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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
P4HA1
Full Name:
Prolyl 4-hydroxylase subunit alpha-1
Alias:
4-PH alpha-1; P4HA
Type:
Uncharacterized protein
Mass (Da):
61049
Number AA:
534
UniProt ID:
P13674
International Prot ID:
IPI00009923
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0031418
GO:0005506
GO:0016702
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T40
H
T
E
K
D
L
V
T
S
L
K
D
Y
I
K
Site 2
S41
T
E
K
D
L
V
T
S
L
K
D
Y
I
K
A
Site 3
Y45
L
V
T
S
L
K
D
Y
I
K
A
E
E
D
K
Site 4
T67
A
E
K
L
D
R
L
T
S
T
A
T
K
D
P
Site 5
S68
E
K
L
D
R
L
T
S
T
A
T
K
D
P
E
Site 6
T69
K
L
D
R
L
T
S
T
A
T
K
D
P
E
G
Site 7
T71
D
R
L
T
S
T
A
T
K
D
P
E
G
F
V
Site 8
T93
K
L
M
K
R
L
N
T
E
W
S
E
L
E
N
Site 9
S96
K
R
L
N
T
E
W
S
E
L
E
N
L
V
L
Site 10
Y120
N
L
T
I
Q
R
Q
Y
F
P
N
D
E
D
Q
Site 11
T140
A
L
L
R
L
Q
D
T
Y
N
L
D
T
D
T
Site 12
Y141
L
L
R
L
Q
D
T
Y
N
L
D
T
D
T
I
Site 13
T145
Q
D
T
Y
N
L
D
T
D
T
I
S
K
G
N
Site 14
T147
T
Y
N
L
D
T
D
T
I
S
K
G
N
L
P
Site 15
S149
N
L
D
T
D
T
I
S
K
G
N
L
P
G
V
Site 16
S160
L
P
G
V
K
H
K
S
F
L
T
A
E
D
C
Site 17
Y180
V
A
Y
T
E
A
D
Y
Y
H
T
E
L
W
M
Site 18
Y181
A
Y
T
E
A
D
Y
Y
H
T
E
L
W
M
E
Site 19
S200
Q
L
D
E
G
E
I
S
T
I
D
K
V
S
V
Site 20
Y210
D
K
V
S
V
L
D
Y
L
S
Y
A
V
Y
Q
Site 21
Y213
S
V
L
D
Y
L
S
Y
A
V
Y
Q
Q
G
D
Site 22
Y216
D
Y
L
S
Y
A
V
Y
Q
Q
G
D
L
D
K
Site 23
Y247
R
A
N
G
N
L
K
Y
F
E
Y
I
M
A
K
Site 24
Y250
G
N
L
K
Y
F
E
Y
I
M
A
K
E
K
D
Site 25
S261
K
E
K
D
V
N
K
S
A
S
D
D
Q
S
D
Site 26
S263
K
D
V
N
K
S
A
S
D
D
Q
S
D
Q
K
Site 27
S267
K
S
A
S
D
D
Q
S
D
Q
K
T
T
P
K
Site 28
T271
D
D
Q
S
D
Q
K
T
T
P
K
K
K
G
V
Site 29
T272
D
Q
S
D
Q
K
T
T
P
K
K
K
G
V
A
Site 30
Y282
K
K
G
V
A
V
D
Y
L
P
E
R
Q
K
Y
Site 31
Y289
Y
L
P
E
R
Q
K
Y
E
M
L
C
R
G
E
Site 32
T301
R
G
E
G
I
K
M
T
P
R
R
Q
K
K
L
Site 33
T364
K
P
R
L
R
R
A
T
I
S
N
P
I
T
G
Site 34
S366
R
L
R
R
A
T
I
S
N
P
I
T
G
D
L
Site 35
T370
A
T
I
S
N
P
I
T
G
D
L
E
T
V
H
Site 36
T375
P
I
T
G
D
L
E
T
V
H
Y
R
I
S
K
Site 37
Y378
G
D
L
E
T
V
H
Y
R
I
S
K
S
A
W
Site 38
S381
E
T
V
H
Y
R
I
S
K
S
A
W
L
S
G
Site 39
S383
V
H
Y
R
I
S
K
S
A
W
L
S
G
Y
E
Site 40
S387
I
S
K
S
A
W
L
S
G
Y
E
N
P
V
V
Site 41
Y389
K
S
A
W
L
S
G
Y
E
N
P
V
V
S
R
Site 42
T405
N
M
R
I
Q
D
L
T
G
L
D
V
S
T
A
Site 43
Y420
E
E
L
Q
V
A
N
Y
G
V
G
G
Q
Y
E
Site 44
Y426
N
Y
G
V
G
G
Q
Y
E
P
H
F
D
F
A
Site 45
S474
V
F
P
E
V
G
A
S
V
W
P
K
K
G
T
Site 46
Y496
F
A
S
G
E
G
D
Y
S
T
R
H
A
A
C
Site 47
S497
A
S
G
E
G
D
Y
S
T
R
H
A
A
C
P
Site 48
T498
S
G
E
G
D
Y
S
T
R
H
A
A
C
P
V
Site 49
T529
Q
E
F
R
R
P
C
T
L
S
E
L
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation