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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDIA4
Full Name:
Protein disulfide-isomerase A4
Alias:
EC 5.3.4.1; ERP70; ERP72; Protein ERp-72
Type:
Endoplasmic reticulum lumen, Endoplasmic reticulum, Melanosome protein
Mass (Da):
72932
Number AA:
645
UniProt ID:
P13667
International Prot ID:
IPI00009904
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005788
GO:0016023
Uniprot
OncoNet
Molecular Function:
GO:0003756
GO:0003824
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0009306
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
A
E
G
P
D
E
D
S
S
N
R
E
N
A
I
Site 2
S32
E
G
P
D
E
D
S
S
N
R
E
N
A
I
E
Site 3
Y101
C
K
Q
F
A
P
E
Y
E
K
I
A
N
I
L
Site 4
S126
K
I
D
A
T
S
A
S
V
L
A
S
R
F
D
Site 5
Y137
S
R
F
D
V
S
G
Y
P
T
I
K
I
L
K
Site 6
T139
F
D
V
S
G
Y
P
T
I
K
I
L
K
K
G
Site 7
Y151
K
K
G
Q
A
V
D
Y
E
G
S
R
T
Q
E
Site 8
T156
V
D
Y
E
G
S
R
T
Q
E
E
I
V
A
K
Site 9
S168
V
A
K
V
R
E
V
S
Q
P
D
W
T
P
P
Site 10
T173
E
V
S
Q
P
D
W
T
P
P
P
E
V
T
L
Site 11
S224
E
K
A
A
K
E
L
S
K
R
S
P
P
I
P
Site 12
S227
A
K
E
L
S
K
R
S
P
P
I
P
L
A
K
Site 13
T238
P
L
A
K
V
D
A
T
A
E
T
D
L
A
K
Site 14
S250
L
A
K
R
F
D
V
S
G
Y
P
T
L
K
I
Site 15
Y252
K
R
F
D
V
S
G
Y
P
T
L
K
I
F
R
Site 16
T254
F
D
V
S
G
Y
P
T
L
K
I
F
R
K
G
Site 17
Y264
I
F
R
K
G
R
P
Y
D
Y
N
G
P
R
E
Site 18
Y266
R
K
G
R
P
Y
D
Y
N
G
P
R
E
K
Y
Site 19
Y273
Y
N
G
P
R
E
K
Y
G
I
V
D
Y
M
I
Site 20
Y278
E
K
Y
G
I
V
D
Y
M
I
E
Q
S
G
P
Site 21
S283
V
D
Y
M
I
E
Q
S
G
P
P
S
K
E
I
Site 22
S287
I
E
Q
S
G
P
P
S
K
E
I
L
T
L
K
Site 23
S316
I
G
V
F
K
G
E
S
D
P
A
Y
Q
Q
Y
Site 24
Y320
K
G
E
S
D
P
A
Y
Q
Q
Y
Q
D
A
A
Site 25
Y334
A
N
N
L
R
E
D
Y
K
F
H
H
T
F
S
Site 26
T339
E
D
Y
K
F
H
H
T
F
S
T
E
I
A
K
Site 27
S365
M
Q
P
E
K
F
Q
S
K
Y
E
P
R
S
H
Site 28
Y367
P
E
K
F
Q
S
K
Y
E
P
R
S
H
M
M
Site 29
S371
Q
S
K
Y
E
P
R
S
H
M
M
D
V
Q
G
Site 30
S379
H
M
M
D
V
Q
G
S
T
Q
D
S
A
I
K
Site 31
S383
V
Q
G
S
T
Q
D
S
A
I
K
D
F
V
L
Site 32
S403
L
V
G
H
R
K
V
S
N
D
A
K
R
Y
T
Site 33
Y409
V
S
N
D
A
K
R
Y
T
R
R
P
L
V
V
Site 34
T410
S
N
D
A
K
R
Y
T
R
R
P
L
V
V
V
Site 35
S424
V
Y
Y
S
V
D
F
S
F
D
Y
R
A
A
T
Site 36
Y427
S
V
D
F
S
F
D
Y
R
A
A
T
Q
F
W
Site 37
T431
S
F
D
Y
R
A
A
T
Q
F
W
R
S
K
V
Site 38
T449
A
K
D
F
P
E
Y
T
F
A
I
A
D
E
E
Site 39
Y458
A
I
A
D
E
E
D
Y
A
G
E
V
K
D
L
Site 40
S468
E
V
K
D
L
G
L
S
E
S
G
E
D
V
N
Site 41
S470
K
D
L
G
L
S
E
S
G
E
D
V
N
A
A
Site 42
S495
M
E
P
E
E
F
D
S
D
T
L
R
E
F
V
Site 43
T497
P
E
E
F
D
S
D
T
L
R
E
F
V
T
A
Site 44
S516
K
L
K
P
V
I
K
S
Q
P
V
P
K
N
N
Site 45
S537
V
V
G
K
T
F
D
S
I
V
M
D
P
K
K
Site 46
Y551
K
D
V
L
I
E
F
Y
A
P
W
C
G
H
C
Site 47
Y565
C
K
Q
L
E
P
V
Y
N
S
L
A
K
K
Y
Site 48
S567
Q
L
E
P
V
Y
N
S
L
A
K
K
Y
K
G
Site 49
T586
V
I
A
K
M
D
A
T
A
N
D
V
P
S
D
Site 50
S592
A
T
A
N
D
V
P
S
D
R
Y
K
V
E
G
Site 51
Y595
N
D
V
P
S
D
R
Y
K
V
E
G
F
P
T
Site 52
T602
Y
K
V
E
G
F
P
T
I
Y
F
A
P
S
G
Site 53
Y604
V
E
G
F
P
T
I
Y
F
A
P
S
G
D
K
Site 54
S628
D
R
D
L
E
H
L
S
K
F
I
E
E
H
A
Site 55
T636
K
F
I
E
E
H
A
T
K
L
S
R
T
K
E
Site 56
S639
E
E
H
A
T
K
L
S
R
T
K
E
E
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation