KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
APEH
Full Name:
Acylamino-acid-releasing enzyme
Alias:
Aare; Acph; Acylamino-acid-releasing enzyme; Acylaminoacyl-peptidase; Aph; D3F15S2; D3S48E; DNF15S2; EC 3.4.19.1; N-acylaminoacyl-peptide hydrolase; Oph; Oxidized protein hydrolase
Type:
Protease; EC 3.4.19.1
Mass (Da):
81225
Number AA:
732
UniProt ID:
P13798
International Prot ID:
IPI00337741
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
R
Q
V
L
L
S
E
P
E
E
A
A
A
Site 2
S21
A
A
L
Y
R
G
L
S
R
Q
P
A
L
S
A
Site 3
S27
L
S
R
Q
P
A
L
S
A
A
C
L
G
P
E
Site 4
T51
R
T
V
H
T
E
W
T
Q
R
D
L
E
R
M
Site 5
Y67
N
I
R
F
C
R
Q
Y
L
V
F
H
D
G
D
Site 6
S85
F
A
G
P
A
G
N
S
V
E
T
R
G
E
L
Site 7
S94
E
T
R
G
E
L
L
S
R
E
S
P
S
G
T
Site 8
S97
G
E
L
L
S
R
E
S
P
S
G
T
M
K
A
Site 9
T101
S
R
E
S
P
S
G
T
M
K
A
V
L
R
K
Site 10
S132
E
K
N
R
K
L
K
S
F
N
L
S
A
L
E
Site 11
S136
K
L
K
S
F
N
L
S
A
L
E
K
H
G
P
Site 12
Y145
L
E
K
H
G
P
V
Y
E
D
D
C
F
G
C
Site 13
S158
G
C
L
S
W
S
H
S
E
T
H
L
L
Y
V
Site 14
T160
L
S
W
S
H
S
E
T
H
L
L
Y
V
A
E
Site 15
Y164
H
S
E
T
H
L
L
Y
V
A
E
K
K
R
P
Site 16
S175
K
K
R
P
K
A
E
S
F
F
Q
T
K
A
L
Site 17
T179
K
A
E
S
F
F
Q
T
K
A
L
D
V
S
A
Site 18
S185
Q
T
K
A
L
D
V
S
A
S
D
D
E
I
A
Site 19
S187
K
A
L
D
V
S
A
S
D
D
E
I
A
R
L
Site 20
Y209
K
G
D
Q
F
V
F
Y
E
D
W
G
E
N
M
Site 21
S235
D
V
E
S
G
N
I
S
V
L
E
G
V
P
E
Site 22
S245
E
G
V
P
E
N
V
S
P
G
Q
A
F
W
A
Site 23
T276
R
L
G
I
R
F
C
T
N
R
R
S
A
L
Y
Site 24
Y283
T
N
R
R
S
A
L
Y
Y
V
D
L
I
G
G
Site 25
Y284
N
R
R
S
A
L
Y
Y
V
D
L
I
G
G
K
Site 26
S296
G
G
K
C
E
L
L
S
D
D
S
L
A
V
S
Site 27
S299
C
E
L
L
S
D
D
S
L
A
V
S
S
P
R
Site 28
S303
S
D
D
S
L
A
V
S
S
P
R
L
S
P
D
Site 29
S304
D
D
S
L
A
V
S
S
P
R
L
S
P
D
Q
Site 30
S308
A
V
S
S
P
R
L
S
P
D
Q
C
R
I
V
Site 31
S373
L
G
C
W
S
A
D
S
Q
R
V
V
F
D
S
Site 32
S380
S
Q
R
V
V
F
D
S
A
Q
R
S
R
Q
D
Site 33
S384
V
F
D
S
A
Q
R
S
R
Q
D
L
F
A
V
Site 34
S440
L
K
V
G
F
L
P
S
A
G
K
E
Q
S
V
Site 35
S446
P
S
A
G
K
E
Q
S
V
L
W
V
S
L
E
Site 36
S451
E
Q
S
V
L
W
V
S
L
E
E
A
E
P
I
Site 37
Y479
P
E
Q
E
N
V
Q
Y
A
G
L
D
F
E
A
Site 38
S493
A
I
L
L
Q
P
G
S
P
P
D
K
T
Q
V
Site 39
T498
P
G
S
P
P
D
K
T
Q
V
P
M
V
V
M
Site 40
S540
L
L
V
N
Y
R
G
S
T
G
F
G
Q
D
S
Site 41
T541
L
V
N
Y
R
G
S
T
G
F
G
Q
D
S
I
Site 42
S547
S
T
G
F
G
Q
D
S
I
L
S
L
P
G
N
Site 43
S550
F
G
Q
D
S
I
L
S
L
P
G
N
V
G
H
Site 44
S579
Q
E
E
H
F
D
A
S
H
V
A
L
M
G
G
Site 45
Y600
S
C
H
L
I
G
Q
Y
P
E
T
Y
R
A
C
Site 46
T603
L
I
G
Q
Y
P
E
T
Y
R
A
C
V
A
R
Site 47
S639
E
A
G
F
P
F
S
S
D
C
L
P
D
L
S
Site 48
S655
W
A
E
M
L
D
K
S
P
I
R
Y
I
P
Q
Site 49
Y659
L
D
K
S
P
I
R
Y
I
P
Q
V
K
T
P
Site 50
Y686
P
F
K
Q
G
M
E
Y
Y
R
A
L
K
T
R
Site 51
T692
E
Y
Y
R
A
L
K
T
R
N
V
P
V
R
L
Site 52
S705
R
L
L
L
Y
P
K
S
T
H
A
L
S
E
V
Site 53
S710
P
K
S
T
H
A
L
S
E
V
E
V
E
S
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation