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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRF1
Full Name:
Perforin-1
Alias:
Cytolysin;Lymphocyte pore-forming protein
Type:
Mass (Da):
61377
Number AA:
555
UniProt ID:
P14222
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
P
V
P
A
P
C
H
T
A
A
R
S
E
C
K
Site 2
S29
P
C
H
T
A
A
R
S
E
C
K
R
S
H
K
Site 3
S34
A
R
S
E
C
K
R
S
H
K
F
V
P
G
A
Site 4
T51
A
G
E
G
V
D
V
T
S
L
R
R
S
G
S
Site 5
S52
G
E
G
V
D
V
T
S
L
R
R
S
G
S
F
Site 6
S56
D
V
T
S
L
R
R
S
G
S
F
P
V
D
T
Site 7
S58
T
S
L
R
R
S
G
S
F
P
V
D
T
Q
R
Site 8
T63
S
G
S
F
P
V
D
T
Q
R
F
L
R
P
D
Site 9
T72
R
F
L
R
P
D
G
T
C
T
L
C
E
N
A
Site 10
T74
L
R
P
D
G
T
C
T
L
C
E
N
A
L
Q
Site 11
T93
Q
R
L
P
L
A
L
T
N
W
R
A
Q
G
S
Site 12
T107
S
G
C
Q
R
H
V
T
R
A
K
V
S
S
T
Site 13
S113
V
T
R
A
K
V
S
S
T
E
A
V
A
R
D
Site 14
S124
V
A
R
D
A
A
R
S
I
R
N
D
W
K
V
Site 15
T136
W
K
V
G
L
D
V
T
P
K
P
T
S
N
V
Site 16
S141
D
V
T
P
K
P
T
S
N
V
H
V
S
V
A
Site 17
S146
P
T
S
N
V
H
V
S
V
A
G
S
H
S
Q
Site 18
Y167
Q
K
T
H
Q
D
Q
Y
S
F
S
T
D
T
V
Site 19
S168
K
T
H
Q
D
Q
Y
S
F
S
T
D
T
V
E
Site 20
T173
Q
Y
S
F
S
T
D
T
V
E
C
R
F
Y
S
Site 21
Y179
D
T
V
E
C
R
F
Y
S
F
H
V
V
H
T
Site 22
T186
Y
S
F
H
V
V
H
T
P
P
L
H
P
D
F
Site 23
T208
P
H
H
F
N
A
S
T
Q
P
A
Y
L
R
L
Site 24
Y212
N
A
S
T
Q
P
A
Y
L
R
L
I
S
N
Y
Site 25
Y219
Y
L
R
L
I
S
N
Y
G
T
H
F
I
R
A
Site 26
T221
R
L
I
S
N
Y
G
T
H
F
I
R
A
V
E
Site 27
T259
N
E
V
E
D
C
L
T
V
E
A
Q
V
N
I
Site 28
S291
K
K
H
K
M
T
A
S
F
H
Q
T
Y
R
E
Site 29
T295
M
T
A
S
F
H
Q
T
Y
R
E
R
H
S
E
Site 30
S301
Q
T
Y
R
E
R
H
S
E
V
V
G
G
H
H
Site 31
S331
Q
Y
S
A
W
V
N
S
L
P
G
S
P
G
L
Site 32
S335
W
V
N
S
L
P
G
S
P
G
L
V
D
Y
T
Site 33
S352
P
L
H
V
L
L
D
S
Q
D
P
R
R
E
A
Site 34
S365
E
A
L
R
R
A
L
S
Q
Y
L
T
D
R
A
Site 35
Y367
L
R
R
A
L
S
Q
Y
L
T
D
R
A
R
W
Site 36
T369
R
A
L
S
Q
Y
L
T
D
R
A
R
W
R
D
Site 37
S378
R
A
R
W
R
D
C
S
R
P
C
P
P
G
R
Site 38
S388
C
P
P
G
R
Q
K
S
P
R
D
P
C
Q
C
Site 39
S451
G
G
Q
E
L
R
T
S
T
V
W
D
N
N
N
Site 40
T452
G
Q
E
L
R
T
S
T
V
W
D
N
N
N
P
Site 41
S487
L
Q
V
W
D
Q
D
S
G
R
D
D
D
L
L
Site 42
S503
T
C
D
Q
A
P
K
S
G
S
H
E
V
R
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation