVSLAGACGV
Site 19Y60GACGVGGYGSRSLYN
Site 20S62CGVGGYGSRSLYNLG
Site 21S64VGGYGSRSLYNLGGS
Site 22Y66GYGSRSLYNLGGSKR
Site 23S71SLYNLGGSKRISIST
Site 24S75LGGSKRISISTSGGS
Site 25S77GSKRISISTSGGSFR
Site 26T78SKRISISTSGGSFRN
Site 27S79KRISISTSGGSFRNR
Site 28S82SISTSGGSFRNRFGA
Site 29S160LNLQIDPSIQRVRTE
Site 30T166PSIQRVRTEEREQIK
Site 31T174EEREQIKTLNNKFAS
Site 32S181TLNNKFASFIDKVRF
Site 33T210LQEQGTKTVRQNLEP
Site 34S232NLRRQLDSIVGERGR
Site 35S242GERGRLDSELRNMQD
Site 36Y258VEDFKNKYEDEINKR
Site 37T267DEINKRTTAENEFVM
Site 38Y283KKDVDAAYMNKVELE
Site 39T316AELSQMQTHVSDTSV
Site 40S319SQMQTHVSDTSVVLS
Site 41T321MQTHVSDTSVVLSMD
Site 42S322QTHVSDTSVVLSMDN
Site 43S326SDTSVVLSMDNNRNL
Site 44S337NRNLDLDSIIAEVKA
Site 45Y346IAEVKAQYEEIANRS
Site 46S353YEEIANRSRTEAESW
Site 47T355EIANRSRTEAESWYQ
Site 48S359RSRTEAESWYQTKYE
Site 49Y361RTEAESWYQTKYEEL
Site 50T363EAESWYQTKYEELQQ
Site 51Y365ESWYQTKYEELQQTA
Site 52T371KYEELQQTAGRHGDD
Site 53T382HGDDLRNTKHEISEM
Site 54Y453MARLLREYQELMNTK
Site 55Y470LDVEIATYRKLLEGE
Site 56S482EGEECRLSGEGVGPV
Site 57S499SVVTSSVSSGYGSGS
Site 58S500VVTSSVSSGYGSGSG
Site 59Y502TSSVSSGYGSGSGYG
Site 60S504SVSSGYGSGSGYGGG
Site 61S506SSGYGSGSGYGGGLG
Site 62Y508GYGSGSGYGGGLGGG
Site 63S528GGGLAGGSSGSYYSS
Site 64S529GGLAGGSSGSYYSSS
Site 65S531LAGGSSGSYYSSSSG
Site 66Y532AGGSSGSYYSSSSGG
Site 67Y533GGSSGSYYSSSSGGV
Site 68S534GSSGSYYSSSSGGVG
Site 69S535SSGSYYSSSSGGVGL
Site 70S536SGSYYSSSSGGVGLG
Site 71S537GSYYSSSSGGVGLGG
Site 72S554SVGGSGFSASSGRGL
Site 73S556GGSGFSASSGRGLGV
Site 74S557GSGFSASSGRGLGVG
Site 75S567GLGVGFGSGGGSSSS
Site 76S571GFGSGGGSSSSVKFV
Site 77S572FGSGGGSSSSVKFVS
Site 78S573GSGGGSSSSVKFVST
Site 79S574SGGGSSSSVKFVSTT
Site 80S579SSSVKFVSTTSSSRK
Site 81T580SSVKFVSTTSSSRKS
Site 82T581SVKFVSTTSSSRKSF
Site 83S582VKFVSTTSSSRKSFK
Site 84S583KFVSTTSSSRKSFKS
Site 85S584FVSTTSSSRKSFKS_
Site 86S587TTSSSRKSFKS____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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