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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TFIIF
Full Name:
General transcription factor IIF subunit 2
Alias:
BTF4; general transcription factor IIF, polypeptide 1 (74kD subunit); general transcription factor IIF, polypeptide 2 (30kD subunit); general transcription factor IIF, polypeptide 2, 30kDa; GTF2F2; RAP30; T2FB; TF2F2
Type:
EC 3.6.1.-; Transcription initiation complex; Helicase
Mass (Da):
28380
Number AA:
249
UniProt ID:
P13984
International Prot ID:
IPI00329767
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005674
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0000398
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
E
R
G
E
L
D
L
T
G
A
K
Q
N
T
G
Site 2
Y26
W
L
V
K
V
P
K
Y
L
S
Q
Q
W
A
K
Site 3
S28
V
K
V
P
K
Y
L
S
Q
Q
W
A
K
A
S
Site 4
S35
S
Q
Q
W
A
K
A
S
G
R
G
E
V
G
K
Site 5
T48
G
K
L
R
I
A
K
T
Q
G
R
T
E
V
S
Site 6
S55
T
Q
G
R
T
E
V
S
F
T
L
N
E
D
L
Site 7
T57
G
R
T
E
V
S
F
T
L
N
E
D
L
A
N
Site 8
S74
D
I
G
G
K
P
A
S
V
S
A
P
R
E
H
Site 9
S76
G
G
K
P
A
S
V
S
A
P
R
E
H
P
F
Site 10
S87
E
H
P
F
V
L
Q
S
V
G
G
Q
T
L
T
Site 11
T94
S
V
G
G
Q
T
L
T
V
F
T
E
S
S
S
Site 12
T97
G
Q
T
L
T
V
F
T
E
S
S
S
D
K
L
Site 13
S99
T
L
T
V
F
T
E
S
S
S
D
K
L
S
L
Site 14
S100
L
T
V
F
T
E
S
S
S
D
K
L
S
L
E
Site 15
S101
T
V
F
T
E
S
S
S
D
K
L
S
L
E
G
Site 16
S105
E
S
S
S
D
K
L
S
L
E
G
I
V
V
Q
Site 17
Y124
R
P
A
A
S
E
N
Y
M
R
L
K
R
L
Q
Site 18
S135
K
R
L
Q
I
E
E
S
S
K
P
V
R
L
S
Site 19
S142
S
S
K
P
V
R
L
S
Q
Q
L
D
K
V
V
Site 20
Y153
D
K
V
V
T
T
N
Y
K
P
V
A
N
H
Q
Site 21
Y165
N
H
Q
Y
N
I
E
Y
E
R
K
K
K
E
D
Site 22
Y196
S
A
F
E
K
H
Q
Y
Y
N
L
K
D
L
V
Site 23
Y197
A
F
E
K
H
Q
Y
Y
N
L
K
D
L
V
D
Site 24
T232
V
K
G
I
H
K
N
T
W
E
L
K
P
E
Y
Site 25
Y239
T
W
E
L
K
P
E
Y
R
H
Y
Q
G
E
E
Site 26
Y242
L
K
P
E
Y
R
H
Y
Q
G
E
E
K
S
D
Site 27
S248
H
Y
Q
G
E
E
K
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation